Hostname: page-component-586b7cd67f-2brh9 Total loading time: 0 Render date: 2024-11-30T03:31:41.201Z Has data issue: false hasContentIssue false
  • English
  • Français

EPA-1638 – Neurofeedback Using Real-time Fmri in Patients with Alcohol Use Disorder

Published online by Cambridge University Press:  15 April 2020

S. Hümmer ,
S. Karch ,
D. Keeser ,
M. Paolini ,
V. Kirsch ,
G. Koller ,
B. Rauchmann ,
M. Kupka ,
J. Blautzik  and
O. Pogarell
S. Hümmer
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany
S. Karch
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany
D. Keeser
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany
M. Paolini
Affiliation:
Institute of Clinical Radiology, Ludwig- Maximilians-University, Munich, Germany
V. Kirsch
Affiliation:
Department of Neurology, Ludwig-Maximilians-University, Munich, Germany
G. Koller
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany
B. Rauchmann
Affiliation:
Institute of Clinical Radiology, Ludwig- Maximilians-University, Munich, Germany
M. Kupka
Affiliation:
Institute of Clinical Radiology, Ludwig- Maximilians-University, Munich, Germany
J. Blautzik
Affiliation:
Institute of Clinical Radiology, Ludwig- Maximilians-University, Munich, Germany
O. Pogarell
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Several previous studies have shown that real-time neurofeedback can be used to willfully regulate neuronal activity in specific brain-regions. The aim of the study was to find out whether patients with alcohol dependency would be able to learn how to regulate their neuronal activity in dependency-associated areas. In addition, neurofeedback-related variations to craving for alcohol are assessed.

11 patients with alcohol dependency and 14 healthy participants were investigated. Neutral and alcohol-associated pictures were presented during functional MRI measurements. Alcohol-associated BOLD-responses in the frontal cortex (anterior cingulate cortex, dorsolateral prefrontal cortex, insula) were used as a region of interest (ROI). During the neurofeedback sessions, participants were instructed to down regulate their neuronal activity in the specific ROI during the presentation of alcohol-associated pictures.

The results show that the patients were able to regulate their neuronal activities in areas related to dependency (p=0,048). After the neurofeedback-sessions, the individual craving (valued on the basis of the obsessive compulsive drinking scale) was slightly reduced in comparison to before the sessions (p=0,068).

It seems feasible for patients with alcohol dependency to down-regulate their neuronal activity using rtfMRI. In addition, there is some evidence that craving can be influenced by this technique. However, so far, there were great differences within the group of patients.

Type
E08 - e-Poster Oral Session 08: Schizophrenia, Affective disorders, Addiction
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014
Submit a response

Comments

No Comments have been published for this article.