Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-23T22:22:18.281Z Has data issue: false hasContentIssue false
  • English
  • Français

Familial liability to psychosis is a risk factor for multimorbidity in people with psychotic disorders and their unaffected siblings

Published online by Cambridge University Press:  23 March 2020

M.A. Islam ,
M.F.H. Khan ,
P.J. Quee ,
H. Snieder ,
E.R. van den Heuvel ,
R. Bruggeman ,
B.Z. Alizadeh ,
A.A. Bartels-Velthuis ,
N.J. van Beveren  and
W. Cahn
...Show all authors
M.A. Islam*
Affiliation:
University Center for Psychiatry, Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Department of Statistics, Shahjalal University of Science and Technology, Sylhet3114, Bangladesh
M.F.H. Khan
Affiliation:
University Center for Psychiatry, Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
P.J. Quee
Affiliation:
University Psychiatric Centre (UPC), KU Leuven, campus Kortenberg, Leuven, Belgium
H. Snieder
Affiliation:
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
E.R. van den Heuvel
Affiliation:
Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, The Netherlands
R. Bruggeman
Affiliation:
University Center for Psychiatry, Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
B.Z. Alizadeh
Affiliation:
University Center for Psychiatry, Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
A.A. Bartels-Velthuis
Affiliation:
University of Groningen, University Medical Center Groningen, University Center for Psychiatry, Groningen, The Netherlands
N.J. van Beveren
Affiliation:
Antes Center for Mental Health Care, Rotterdam, The Netherlands Erasmus MC, Department of Psychiatry, Rotterdam, The Netherlands Erasmus MC, Department of Neuroscience, Rotterdam, The Netherlands
W. Cahn
Affiliation:
University Medical Center Utrecht, Department of Psychiatry, Brain Centre Rudolf Magnus, Utrecht, The Netherlands
L. de Haan
Affiliation:
Academic Medical Center, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands
P. Delespaul
Affiliation:
Maastricht University Medical Center, Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht, The Netherlands
C.J. Meijer
Affiliation:
Academic Medical Center, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands
I. Myin-Germeys
Affiliation:
KU Leuven, Department of Neuroscience, Research Group Psychiatry, Center for Contextual Psychiatry, Leuven, Belgium
R.S. Kahn
Affiliation:
University Medical Center Utrecht, Department of Psychiatry, Brain Centre Rudolf Magnus, Utrecht, The Netherlands
F. Schirmbeck
Affiliation:
Academic Medical Center, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands
C.J.P. Simons
Affiliation:
Maastricht University Medical Center, Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht, The Netherlands GGzE, Institute for Mental Health Care Eindhoven and De Kempen, Eindhoven, The Netherlands
N.E. van Haren
Affiliation:
University Medical Center Utrecht, Department of Psychiatry, Brain Centre Rudolf Magnus, Utrecht, The Netherlands
J. van Os
Affiliation:
Maastricht University Medical Center, Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht, The Netherlands King's College London, King's Health Partners, Department of Psychosis Studies, Institute of Psychiatry, London, United Kingdom
R. van Winkel
Affiliation:
Maastricht University Medical Center, Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht, The Netherlands KU Leuven, Department of Neuroscience, Research Group Psychiatry, Center for Contextual Psychiatry, Leuven, Belgium
GROUP Investigators
Affiliation:
University of Groningen, University Medical Center Groningen, University Center for Psychiatry, Groningen, The Netherlands
*
*Corresponding author. University Center for Psychiatry, Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Hanzeplein 1 (9713 GZ), PO Box 30.001 (CC 72), 9700 RB, Groningen, The Netherlands. Fax: +31 50 36 19722. E-mail address:[email protected], [email protected] (M.A. Islam).
Get access

Abstract

Background:

Multimorbidity may impose an overwhelming burden on patients with psychosis and is affected by gender and age. Our aim is to study the independent role of familial liability to psychosis as a risk factor for multimorbidity.

Methods:

We performed the study within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) project. Overall, we compared 1024 psychotic patients, 994 unaffected siblings and 566 controls on the prevalence of 125 lifetime diseases, and 19 self-reported somatic complaints. Multimorbidity was defined as the presence of two or more complaints/diseases in the same individual. Generalized linear mixed model (GLMM) were used to investigate the effects of gender, age (adolescent, young, older) and familial liability (patients, siblings, controls) and their interactions on multimorbidity.

Results:

Familial liability had a significant effect on multimorbidity of either complaints or diseases. Patients had a higher prevalence of multimorbidity of complaints compared to siblings (OR 2.20, 95% CI 1.79–2.69, P < 0.001) and to controls (3.05, 2.35–3.96, P < 0.001). In physical health multimorbidity, patients (OR 1.36, 95% CI 1.05–1.75, P = 0.018), but not siblings, had significantly higher prevalence than controls. Similar finding were observed for multimorbidity of lifetime diseases, including psychiatric diseases. Significant results were observed for complaints and disease multimorbidity across gender and age groups.

Conclusion:

Multimorbidity is a common burden, significantly more prevalent in patients and their unaffected siblings. Familial liability to psychosis showed an independent effect on multimorbidity; gender and age are also important factors determining multimorbidity.

Keywords

Familial liabilityMultimorbidityPhysical healthPsychosisSchizophrenia
Type
Original article
Information
European Psychiatry , Volume 45 , September 2017 , pp. 81 - 89
Copyright
Copyright © European Psychiatric Association 2017

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Laursen, TMLife expectancy among persons with schizophrenia or bipolar affective disorder. Schizophr Res 2011;131:101–104.CrossRefGoogle ScholarPubMed
Korver, NQuee, PJBoos, HBMSimons, CJPde Haan, LInvestigators, GGenetic Risk and Outcome of Psychosis (GROUP), a multi-site longitudinal cohort study focused on gene-environment interaction: objectives, sample characteristics, recruitment and assessment methods. International Journal of Methods in Psychiatric Research 2012;21:205–221.CrossRefGoogle ScholarPubMed
Walker, ERMcGee, REDruss, BGMortality in mental disorders and global disease burden implications: a systematic review and meta-analysis. JAMA Psychiatry 2015;72:334–341.CrossRefGoogle ScholarPubMed
Lawrence, DHancock, KJKisely, SThe gap in life expectancy from preventable physical illness in psychiatric patients in Western Australia: retrospective analysis of population based registers. BMJ 2013;346.CrossRefGoogle Scholar
De Hert, MCorrell, CUBobes, JCetkovich-Bakmas, MCohen, DAsai, I, et al.Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care. World Psychiatry 2011;10:52–77.CrossRefGoogle ScholarPubMed
Bruins, JPijnenborg, MGBartels-Velthuis, AAVisser, Evan den Heuvel, ERBruggeman, R, et al.Cannabis use in people with severe mental illness: the association with physical and mental health – a cohort study. A pharmacotherapy monitoring and outcome survey study. J Psychopharmacol 2016;30:354–362.CrossRefGoogle ScholarPubMed
Vancampfort, DStubbs, BMitchell, AJDe Hert, MWampers, MWard, PB, et al.Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis. World Psychiatry 2015;14:339–347.CrossRefGoogle ScholarPubMed
Bushe, CHolt, RPrevalence of diabetes and impaired glucose tolerance in patients with schizophrenia. Br J Psychiatry Suppl 2004;47:S67–S71.CrossRefGoogle ScholarPubMed
van Winkel, RDe Hert, MVan Eyck, DHanssens, LWampers, MScheen, A, et al.Screening for diabetes and other metabolic abnormalities in patients with schizophrenia and schizoaffective disorder: evaluation of incidence and screening methods. J Clin Psychiatry 2006;67:1493–1500.CrossRefGoogle ScholarPubMed
Vancampfort, DCorrell, CUGalling, BProbst, MDe Hert, MWard, PB, et al.Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta-analysis. World Psychiatry 2016;15:166–174.CrossRefGoogle ScholarPubMed
Bresee, LCMajumdar, SRPatten, SBJohnson, JAPrevalence of cardiovascular risk factors and disease in people with schizophrenia: a population-based study. Schizophr Res 2010;117:75–82.CrossRefGoogle ScholarPubMed
Hennekens, CHHennekens, ARHollar, DCasey, DESchizophrenia and increased risks of cardiovascular disease. Am Heart J 2005;150:1115–1121.CrossRefGoogle Scholar
Hoang, UGoldacre, MJStewart, RAvoidable mortality in people with schizophrenia or bipolar disorder in England. Acta Psychiatr Scand 2013;127:195–201.CrossRefGoogle ScholarPubMed
Smith, DJLangan, JMcLean, GGuthrie, BMercer, SWSchizophrenia is associated with excess multiple physical-health comorbidities but low levels of recorded cardiovascular disease in primary care: cross-sectional study. BMJ Open 2013;3. http://dx.doi.org/10.1136/bmjopen-2013-002808.CrossRefGoogle Scholar
Iacovides, ASiamouli, MComorbid mental and somatic disorders: an epidemiological perspective. Curr Opin Psychiatry 2008;21:417–421.CrossRefGoogle Scholar
Barnett, KMercer, SWNorbury, MWatt, GWyke, SGuthrie, BEpidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. The Lancet 2012;380:37–43.CrossRefGoogle ScholarPubMed
Payne, RAAbel, GAGuthrie, BMercer, SWThe effect of physical multimorbidity, mental health conditions and socioeconomic deprivation on unplanned admissions to hospital: a retrospective cohort study. CMAJ: Canadian Medical Association Journal 2013;185:E221–E228.CrossRefGoogle Scholar
Qin, PHawton, KMortensen, PBWebb, RCombined effects of physical illness and comorbid psychiatric disorder on risk of suicide in a national population study. The British Journal of Psychiatry 2014;204:430–435.CrossRefGoogle Scholar
Reilly, SOlier, IPlanner, CDoran, TReeves, DAshcroft, DM, et al.Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK. BMJ Open 2015;5.CrossRefGoogle Scholar
Batstra, LBos, EHNeeleman, JQuantifying psychiatric comorbidity – lessions from chronic disease epidemiology. Soc Psychiatry Psychiatr Epidemiol 2002;37:105–111.CrossRefGoogle ScholarPubMed
Feinstein, ARThe pre-therapeutic classification of co-morbidity in chronic disease. J Chronic Dis 1970;23:455–468.CrossRefGoogle ScholarPubMed
Tomasdottir, MOGetz, LSigurdsson, JAPetursson, HKirkengen, ALKrokstad, S, et al.Co- and multi-morbidity patterns in an unselected Norwegian population: cross-sectional analysis based on the HUNT Study and theoretical reflections concerning basic medical models. European Journal for Person Centered Healthcare 2013;2:335–345.CrossRefGoogle Scholar
Schafer, IHansen, HSchon, GHofels, SAltiner, ADahlhaus, A, et al.The influence of age, gender and socio-economic status on multimorbidity patterns in primary care. First results from the multicare cohort study. BMC Health Serv Res 2012;12 [13–89,89–6963].CrossRefGoogle Scholar
Taylor, AWPrice, KGill, TKAdams, RPilkington, RCarrangis, N, et al.Multimorbidity – not just an older person's issue. Results from an Australian biomedical study. BMC Public Health. 2010;10 [11–718,718–2458].CrossRefGoogle Scholar
Lawrence, DKisely, SInequalities in healthcare provision for people with severe mental illness. J Psychopharmacol 2010;24:61–68.CrossRefGoogle ScholarPubMed
Agborsangaya, CBLau, DLahtinen, MCooke, TJohnson, JAMultimorbidity prevalence and patterns across socioeconomic determinants: a cross-sectional survey. BMC Public Health 2012;12:201.CrossRefGoogle Scholar
Britt, HCHarrison, CMMiller, GCKnox, SAPrevalence and patterns of multimorbidity in Australia. Med J Aust 2008;189:72–77.CrossRefGoogle Scholar
Fuchs, JBusch, MLange, CScheidt-Nave, CPrevalence and patterns of morbidity among adults in Germany. Results of the German telephone health interview survey German Health Update (GEDA) 2009. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012;55:576–586.CrossRefGoogle ScholarPubMed
Rizza, AKaplan, VSenn, ORosemann, TBhend, HTandjung, R, et al.Age- and gender-related prevalence of multimorbidity in primary care: the Swiss FIRE project. BMC Fam Pract 2012;13:113–2296.CrossRefGoogle ScholarPubMed
van den Akker, MBuntinx, FMetsemakers, JFRoos, SKnottnerus, JAMultimorbidity in general practice: prevalence, incidence, and determinants of co-occurring chronic and recurrent diseases. J Clin Epidemiol 1998;51:367–375.CrossRefGoogle ScholarPubMed
van Oostrom, SHPicavet, HSvan Gelder, BMLemmens, LCHoeymans, Nvan Dijk, CE, et al.Multimorbidity and comorbidity in the Dutch population – data from general practices. BMC Public Health 2012;12 [13–715,715–2458].CrossRefGoogle Scholar
McGrath, JSaha, SWelham, JEl Saadi, OMacCauley, CChant, DA systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology. BMC Medicine 2004;2:13.CrossRefGoogle ScholarPubMed
Batki, SLMeszaros, ZSStrutynski, KDimmock, JALeontieva, LPloutz-Snyder, R, et al.Medical comorbidity in patients with schizophrenia and alcohol dependence. Schizophr Res 2009;107:139–146.CrossRefGoogle ScholarPubMed
Manuel, CMRao, PPRebello, PSafeekh, ATMathai, PJMedical comorbidity in in-patients with psychiatric disorder. Muller Journal of Medical Science and Research 2013;4:12–17.Google Scholar
Häfner, HGender differences in schizophrenia. Psychoneuroendocrinology 2003;28(Suppl. 2):17–54.CrossRefGoogle Scholar
Abel, KMDrake, RGoldstein, JMSex differences in schizophrenia. International Review of Psychiatry 2010;22:417–428.CrossRefGoogle Scholar
Agur, KMcLean, GHunt, KGuthrie, BMercer, SWHow does sex influence multimorbidity? Secondary analysis of a large nationally representative dataset. International Journal of Environmental Research and Public Health 2016;13:391.CrossRefGoogle ScholarPubMed
Stubbs, BKoyanagi, AVeronese, NVancampfort, DSolmi, MGaughran, F, et al.Physical multimorbidity and psychosis: comprehensive cross sectional analysis including 242,952 people across 48 low- and middle-income countries. BMC Med 2016;14:189.CrossRefGoogle ScholarPubMed
Marengoni, AAngleman, SMelis, RMangialasche, FKarp, AGarmen, A, et al.Aging with multimorbidity: a systematic review of the literature. Ageing Res Rev 2011;10:430–439.CrossRefGoogle ScholarPubMed
Chen, LSRice, TKThompson, PABarch, DMCsernansky, JGFamilial aggregation of clinical and neurocognitive features in sibling pairs with and without schizophrenia. Schizophr Res 2009;111:159–166.CrossRefGoogle ScholarPubMed
Genetic Risk Outcome in Psychosis (GROUP) Investigators. Evidence that familial liability for psychosis is expressed as differential sensitivity to cannabis: an analysis of patient-sibling and sibling-control pairs. Arch Gen Psychiatry 2011;68:138–147.CrossRefGoogle Scholar
Gejman, PVSanders, ARKendler, KSGenetics of schizophrenia: new findings and challenges. Annu Rev Genom Hum Genet 2011;12:121–144.CrossRefGoogle ScholarPubMed
Gottesman, IIGould, TDThe endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003;160:636–645.CrossRefGoogle ScholarPubMed
Verhage, FIntelligentie en leeftijd: Onderzoek bij Nederlanders van twaalf tot zevenenzeventig jaar Assen: Van Gorcum; 1964Google Scholar
Wechsler, DCoalson, DLRaiford, SEWechsler Adult Intelligence Scale: technical and interpretive manual, Fourth ed., San Antonio, TX: Pearson; 2008.Google Scholar
Vos, HMBor, HHRangelrooij-Minkels, MJSchellevis, FGLagro-Janssen, ALMultimorbidity in older women: the negative impact of specific combinations of chronic conditions on self-rated health. Eur J Gen Pract 2013;19:117–122.CrossRefGoogle ScholarPubMed
Lampe, FCWalker, MLennon, LTWhincup, PHEbrahim, SValidity of a self-reported history of doctor-diagnosed angina. J Clin Epidemiol 1999;52:73–81.CrossRefGoogle ScholarPubMed
Molenberghs, GVerbeke, GModels for discrete longitudinal data New York: Springer-Verlag; 2006Google Scholar
den Boeft, MTwisk, JWRTerluin, BPenninx, B.W.J.H.van Marwijk, Harm, WJ, et al.The association between medically unexplained physical symptoms and health care use over two years and the influence of depressive and anxiety disorders and personality traits: a longitudinal study. BMC Health Services Research 2016;16:1–9.CrossRefGoogle Scholar
Stubbs, BMitchell, AJDe Hert, MCorrell, CUSoundy, AStroobants, M, et al.The prevalence and moderators of clinical pain in people with schizophrenia: a systematic review and large-scale meta-analysis. Schizophr Res 2014;160:1–8.CrossRefGoogle ScholarPubMed
Keshavan, MSTandon, RBoutros, NNNasrallah, HASchizophrenia, “just the facts": what we know in 2008. Part 3: neurobiology. Schizophr Res 2008;106:89–107.CrossRefGoogle ScholarPubMed
Seidel, SAigner, MOssege, MPernicka, EWildner, BSycha, TAntipsychotics for acute and chronic pain in adults. Cochrane Database Syst Rev 2013;8:CD004844.Google Scholar
Stubbs, BThompson, TAcaster, SVancampfort, DGaughran, FCorrell, CUDecreased pain sensitivity among people with schizophrenia: a meta-analysis of experimental pain induction studies. Pain 2015;156:2121–2131.CrossRefGoogle ScholarPubMed
Jarcho, JMMayer, EAJiang, ZKFeier, NALondon, EDPain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction. Pain 2012;153:744–754.CrossRefGoogle ScholarPubMed
Willadsen, TGBebe, AKoster-Rasmussen, RJarbol, DEGuassora, ADWaldorff, FB, et al.The role of diseases, risk factors and symptoms in the definition of multimorbidity – a systematic review. Scand J Prim Health Care 2016;34:112–121.CrossRefGoogle ScholarPubMed
Fortin, MBravo, GHudon, CVanasse, ALapointe, LPrevalence of multimorbidity among adults seen in family practice. Ann Fam Med 2005;3:223–228.CrossRefGoogle ScholarPubMed
Jacobi, FWittchen, HUHolting, CHofler, MPfister, HMuller, N, et al.Prevalence, co-morbidity and correlates of mental disorders in the general population: results from the German Health Interview and Examination Survey (GHS). Psychol Med 2004;34:597–611.CrossRefGoogle Scholar
Fortin, MStewart, MPoitras, MEAlmirall, JMaddocks, HA systematic review of prevalence studies on multimorbidity: toward a more uniform methodology. Ann Fam Med 2012;10:142–151.CrossRefGoogle Scholar
Schneider, FKaplan, VRodak, RBattegay, EHolzer, BPrevalence of multimorbidity in medical inpatients. Swiss Med Wkly 2012;142:w13533.Google ScholarPubMed
O’Kelly, SSmith, SMLane, STeljeur, CO’Dowd, TChronic respiratory disease and multimorbidity: prevalence and impact in a general practice setting. Respir Med 2011;105:236–242.CrossRefGoogle Scholar
Crump, CWinkleby, MASundquist, KSundquist, JComorbidities and mortality in persons with schizophrenia: a Swedish national cohort study. Am J Psychiatry 2013;170:324–333.CrossRefGoogle ScholarPubMed
Foguet-Boreu, QViolan, CRoso-Llorach, ARodriguez-Blanco, TPons-Vigues, MMunoz-Perez, MA, et al.Impact of multimorbidity: acute morbidity, area of residency and use of health services across the life span in a region of south Europe. BMC Fam Pract 2014;15 [16–55,55–2296].CrossRefGoogle Scholar
Ha, NTLe, NHKhanal, VMoorin, RMultimorbidity and its social determinants among older people in southern provinces, Vietnam. Int J Equity Health 2015;14 [50–015–0177–8].CrossRefGoogle Scholar
Hocaoglu, CEating disorders with comorbidity anxiety disorders. In: Jauregui-Lobera, I, editors. Eating disorders –a paradigm of the biopsychosocial model of illness Rijeka: InTech; 2017 [pp. Ch. 06].Google Scholar
Nuyen, JSchellevis, FGSatariano, WASpreeuwenberg, PMBirkner, MDvan den Bos, GA, et al.Comorbidity was associated with neurologic and psychiatric diseases: a general practice-based controlled study. J Clin Epidemiol 2006;59:1274–1284.CrossRefGoogle ScholarPubMed
Oreski, IJakovljevic, MAukst-Margetic, BOrlic, ZCVuksan-Cusa, BComorbidity and multimorbidity in patients with schizophrenia and bipolar disorder: similarities and differencies. Psychiatr Danub 2012;24:80–85.Google ScholarPubMed
Supplementary material: File

Islam et al. supplementary material

Islam et al. supplementary material
Download Islam et al. supplementary material(File)
File 106.6 KB
Submit a response

Comments

No Comments have been published for this article.