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Exploring the association between brain-derived neurotrophic factor (BDNF) levels and longitudinal psychopathological and cognitive changes in Sardinian psychotic patients

Published online by Cambridge University Press:  01 September 2022

U. Isayeva ,
M. Manchia ,
D. Primavera ,
L. Deriu ,
E. Caboni ,
N. Iaselli ,
D. Sundas ,
M. Tusconi ,
R. Collu  and
M. Scherma
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U. Isayeva*
Affiliation:
University of Cagliari, Section Of Psychiatry, Department Of Medical Sciences And Public Health, Cagliari, Italy University of Cagliari, Division Of Neuroscience And Clinical Pharmacology, Department Of Biomedical Sciences, Cagliari, Italy
M. Manchia
Affiliation:
University of Cagliari, Section Of Psychiatry, Department Of Medical Sciences And Public Health, Cagliari, Italy Dalhousie University, Department Of Pharmacology, Halifax, Canada
D. Primavera
Affiliation:
University of Cagliari, Section Of Psychiatry, Department Of Medical Sciences And Public Health, Cagliari, Italy University of Cagliari, Division Of Neuroscience And Clinical Pharmacology, Department Of Biomedical Sciences, Cagliari, Italy
L. Deriu
Affiliation:
University of Cagliari, Section Of Psychiatry, Department Of Medical Sciences And Public Health, Cagliari, Italy
E. Caboni
Affiliation:
University of Cagliari, Section Of Psychiatry, Department Of Medical Sciences And Public Health, Cagliari, Italy
N. Iaselli
Affiliation:
University of Cagliari, Section Of Psychiatry, Department Of Medical Sciences And Public Health, Cagliari, Italy
D. Sundas
Affiliation:
University of Cagliari, Section Of Psychiatry, Department Of Medical Sciences And Public Health, Cagliari, Italy
M. Tusconi
Affiliation:
University of Cagliari, Section Of Psychiatry, Department Of Medical Sciences And Public Health, Cagliari, Italy
R. Collu
Affiliation:
University of Cagliari, Division Of Neuroscience And Clinical Pharmacology, Department Of Biomedical Sciences, Cagliari, Italy
M. Scherma
Affiliation:
University of Cagliari, Division Of Neuroscience And Clinical Pharmacology, Department Of Biomedical Sciences, Cagliari, Italy
A. Squassina
Affiliation:
University of Cagliari, Division Of Neuroscience And Clinical Pharmacology, Department Of Biomedical Sciences, Cagliari, Italy
D. Congiu
Affiliation:
University of Cagliari, Division Of Neuroscience And Clinical Pharmacology, Department Of Biomedical Sciences, Cagliari, Italy
W. Fratta
Affiliation:
University of Cagliari, Division Of Neuroscience And Clinical Pharmacology, Department Of Biomedical Sciences, Cagliari, Italy University of Cagliari, Centre Of Excellence “neurobiology Of Dependence”, Cagliari, Italy
P. Fadda
Affiliation:
University of Cagliari, Division Of Neuroscience And Clinical Pharmacology, Department Of Biomedical Sciences, Cagliari, Italy University of Cagliari, Centre Of Excellence “neurobiology Of Dependence”, Cagliari, Italy
B. Carpiniello
Affiliation:
University of Cagliari, Section Of Psychiatry, Department Of Medical Sciences And Public Health, Cagliari, Italy
*
*Corresponding author.

Abstract

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Introduction

Schizophrenia spectrum disorders are among the most debilitating mental disorders and evidence on its pathophysiological underpinnings is scant. The brain-derived neurotrophic factor (BDNF) appears to be involved in the pathophysiology of these complex psychiatric disorders.

Objectives

The present study investigates the longitudinal variation of serum BDNF levels in a 24-month observational cohort study of Sardinian psychotic patients (LABSP). This study assessed the variation in BDNF serum levels and its relationship with psychopathological and cognitive changes. Further, we also examined if genetic variations within the BDNF gene could moderate these relationships.

Methods

Every six months 105 LABSP patients were assessed for their BDNF serum levels, as well as for a series of psychopathological, cognitive, and drug-related measures. Four tag single nucleotide polymorphisms (SNPs) within the BDNF gene were selected and analyzed using Polymerase Chain Reaction (PCR). Longitudinal data were analyzed using mixed-effects linear regression models (MLRM).

Results

Analysis showed significantly lower peripheral BDNF levels in psychotic patients with depressive and negative symptoms. BDNF levels were also decreased in patients scoring lower in cognitive measures such as symbol coding and semantic fluency. In addition, Val66Met polymorphism within the BDNF gene significantly moderated the relationship between the severity of negative symptoms and BDNF levels.

Conclusions

Our findings are consistent with previous literature suggesting that peripheral BDNF levels are associated with some cognitive domains and mood disruption in major psychosis. The results also suggest the lack of association between most BDNF genetic variants, except Val66Met polymorphism, with the severity of negative symptoms.

Disclosure

No significant relationships.

Keywords

schizophréniabdnfbiomarkerPsychosis
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S154
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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