Hostname: page-component-745bb68f8f-grxwn Total loading time: 0 Render date: 2025-01-14T12:41:56.692Z Has data issue: false hasContentIssue false
  • English
  • Français

EPA-0510 - A comparison of the Effect of Morphine and Fentanyl Derivatives on the Antinociception and body Temperature in Rats

Published online by Cambridge University Press:  15 April 2020

K. Savic Vujovic ,
A. Vujovic ,
S. Vuckovic ,
D. Srebro ,
B. Medic  and
M. Prostran
K. Savic Vujovic
Affiliation:
Department of Pharmacology Clinical Pharmacology and Toxicology, Faculty of Medicine University, of Belgrade
A. Vujovic
Affiliation:
Hospital for ENT, KBC Dragisa Misovic, Belgrade, Serbia
S. Vuckovic
Affiliation:
Department of Pharmacology Clinical Pharmacology and Toxicology, Faculty of Medicine University, of Belgrade
D. Srebro
Affiliation:
Department of Pharmacology Clinical Pharmacology and Toxicology, Faculty of Medicine University, of Belgrade
B. Medic
Affiliation:
Department of Pharmacology Clinical Pharmacology and Toxicology, Faculty of Medicine University, of Belgrade
M. Prostran
Affiliation:
Department of Pharmacology Clinical Pharmacology and Toxicology, Faculty of Medicine University, of Belgrade

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction:

In addition to producing antinociception, opioids exert profound effects on body temperature.

Aim:

This study aimed at comparing antinociceptive and hyperthermic responses between two groups of μ-opioid receptor agonists: fentanyl (4- anilinopiperidine-type) and morphine (phenanthrene-type) derivatives in rats.

Methods:

Analgesic activity was assessed by tail-immersion test in male Wistar rats (200–250 g). The distal 5 cm of the tail was immersed in a warm water bath (55 + 0.5°C) and the time for tail-withdrawal was measured as a response latency. The body temperature was measured by insertion of a thermometer probe 5 cm into the colon of unrestrained rats.

Results:

Fentanyl (F), (±)cis-3-methyl fentanyl (CM), (±)cis-3-carbomethoxy fentanyl (C), (±)trans-3-carbomethoxy fentanyl (T) and (±)cis-3 butyl fentanyl (B) produced dose-dependent increase in antinociception and hyperthermia. The relative order of analgesic potency was: CM(11.27)>F(1)>C(0.35)3T(0.11)3B (0.056). Similar to this, the relative order of hyperthermic potency was: CM(8.43)>F(1)>C(0.46)3T(0.11)3B(0.076). Morphine (M), oxycodone (O), thebacon (T) and 6,14-Ethenomorphinan-7-methanol, 4,5-epoxy-6- fluoro-3-hydroxy-a, a,17-trimethyl-, (5a,7a) (E) also produced dose-dependent increase in antinociception and hyperthermia. Among morphine derivatives the relative order of analgesic potency was: E(56)>O(5)3T(2.6)>M(1), and similar to this, the relative order of hyperthermic potency was: E(37)>O(3)3T(2.3)>M(1).

Conclusion:

Morphine (phenanthrene-type) and fentanyl (4-anilinopiperidine-type) derivatives produced hyperthermia in rats at doses about 2 times lower, and 6 to 11 times higher, than their median antinociceptive doses, respectively. This study is first to identify difference between these two classes of opioid drugs in their potencies in producing hyperthermia.

Type
EPW30 - Psychiatry and Somatic diseases
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014
Submit a response

Comments

No Comments have been published for this article.