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The efficacy psychobiotics for depression treatment

Published online by Cambridge University Press:  19 July 2023

Y. Denysov ,
G. Putyatin ,
S. Moroz  and
V. Semenikhina
Y. Denysov*
Affiliation:
Psychiatry, psychotherapy, addictology and medical psychology, Donetsk national medical university, Kropyvnitskyi
G. Putyatin
Affiliation:
Psychiatry, psychotherapy, addictology and medical psychology, Donetsk national medical university, Kropyvnitskyi
S. Moroz
Affiliation:
Psychiatry, Municapal Enterprise “Dnipro Multiprofile Clinical Hospital for the Provision of Psychiatric Care Dnipropetrovsk Regional Council”, Dnipro, Ukraine
V. Semenikhina
Affiliation:
Psychiatry, Municapal Enterprise “Dnipro Multiprofile Clinical Hospital for the Provision of Psychiatric Care Dnipropetrovsk Regional Council”, Dnipro, Ukraine
*
*Corresponding author.

Abstract

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Introduction

Psychobiotics are a group of probiotics that affect the central nervous system related functions and behaviors mediated by the gut-brain-axis via immune, humoral, neural, and metabolic pathways to improve not only the gastrointestinal function but also the antidepressant and anxiolytic capacity.

Objectives

To assess the efficacy the combination of selective serotonin reuptake inhibitors antidepressants (SSRI) and probiotic supplement containing Lactobacillus Plantarum CECT7485 and Lactobacillus Brevis CECT7480 (PLANTARUM) in patients with mild-to-moderate depression.

Methods

Sixty patients with mild-to-moderate depression (according to ICD-10 diagnostic criteria for mixed anxiety and depression disorder, F41.2) were included in an 8-week open label study. Thirty participants received either SSRI antidepressants with PLANTARUM at a dose of 1.0 × 109 CFU once per day. Thirty patients received SSRI antidepressants only without probiotics intake. The severity of depressive symptoms was assessed using Hamilton Depressive Rating Scale (HDRS) and Patient Health Questionnaire (PHQ-9).

Results

After 8 weeks intervention, a clinically significant reduction of HDRS total score (from 45,6±6,1 to 22,5±3,7) was detected in patients with mild-to-moderate depression who received SSRI antidepressants and PLANTARUM (p˂0,001), compared with participants who didn’t receive probiotics (p>0,05). A significant reduction of PHQ-9 total score (from 19,3±2,9 to 9,0±1,9) was identified in patients with mild-to-moderate depression who received SSRI antidepressants and PLANTARUM (p˂0,05). However, the participants received SSRI antidepressant only didn’t meet a clinically significant reduction depressive symptoms (p>0,05) by PHQ-9 scale.

Conclusions

The combination use of SSRI antidepressants and probiotic supplement PLANTARUM significantly reduced the depressive symptoms.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S607
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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