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Factors associated with response after deep transcranial magnetic stimulation in a real-world clinical setting: Results from the first 40 cases of treatment-resistant depression

Published online by Cambridge University Press:  23 March 2020

K. Feffer ,
K.A.B. Lapidus ,
Y. Braw ,
Y. Bloch ,
S. Kron ,
R. Netzer  and
U. Nitzan
K. Feffer
Affiliation:
Shalvata Mental Health Center, Hod-Hasharon, Sackler School of Medicine, Tel-Aviv University, P.O.B 94, Tel-Aviv, Israel
K.A.B. Lapidus
Affiliation:
Northwell Health Department of Psychiatry, Lenox Hill Hospital, New York, NY, USA
Y. Braw
Affiliation:
Department of Behavioral Sciences, Ariel University, Ariel, Israel
Y. Bloch
Affiliation:
Shalvata Mental Health Center, Hod-Hasharon, Sackler School of Medicine, Tel-Aviv University, P.O.B 94, Tel-Aviv, Israel
S. Kron
Affiliation:
Shalvata Mental Health Center, Hod-Hasharon, Sackler School of Medicine, Tel-Aviv University, P.O.B 94, Tel-Aviv, Israel
R. Netzer
Affiliation:
Shalvata Mental Health Center, Hod-Hasharon, Tel-Aviv, Israel
U. Nitzan*
Affiliation:
Shalvata Mental Health Center, Hod-Hasharon, Sackler School of Medicine, Tel-Aviv University, P.O.B 94, Tel-Aviv, Israel
*
* Corresponding author. Fax: +972 3 5496872. E-mail address:[email protected] (U. Nitzan).
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Abstract

Background:

Deep transcranial magnetic stimulation (dTMS) has been sanctioned by the United States Food and Drug Administration for treatment-resistant depression. In a retrospective cohort study, we evaluated response and effectiveness of dTMS in real-world practice, as an add-on treatment for resistant depression.

Methods:

Forty adult outpatients suffering from depression, all taking psychiatric medications, underwent 20 dTMS treatments over a 4–6 week period. At baseline (T0), visit 10 (T1), and visit 20 (T2), the Clinical Global Impression-Severity (CGI-S) scale was administered, and the Clinical Global Impression Improvement (CGI-I) scale was completed at T1 and T2; the Hamilton Depression Rating Scale (HDRS-21) was administrated at T0 and T2 only. The patients also completed the Quick Inventory of Depressive Symptoms–Self-Report (QIDS-SR) at T0, T1, and T2.

Results:

Depressive symptoms (HDRS-21 total score) decreased significantly following treatment. The HDRS total score decreased from an average of 21.22 (± 6.09) at T0, to 13.95 (± 7.24) at T2. Correspondingly, at T2, 32.5% were responders to the treatment and 20% were in remission, based on the HDRS-21. Treatment was well tolerated, with a discontinuation rate of 7.5%. While depressive symptoms at baseline did not predict remission/response at T2, higher HDRS scores at T0 were associated with a larger decrease in depressive symptoms during the study.

Conclusions:

Significant antidepressant effects were seen following 20 dTMS treatments, given as augmentation to ongoing medications in treatment-resistant depression. The findings suggest that among patients with TRD, the severity of the depressive episode (and not necessarily the number of failed antidepressant medication trials) is associated with a positive therapeutic effect of dTMS. Hence, the initial severity of the depressive episode may guide clinicians in referring patients for dTMS.

Keywords

Deep transcranial magnetic stimulationTreatment-resistant depressionBipolar disorderAugmentation
Type
Original article
Information
European Psychiatry , Volume 44 , July 2017 , pp. 61 - 67
Copyright
Copyright © European Psychiatric Association 2017

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