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The evaluation of the severity of illness, affective blunting and neuroleptic treatment outcome in schizophrenic subgroups

Published online by Cambridge University Press:  16 April 2020

M Jarema  and
J Kacperczyk
M Jarema
Affiliation:
III Department of Psychiatry, Institute of Psychiatry and Neurology, Al Sobieskiego 1/9, 02957Warsaw
J Kacperczyk
Affiliation:
Division of Psychopathology, Medical Academy, Szczecin, Poland
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Summary

In 61 schizophrenic patients divided into subgroups according to DSM III-R, positive/negative symptoms and Leonhard's classification of systematic and non-systematic schizophrenia, the severity of illness (BPRS) and affective blunting (MARS and RSEB scales) were measured before and after neuroleptic therapy. The evaluation of affective blunting with the use of RSEB revealed more significant differences within schizophrenic subgroups than with the use of MARS. The severity of illness did not differentiate the subgroups studied. The affective blunting was more severe in patients with systematic than with non-systematic schizophrenia as well as in mixed and negative than in positive schizophrenia. The severity of illness correlated however with the severity of affective blunting. Clinical improvement after neuroleptic treatment was more favorable in patients with positive schizophrenia. The diminution of affective blunting after neuroleptic therapy varied among the subgroups.

Keywords

schizophrenic subgroupaffective bluntingneuroleptic treatment outcome
Type
Original article
Information
European Psychiatry , Volume 8 , Issue 3 , 1993 , pp. 153 - 161
Copyright
Copyright © Elsevier, Paris 1993

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References

Abrams, RTaylor, MA (1978) A rating scale for emotional blunting. Am J Psychiatr 135, 226–229Google ScholarPubMed
Alpert, MRush, M (1983) Comparison of affects in Parkinson's disease and schizophrenia. Psychopharmacol Bull 19, 118–120Google Scholar
Andreasen, NC (1979) Affective flattening and the criteria for schizophrenia. Am J Psychiatr 136, 944–947Google Scholar
Andreasen, NCOlsen, S (1982) Negative vs positive schizophrenia. Arch Gen Psychiatr 39, 787–794CrossRefGoogle Scholar
Andreasen, NCFlaum, MSwayze, VWTyrrell, GArndt, S (1990) Positive and negative symptoms in schizophrenia, Arch Gen Psychiatr 47 615–621CrossRefGoogle Scholar
Arndt, SAlliger, RJAndreasen, NC (1991) The distinction of positive and negative symptoms. The failure of a two-dimensional model. Br J Psychiatr 158, 317–322CrossRefGoogle ScholarPubMed
Ban, TA (1987) Prolegomenon to the clinical prerequisite: psychopathology and the clinical classification of mental disorders. Prog Neuropsychopharmacol Biol Psychiatr 11,527–580CrossRefGoogle Scholar
Bellack, ASMorrison, RLWixted, JTMuester, KT(1990) An analysis of social competence in schizophrenia, Br J Psychiatr 156, 809–818CrossRefGoogle Scholar
Boeringa, ACastellani, S (1982) Reliability and validity of emotional blunting as a criterion for diagnosis of schizophrenia. Am J Psychiatr 139, 1131–1135Google ScholarPubMed
Brown, KWWhile, T (1992) Syndromes of chronic schizophrenia and some clinical correlates. Br J Psychiatr 161, 317–322CrossRefGoogle ScholarPubMed
Cancro, R (1992) The necessity of physiological subtyping in schizophrenia. Clin Neuropharmacol 15, Suppl 1A, 21CrossRefGoogle Scholar
Carpenter, WT JrHeinrichs, DWWagman, AMI (1988) Deficit and nondeficit forms of schizophrenia: the concept. Am J Psychiatr 145, 578–583Google Scholar
DSM III-R (1987) Diagnostic and statistical manual for mental disorders. Third edition, revised. American Psychiatric Association, Washington DCGoogle Scholar
Dworkin, RH (1992) Affective deficits and social deficits in schizophrenia: what's what? Schizophren Bull 18, 59–64CrossRefGoogle Scholar
Fenton, WSMcGlashan, TH (1991) Natural history of schizophrenia subtypes. II. Positive and negative symptoms and long-term course. Arch Gen Psychiatr 48, 978–986CrossRefGoogle ScholarPubMed
Garver, DL (1987) Methodological issues facing the interpretation of high-risk studies: biological heterogeneity. Schizophren Bull 18, 525–529CrossRefGoogle Scholar
Gerbaldo, HSchneider, BPhillip, M (1992) Subtypes of negative symptoms. Clin Neuropharmacol 15, Suppl 1B, 255CrossRefGoogle Scholar
Goldberg, SC (1985) Negative and deficit symptoms in schizophrenia do respond to neuroleptics. Schizophren Bull 1985, 11, 453–456CrossRefGoogle ScholarPubMed
Jarema, MKacperczyk, JKruszynski, S (1991) The predictive value of psychopathological subclassifications for the neuroleptic treatment outcome in schizophrenia. Psychopathol 24, 141–146CrossRefGoogle Scholar
Keks, NAHill, CJackson, HKulkarni, JCopolov, DSingh, B (1992) Symptomatic response to antipsychotics differs between recent onset and recurrent chronic schizophrenic patients. Clin Neuropharmacol 15, Suppl 1B, 135CrossRefGoogle Scholar
Kulhara, PChadda, R (1987) Study of negative symptoms in schizophrenia and depression. Comprehens Psychiatr 28, 229–235CrossRefGoogle ScholarPubMed
Kulhara, PAvasthi, AChadda, RChandiramani, KMattoo, SKKota, SKJoseph, S (1989) Negative and depression symptoms in schizophrenia. Br J Psychiatr 154, 207–211CrossRefGoogle Scholar
Lee, SLeung, H (1991) Negative symptoms of schizophrenia. Br J Psychiatr 159, 728–729CrossRefGoogle ScholarPubMed
Leonhard, K (1979) The Classification of Endogenous Psychoses. Irvington, New YorkGoogle Scholar
Lewis, S (1992) Sex and schizophrenia: vive la différence. Br J Psychiatr 161, 445–450CrossRefGoogle ScholarPubMed
Liddle, PFBarnes, TRE (1990) Syndromes of chronic schizophrenia. Br J Psychiatr 157, 558–561CrossRefGoogle ScholarPubMed
McLaren, SCookson, JCSilverstone, T (1992) Positive and negative symptoms, depression and social disability in chronic schizophrenia: a comparative trial of bromperidol and fluphenazine decanoates. Int J Clin Psychopharmacol 7, 67–72Google ScholarPubMed
Maj, MKemali, D (1991) Reciprocal influences between clinical and biological research in shaping the modern concept of schizophrenia. Eur Psychiatr 6, 109–114Google Scholar
Mortimer, AM (1992) Phenomenology, its place in schizophrenia research. Br J Psychiatr 161, 293–297CrossRefGoogle ScholarPubMed
Overall, JEGorham, DR (1962) The brief psychiatric rating scale. Psychol Rep 10, 799–812CrossRefGoogle Scholar
Peralta, Vde Leon, JCuesta, MJ (1992) Are there more than two syndromes in schizophrenia? A critique of the positive-negative dichotomy. Br J Psychiatr 161, 335–343CrossRefGoogle ScholarPubMed
Petho, BBan, TAKeleman, AKarczag, IBitter, ITolna, JJarema, MFerrero, FAguglia, EZurria, GLFjetland, O (1988) DCR Budapest-Nashville in the diagnosis and classification of functional psychoses. Psychopathol 21, 135–240Google ScholarPubMed
Phillips, MRZhao, ZXiong, XCheng, XSun, GWu, N (1991) Changes in the positive and negative symptoms of schizophrenic in-patients in China. Br J Psychiatr 159, 226–231CrossRefGoogle Scholar
Pickar, DHsiao, JKLitman, RE (1992) Regional brain metabolism as predictors of clozapine response. Clin Neuropsychopharmacol 15, Suppl 1A, 399CrossRefGoogle ScholarPubMed
Pogue-Geile, MFHarrow, M (1984) Negative and positive symptoms in schizophrenia and depression: a follow-up. Schizophren Bull 10, 371–387CrossRefGoogle Scholar
Pogue-Geile, MFHarrow, M (1985) Negative symptoms in schizophrenia: their longitudinal course and prognostic importance, Schizophren Bull 11, 427–439CrossRefGoogle ScholarPubMed
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