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Exploring the Restoration of Brain Connectivity during Weight Normalization in Severe Anorexia Nervosa

Published online by Cambridge University Press:  19 July 2023

L.-K. Kaufmann
L.-K. Kaufmann*
Affiliation:
Donders Institute for Brain Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands

Abstract

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Abstract

Anorexia nervosa is a persistent and often difficult to treat eating disorder with significant physical and mental health consequences. While it is known that the disorder is associated with alterations in brain functional connectivity during the phase of acute underweight, the effect of weight normalization on brain connectivity remains unclear.

This talk focuses on the recovery of intrinsic brain connectivity during weight normalization in severe anorexia nervosa, presenting data from a longitudinal study. Using resting-state functional magnetic resonance imaging, we assessed brain connectivity at three different stages of inpatient treatment. Our findings indicate that patients with severe anorexia nervosa have weaker intrinsic connectivity and altered network topology, which do not improve during treatment. These persistent disruptions in brain networks suggest that severe anorexia nervosa may have long-term effects on the way the brain processes information, even after weight is restored.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S10
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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