Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-20T13:22:44.981Z Has data issue: false hasContentIssue false
  • English
  • Français

Exposure to tobacco smoke in utero or during early childhood and risk of hypomania: Prospective birth cohort study

Published online by Cambridge University Press:  23 March 2020

D.F. Mackay ,
J.J. Anderson ,
J.P. Pell ,
S. Zammit  and
D.J. Smith
D.F. Mackay*
Affiliation:
Institute of health & wellbeing, university of Glasgow 1, Lilybank Gardens, G12 8RZGlasgow, Scotland, United Kingdom
J.J. Anderson
Affiliation:
Institute of health & wellbeing, university of Glasgow 1, Lilybank Gardens, G12 8RZGlasgow, Scotland, United Kingdom
J.P. Pell
Affiliation:
Institute of health & wellbeing, university of Glasgow 1, Lilybank Gardens, G12 8RZGlasgow, Scotland, United Kingdom
S. Zammit
Affiliation:
Department of psychological medicine and clinical neurosciences, school of medicine, Cardiff university, Cardiff, Wales, United Kingdom
D.J. Smith
Affiliation:
Institute of health & wellbeing, university of Glasgow 1, Lilybank Gardens, G12 8RZGlasgow, Scotland, United Kingdom
*
*Corresponding author. Tel.: +0141 330 2567. E-mail address:[email protected] (D.F. Mackay).
Get access

Abstract

Objectives

Using data from a prospective birth cohort, we aimed to test for an association between exposure to tobacco smoke in utero or during early development and the experience of hypomania assessed in young adulthood.

Methods

We used data on 2957 participants from a large birth cohort (Avon longitudinal study of parents and children [ALSPAC]). The primary outcome of interest was hypomania, and the secondary outcome was “hypomania plus previous psychotic experiences (PE)”. Maternally-reported smoking during pregnancy, paternal smoking and exposure to environmental tobacco smoke (ETS) in childhood were the exposures of interest. Multivariable logistic regression was used and estimates of association were adjusted for socio-economic, lifestyle and obstetric factors.

Results

There was weak evidence of an association between exposure to maternal smoking in utero and lifetime hypomania. However, there was a strong association of maternal smoking during pregnancy within the sub-group of individuals with hypomania who had also experienced psychotic symptoms (OR = 3.45; 95% CI: 1.49–7.98; P = 0.004). There was no association between paternal smoking, or exposure to ETS during childhood, and hypomania outcomes.

Conclusions

Exposure to smoking in utero may be a risk factor for more severe forms of psychopathology on the mood-psychosis spectrum, rather than DSM-defined bipolar disorder.

Keywords

TobaccoPsychosesPost-partumNicotineBipolar disorder
Type
Original article
Information
European Psychiatry , Volume 39 , January 2017 , pp. 33 - 39
Copyright
Copyright © Elsevier Masson SAS 2017

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Mackay, DHaw, SAyres, JGFischbacher, CPell, JPSmoke-free legislation and hospitalizations for childhood asthma. N Engl J Med 2010; 363(12): 1139–1145.CrossRefGoogle ScholarPubMed
Pell, JPHaw, SCobbe, Set al.Smoke-free legislation and hospitalizations for acute coronary syndrome. N Engl J Med 2008; 359(5): 482–491.CrossRefGoogle ScholarPubMed
Mackay, DFNelson, SMHaw, SJPell, JPImpact of Scotland's smoke-free legislation on pregnancy complications: retrospective cohort study. Plos Med 2012;9(3):e1001175.CrossRefGoogle ScholarPubMed
Been, JVNurmatov, UBCox, BNawrot, TSvan Schayck, CPSheikh, AEffect of smoke-free legislation on perinatal and child health: a systematic review and meta-analysis. Lancet 2014; 383(9928): 1549–1560.CrossRefGoogle ScholarPubMed
Cox, BMartens, ENemery, BVangronsveld, JNawrot, TSImpact of a stepwise introduction of smoke-free legislation on the rate of preterm births: analysis of routinely collected birth data. BMJ 2013;346:f441.CrossRefGoogle ScholarPubMed
Abbott, LCWinzer-Serhan, UHSmoking during pregnancy: lessons learned from epidemiological studies and experimental studies using animal models. Crit Rev Toxicol 2012; 42(4): 279–303.CrossRefGoogle ScholarPubMed
Naeye, RLPeters, ECMental development of children whose mothers smoked during pregnancy. Obstet Gynecol 1984; 64(5): 601–607.Google ScholarPubMed
Olds, DLHenderson, CRTatelbaum, RIntellectual impairment in children of women who smoke cigarettes during pregnancy. Pediatrics 1994; 93(2): 221–227.Google ScholarPubMed
Thapar, AFowler, TRice, FScourfield, Jvan den Bree, MThomas, Het al.Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring. Am J Psychiatry 2003; 160(11): 1985–1989.CrossRefGoogle ScholarPubMed
Zammit, SThomas, KThompson, AHorwood, JMenezes, PGunnell, Det al.Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring. Br J Psychiatry 2009; 195(4): 294–300.CrossRefGoogle ScholarPubMed
Stathopoulou, ABeratis, INBeratis, SPrenatal tobacco smoke exposure, risk of schizophrenia, and severity of positive/negative symptoms. Schizophr Res 2013;148(1–3):105–110.CrossRefGoogle ScholarPubMed
Niemelä, SSourander, ASurcel, HMHinkka-Yli-Salomäki, SMcKeague, IWCheslack-Postava, Ket al., Prenatal nicotine exposure and risk of schizophrenia among offspring in a National birth cohort. Am J Psychiatry 0(0): p. appi.ajp.2016.15060800.Google Scholar
Ekblad, MGissle, MLehtonen, LKorkeila, JPrenatal smoking exposure and the risk of psychiatric morbidity into young adulthood. Arch Gen Psychiatry 2010; 67(8): 841–849.CrossRefGoogle ScholarPubMed
Ekblad, MKorkeila, JLehtonen, LSmoking during pregnancy affects foetal brain development. Acta Paediatr 2015; 104(1): 12–18.CrossRefGoogle ScholarPubMed
Dwyer, JBBroide, RSLeslie, FMNicotine and brain development. Birth Defects Res Part C Embryo Today Rev 2008; 84(1): 30–44.CrossRefGoogle ScholarPubMed
Clifford, ALang, LChen, REffects of maternal cigarette smoking during pregnancy on cognitive parameters of children and young adults: a literature review. Neurotoxicol Teratol 2012; 34(6): 560–570.CrossRefGoogle Scholar
Talati, ABao, YKaufman, JSchaefer, CABrown, ASMaternal smoking during pregnancy and bipolar disorder in offspring. Am J Psychiatry 2013; 170(10): 1178–1185.CrossRefGoogle ScholarPubMed
Fraga, DBDeroza, PFGhediim, FVSteckert, AVDe Luca, RDSilverio, Aet al., Prenatal exposure to cigarette smoke causes persistent changes in the oxidative balance and in DNA structural integrity in rats submitted to the animal model of schizophrenia. J Psychiatr Res 45(11):1497–503.CrossRefGoogle Scholar
Lee, KWRichmond, RHu, PFrench, LShin, JBourdon, Cet al.Prenatal exposure to maternal cigarette smoking and DNA methylation: epigenome-wide association in a discovery sample of adolescents and replication in an independent cohort at birth through 17 years of age. Environ Health Perspect 2015; 123: 193–199.CrossRefGoogle Scholar
Chudal, RBrown, ASGissler, MSuominen, ASourander, AIs maternal smoking during pregnancy associated with bipolar disorder in offspring?. J Affect Disord 2015; 171: 132–136.CrossRefGoogle ScholarPubMed
Fraser, AMacdonald-Wallis, CTilling, KBoyd, AGolding, JSmith, GDet al.Cohort profile: the Avon longitudinal study of parents and children: ALSPAC mothers cohort. Int J Epidemiol 2013CrossRefGoogle ScholarPubMed
Niarchou, MZammit, SLewis, GThe Avon longitudinal study of parents and children (ALSPAC) birth cohort as a resource for studying psychopathology in childhood and adolescence: a summary of findings for depression and psychosis. Soc Psychiatry Psychiatr Epidemiol 2015; 50(7): 1017–1027.CrossRefGoogle ScholarPubMed
Angst, JAdolfsson, RBenazzi, FGamma, AHantouche, EMeyer, TDet al.The HCL-32: towards a self-assessment tool for hypomanic symptoms in outpatients. J Affect Disord 2005; 88(2): 217–233.CrossRefGoogle ScholarPubMed
Carvalho, AFTakwoingi, YSales, PMSoczynska, JKKöhler, CAFreitas, THet al.Screening for bipolar spectrum disorders: a comprehensive meta-analysis of accuracy studies. J Affect Disord 2015; 172: 337–346.CrossRefGoogle ScholarPubMed
Court, HForty, LJones, LGordon-Smith, KJones, ICraddock, Net al.Improving the psychometric utility of the hypomania checklist (HCL-32): a Rasch analysis approach. J Affect Disord 2014;152-154:448–453.CrossRefGoogle ScholarPubMed
Meyer, TDHammelstein, PNilsson, LGSkeppar, PAdolfsson, RAngst, JThe hypomania checklist (HCL-32): its factorial structure and association to indices of impairment in German and Swedish non-clinical samples. Compr Psychiatry 2007; 48(1): 79–87.CrossRefGoogle Scholar
Meyer, TDSchrader, JRidley, MLex, CThe hypomania checklist (HCL) – Systematic review of its properties to screen for bipolar disorders. Compr Psychiatry 2014; 55(5): 1310–1321.CrossRefGoogle ScholarPubMed
Hardoy, MCCM, Cadeddu, MMurru, ADell’Osso, BMorosini, PLCalabrese, JRValidation of the Italian version of the “Mood Disorder Questionnaire” for the screening of bipolar disorders. Clin Pract Epidemiol Mental Health 2005;1(8).Google ScholarPubMed
Goldberg, JFPerlis, RHBowden, CLThase, MEMiklowitz, DJMarangell, LBet al.Manic symptoms during depressive episodes in 1380 patients with bipolar disorder: findings from the STEP-BD. Am J Psychiatry 2009; 166(2): 173–181.CrossRefGoogle ScholarPubMed
Pini, Sde Queiroz, VPagnin, DPezawas, LAngst, JCassano, GBet al.Prevalence and burden of bipolar disorders in European countries. Eur Neuropsychopharmacol 2005; 15(4): 425–434.CrossRefGoogle ScholarPubMed
Benazzi, FIs four days the minimum duration of hypomania in bipolar II disorder?. Eur Arch Psychiatry Clin Neurosci 2001; 251: 32–34.CrossRefGoogle Scholar
Angst, JCassano, GThe mood spectrum: improving the diagnosis of bipolar disorder. Bipolar Disord 2005;7(Suppl. 4):4–12.CrossRefGoogle Scholar
Holtmann, MPörtner, FDuketis, EFlechtner, H-HAngst, JLehmkuhl, GValidation of the hypomania checklist (HCL-32) in a non-clinical sample of German adolescents. J Adolesc 2009; 32(5): 1075–1088.CrossRefGoogle Scholar
Zammit, SOdd, DHorwood, JThompson, AThomas, KMenezes, Pet al.Investigating whether adverse prenatal and perinatal events are associated with non-clinical psychotic symptoms at age 12 years in the ALSPAC birth cohort. Psychol Med 2009; 39(9): 1457–1467.CrossRefGoogle ScholarPubMed
Zammit, SOdd, DHorwood, JThompson, AThomas, KMenezes, Pet al.Psychotic experiences and psychotic disorders at age 18 in relation to psychotic experiences at age 12 in a longitudinal population-based cohort study. Am J Psychiatry 2013; 170(7): 742–750.CrossRefGoogle Scholar
Thompson, AHorwood, JSalvi, GThomas, KDuffy, LGunnell, Det al.IQ and non-clinical psychotic symptoms in 12-year-olds: results from the ALSPAC birth cohort 2008; 193: 185–191.Google Scholar
Simanek, AMMeier, HCSAssociation between prenatal exposure to maternal infection and offspring mood disorders: a review of the literature. Curr Probl Pediatr Adolesc Health Care 2015; 45: 325–364.CrossRefGoogle ScholarPubMed
Parboosing, RBao, YShen, LSchaefer, CABrown, ASGestational influenza and bipolar disorder in adult offspring. JAMA Psychiatry 2013; 70: 677–685.CrossRefGoogle ScholarPubMed
Canetta, SEBao, YEnnis, FACruz, JTerajima, MShen, Let al.Serological documentation of maternal influenza exposure and bipolar disorder in adult offspring. Am J Psychiatry 2014; 171: 557–563.CrossRefGoogle ScholarPubMed
Anderson, JJHoath, SZammit, SMeyer, TDPell, JPMackay, Det al.Gestational influenza and risk of hypomania in young adulthood: prospective birth cohort study. J Affect Disord 2016; 200: 182–188.CrossRefGoogle ScholarPubMed
Niemelä, SSourander, ASurcel, HMHinkka-Yli-Salomäki, SMcKeague, IWCheslack-Postava, Ket al.Prenatal nicotine exposure and risk of schizophrenia among offspring in a National birth cohort. Am J Psychiatry 0(0): p. appi.ajp.2016.15060800.Google Scholar
Vieta, ESanchez-Moreno, JBulbena, AChamorro, LRamos, JLArtal, Jet al.Cross-validation with the mood disorder questionnaire (MDQ) of an instrument for the detection of hypomania in Spanish: the 32-item hypomania symptom check list (HCL-32). J Affect Disord 2007;101(1–3):43–55.CrossRefGoogle Scholar
Cuthbert, BTInsel. Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Med 2013; 11(1): 126CrossRefGoogle ScholarPubMed
Insel, TThe NIMH research domain criteria (RDoC) project: precision medicine for psychiatry. Am J Psychiatry 2014; 171(4): 395–397.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.