Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-30T04:37:06.854Z Has data issue: false hasContentIssue false
  • English
  • Français

EPA-0163 – The Adverse Children Experience in Sjogren's Syndrome Adult Patients Suffering Mental Disorders

Published online by Cambridge University Press:  15 April 2020

O. Shelomkova ,
D. Veltishchev ,
V. Vasiliev ,
T. Lisitsyna ,
O. Kovalevskaya ,
O. Seravina ,
V. Krasnov  and
E. Nasonov
O. Shelomkova
Affiliation:
Stress -Related Disorders, Moscow Research Institute of Psychiatry MoH RF, Moscow, Russia
D. Veltishchev
Affiliation:
Stress -Related Disorders, Moscow Research Institute of Psychiatry MoH RF, Moscow, Russia
V. Vasiliev
Affiliation:
Laboratory Iintensive Therapy of Rheumatic Diseases, Research Institute of Rheumatology RAMS, Moscow, Russia
T. Lisitsyna
Affiliation:
Laboratory of Systemic Rheumatic Diseases Department of Vascular Disease, Research Institute of Rheumatology RAMS, Moscow, Russia
O. Kovalevskaya
Affiliation:
Stress -Related Disorders, Moscow Research Institute of Psychiatry MoH RF, Moscow, Russia
O. Seravina
Affiliation:
Stress -Related Disorders, Moscow Research Institute of Psychiatry MoH RF, Moscow, Russia
V. Krasnov
Affiliation:
Director of Moscow Research Institute of Psychiatry, Moscow Research Institute of Psychiatry, Moscow, Russia
E. Nasonov
Affiliation:
Director of Research Institute of Rheumatology RAMS, Research Institute of Rheumatology RAMS, Moscow, Russia

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction:

The adverse experience in childhood (parental deprivation mostly) (AEC) has an important role in predisposing to mood and immuno-inflammatory rheumatic disorders in adults via chronic stress mechanisms. The primary Sjögren's Syndrome (SS) - a chronic, systemic autoimmune disease, which has some common pathogenic links with stress-related mental disorders.

Objectives/Aims:

To evaluate the AEC and MD presentation in SS patients.

Methods:

80 inpatients (mean age 46,2+12,3 yrs) suffering SS were enrolled in the study. MD were diagnosed in accordance with ICD-10 criteria. The severity of depression, anxiety, stress were measured with HADS, MADRS, HAM-A, PSS-10.

Results:

The AEC had 78,7% of SS patients (recurrent events – 32,5%). Patients with AEC had an increased risk of developing dysthymia (OR=1,34; 95% CI=0,26–6,83) and depressive episode (OR=1,75 (0,35–8,65)) in adults. Recurrent depression was not revealed in patients with ACE. However, patients with AEC had no reliable differences in the MADRS, HAM-A, HADS, PSS-10 compared to patients without AEC. Patients with AEC had an increased risk of suicide attempts (OR=2,15; (0,25–37,2)) and suicidal thoughts (OR=4,58; (0,25–18,5)). The reliable correlations of the severity of SS symptoms (dry eyes/mouth, lymphoma) and AEC have not been confirmed. Patients with AEC had early onset SS (33,6±13,0 vs 38,1±14,2) and MD (28,4±12,6 vs 34,1±13,5) than patients without AEC.

Conclusion:

AE? is a significant risk factor for depression and suicidal thoughts and attempts in patients suffering SS.

Type
EPW35 - Consultation Liaison Psychiatry and Psychosomatics 3
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014
Submit a response

Comments

No Comments have been published for this article.