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Evaluation of Brain Functions in Conversion Disorder with PET/MRI

Published online by Cambridge University Press:  01 September 2022

S.Z. Tatlı ,
E. Özkan ,
M. Araz ,
M.İ. Erden  and
V. Şentürk Cankorur
S.Z. Tatlı*
Affiliation:
Ankara University Faculty of Medicine, Psychiatry, Ankara, Turkey
E. Özkan
Affiliation:
Ankara University Faculty of Medicine, Nuclear Medicine, Ankara, Turkey
M. Araz
Affiliation:
Ankara University Faculty of Medicine, Nuclear Medicine, Ankara, Turkey
M.İ. Erden
Affiliation:
Ankara University Faculty of Medicine, Radiology, Ankara, Turkey
V. Şentürk Cankorur
Affiliation:
Ankara University Faculty of Medicine, Psychiatry, Ankara, Turkey
*
*Corresponding author.

Abstract

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Introduction

Since there is no objective criteria, unique clinical symptom or laboratory test to make the diagnosis of conversion disorder; its diagnosis and treatment is challenging which leads to a poor prognosis.

Objectives

The aim of this study is to investigate the brain metabolic activity of patients with conversion disorder with PET/MRI.

Methods

12 conversion disorder patients were included. Somatosensory Amplification Scale, Somatoform Dissociation Scale, Patient Health Questionnaire-15, Toronto Alexithymia Scale were filled in by the participants. Neurological, mental status examinations, Wechsler Adult Intelligence Scale-Revised Form (WAIS-R) and brain F18-FDG-PET/MRI were performed. Structured Clinical Interview for DSM-5, Hamilton Depression and Anxiety Scales were administered.

Results

83% of the patients were female, the mean age was 33 years and average education period was 10,2 years. WAIS-R total scores were consistent with low avarage intelligence level.Cerebral hypermetabolism was detected in the primary visual cortex. Average regional brain metabolic activity had a tendency to increase in bilateral prefrontal, right sensorimotor (SM),cingulate,right inferior parietal,occipital lateral,right temporal lateral cortices and cerebellum. Each region was metabolically correlated with the homologous contralateral regions. Significant correlations in the same direction was found between frontal and occipital lateral & primary visual cortices; cerebellum and left sensorimotor cortex; anterior cingulate cortex(ACC) and superior parietal cortex & cerebellum. No correlations were found between ACC and left SM cortex.

Conclusions

Findings of our study indicate that there are moderate changes in regional brain metabolic activities and inter-regional correlations in patients with conversion disorder. In order to confirm these findings, furter functional neuroimaging studies are needed.

Disclosure

No significant relationships.

Keywords

NeuroimagingConversion DisorderBrain metabolismPET/MRI
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S220
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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