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Elevated Il-6 Levels Are Associated with Social Cognitive Impairment in Stable Patients with Schizophrenia.

Published online by Cambridge University Press:  15 April 2020

J. Salgado ,
B. Cruz ,
S. Campos ,
R. Ribeiro ,
A. Oliveira ,
C. Del-Ben  and
A. Teixeira
J. Salgado
Affiliation:
Morphology, Federal University of Minas Gerais, Belo Horizonte, Brazil
B. Cruz
Affiliation:
Neuroscience Post-Graduation Program, Federal University of Minas Gerais, Belo Horizonte, Brazil
S. Campos
Affiliation:
Neuroscience Post-Graduation Program, Federal University of Minas Gerais, Belo Horizonte, Brazil
R. Ribeiro
Affiliation:
Neuroscience Post-Graduation Program, Federal University of Minas Gerais, Belo Horizonte, Brazil
A. Oliveira
Affiliation:
Raul Soares Institute, FHEMIG, Belo Horizonte, Brazil
C. Del-Ben
Affiliation:
Neurociências e Ciências do Comportamento, University of Sao Paulo, Ribeirão Preto, Brazil
A. Teixeira
Affiliation:
Internal Medicine, Federal University of Minas Gerais, Ribeirão Preto, Brazil

Abstract

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Introduction

Cognitive impairment is a core feature of schizophrenia, associated with significant social and functional impairment. Schizophrenia has also been associated with inflammation and immune changes. Recently it has been showed that IL-6, a pro-inflammatory cytokine, was associated with cognitive impairment.

Objectives

The aim of this study was to assess the associations between a pro-inflammatory cytokines (IL-6) and an anti-inflammatory cytokine (IL-4) with social cognition in a sample of stable patients with schizophrenia.

Methods

Social cognition was assessed using the Face Emotion Identification Task (FEIT) and the Hinting Task in 29 stable outpatients with schizophrenia. Blood was collected and cytokines (IL-4, IL-6) assays were realized (CBA method).

Results

IL-6 levels showed a significant inverse correlation with FEIT global score (p = 0.019, rho = -0.475) and a trend of significant inverse correlation with the Hinting Task (p = 0.079, rho = -0.332). However, IL-4 levels showed no significant association with the FEIT or the Hinting task (rho = 0.079 and 0,121; respectively).

Conclusions

Elevated IL-6 levels seem to play a role in social cognitive impairment in stable patients with schizophrenia. These results should be interpreted with caution due to the limited number of participants in the study.

Type
Article: 0383
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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