EPA-1301 - Neurobiological Factors in Suicidal Behavior in Patients with Depressive Disorders

Abstract

Introduction:

Suicide is a major cause of disability and mortality.

Aims:

Examine the role of neurobiological factors of suicidal behavior, includingneyrotransmitternyh and neurohormonal systems, which include the metabolism ofbiogenic amines.

Objectives:

55patients aged 17 - 35 years of both sexes (58 men and 97 women) who havecommitted suicide

Methods:

Clinicalexamination, biochemical and immunogenetical methods.

Results:

Found thattheir violation and imbalance, namely increased concentrations of serotonin inthe blood (2,39 ± 0,24 mmol / l) reduction in plasma melatonin (0,71 ± 0,07 mmol / l) and decreasedexcretion rate adrenaline and noradrenaline at night (0,39 ± 0,06 and 1,21 ± 0,25 mmol / h) and daytime periods(1,66 ± 0,26and 4,56 ± 0,86 mmol/ h), creates neurohormonal background for the development of psychopathologicalconditions that lead to suicidal intentions and actions.

Conclusions:

Patientswith specified neurobiological changes have been unable to get out of the longconflict through active variant of overcoming conflict and completed suicidalacts. According to the results of biomedical research, with to appropriatecorrection is differentiated use of natural biogenic stimulants herbalantidepressant that selectively affect the turnover of serotonin, melatonin, or drugs that stimulate the function of epiphysis.