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EPA-1742 – The Effect of Qing Huan Ling Containing Serum on Proliferation and Morphology of Human Neuroblastoma SH-SY5Y Cells

Published online by Cambridge University Press:  15 April 2020

Y. Zhang ,
Q.J. Wu ,
B. Wu  and
F.H. Liu
Y. Zhang
Affiliation:
Central laboratory, Xi’an mental health center, Xi’an, China
Q.J. Wu
Affiliation:
the dean, Xi’an mental health center, Xi’an, China
B. Wu
Affiliation:
Vice the dean, Xi’an mental health center, Xi’an, China
F.H. Liu
Affiliation:
science and education department, Xi’an mental health center, Xi’an, China

Abstract

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Objective

To investigate the effect of Qing huan ling containing serum on proliferation and morphology of human neuroblastoma SH-SY5Y cells.

Methods

7 consecutive days gavaged Qing huan ling or Risperidone to rabbit for preparation of Qing huan ling, or risperidone drug-containing rabbit serum. The morphology of SH-SY5Y cells was observed by inverted microscope after 48 hours drug-containing serum treated, and every 24h proliferation of SH-SY5Y cell was tested by the MTT assay.

Results

Qing huan ling containing serum treated 48h SH-SY5Y cell, were close contact between the cells, have pseudopodia, and promote proliferation. Qing huan ling containing serum compared with the blank serum on proliferation of SH-SY5Y cells not statistically significant (P> 0.05), but risperidone containing serum can be a significant increase in the number of SH-SY5Y cells, showing the logarithmic growth trend (P <0.05).

Conclusion

Qing huan ling containing serum can promote on the normal form of the SH-SY5Y cells, on normal proliferation of SH-SY5Y cells without significant intervention, different from the risperidone role.

Type
P27 - Psychopharmacology and Pharmacoeconomics
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014
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