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Effects of tianeptine on attention, memory and psychomotor performances using neuropsychological methods in young healthy volunteers

Published online by Cambridge University Press:  16 April 2020

MF Poirier ,
A Galinowski ,
I Amado-Boccara ,
B Delalleau ,
N Gougoulis  and
H Lôo
MF Poirier
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Hôpital Sainte-Anne, 1, rue Cabanis, 75674Paris Cedex 14 and Paris V Cochin University
A Galinowski
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Hôpital Sainte-Anne, 1, rue Cabanis, 75674Paris Cedex 14 and Paris V Cochin University
I Amado-Boccara
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Hôpital Sainte-Anne, 1, rue Cabanis, 75674Paris Cedex 14 and Paris V Cochin University
B Delalleau
Affiliation:
IRIS, 6, Place des Pléiades, 92415Courbevoie Cedex
N Gougoulis
Affiliation:
SM 22, Hôpital Sainte-Anne, 1, rue Cabanis, 75674Paris Cedex 14, France
H Lôo
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Hôpital Sainte-Anne, 1, rue Cabanis, 75674Paris Cedex 14 and Paris V Cochin University
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Summary

A study was performed in young healthy volunteers in order to test the possible action of tianeptine, a new antidepressant drug, on cognitive performances. Attention tests, memory tests, a non-verbal inductive reasoning test and a sleep questionnaire were used in this double-blind placebo-controlled crossover study. The two one-week drug administration periods were separated by a one-week wash-out period. The methodology permitted us to evaluate the learning effect during the familiarization with the tests and to clear the results of the study from this parameter which could possibly distort analysis. For this large range of tests, the results showed that tianeptine did not affect the level of functioning of the volunteers after their familiarization with the tests. These results are in contrast with those obtained by different authors with classical tricyclic antidepressants.

Keywords

tianeptineantidepressantsmemoryattentionsleep
Type
Research Article
Information
European Psychiatry , Volume 8 , Issue S2: Neuroendocrinological aspects of depression 28 June 1992, Nice, France , 1993 , pp. 95s - 102s
Copyright
Copyright © Elsevier, Paris 1993

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References

Branconnier, RJDe Vitt, ORCole, JOSpera, KF (1982) Amitriptyline selectively disrupts verbal recall from secondary memory of the normal aged. Neurobiol Aging 3, 55–59CrossRefGoogle ScholarPubMed
Buschke, H (1973) Selective reminding for analysis of memory and learning. J Verb Learn Verb Behav 12, 543–550CrossRefGoogle Scholar
Crocq, LFondarai, JKohler, F (1984) Tests psychométriques sur micro-ordinateur.CR Congrès de Psychiatrie Neurologie. Langue Française. Luxembourg, 2-6 juillet 1984, Masson, ed, Paris, 178–182Google Scholar
Curran, MVShine, PLader, M (1986) Effects of repeated doses of fluvoxamin, mianserin and placebo on memory and measures of sedation. Psychopharmacol 89, 360–363CrossRefGoogle Scholar
Curran, HVSakulsriprong, MLader, M (1988) Antidepressant and human memory: an investigation of four drugs with different sedative and anticholinergic profiles. Psychopharmacol 95, 520–527CrossRefGoogle ScholarPubMed
Defrance, RMarey, CKamoun, A (1988) Antidepressant and anxiolytic activity of tianeptine. An overview of clinical trials. Clin Neuropharmacol suppl 2, S74–S82Google ScholarPubMed
Deptula, DPomara, N (1990) Effects of antidepressants in human performance: a review. J Clin Psychopharmacol 10, 105–111CrossRefGoogle ScholarPubMed
File, SEMabbutt, PS (1991) Effects of tianeptine in animal models of anxiety and on learning and memory. Drug Dev Res 23, 47–56CrossRefGoogle Scholar
Hindmarch, I (1987) Antidepressant drugs and cognitive function.In: Diagnosis and Treatment of Depression – ‘Quo Vadis?’ (Bizière, KGarattini, SSimon, P eds). Symposium, Sanofi Group, May 11-12, 1987, Montpellier, France, 355–363Google Scholar
Hindmarch, IHarrison, CSchillingford, CA (1988) An investigation of the effects of lofepramine, nomifensine, amitriptyline and placebo on aspects of memory and psychomotor performance related to car driving. Int Clin Psychopharmacol 3, 157–165CrossRefGoogle ScholarPubMed
Jaffard, RMocaër, EAlaoui, FBéracochéa, DMarighetto, AToumane, A (1989) Effets de la tianeptine sur l‚apprentissage et la mémoire chez la souris. J Psychiatric Biol Thér n° spécial mars, 37–39Google Scholar
Jaffard, RMocaër, EPoignant, JCMicheau, JMarighetto, AMeunier, MBéracochéa, D (1991) Effects of tianeptine on spontaneous alternation, simple and concurrent spatial discrimination learning and on a sequential alternation deficit induced by long-term ethanol administration in mice. Behav Pharmacol 2, 37–46CrossRefGoogle ScholarPubMed
Judd, LSquire, LRButters, NSalmon, DPPaller, KA (1987) Effects of psychotropic drugs on cognition and memory in normal humans and animals.In: Psychopharmacology the 3rd Generation of Progress (Meltzer, HY eds). 1467–1475Google Scholar
Kato, GWeitsch, AF (1988) Neurochemical profile of tianeptine a new antidepressant drug. Clin Neuropharmacol 11 (Suppl 2), S43–S50Google ScholarPubMed
Lamping, DLSpring, BGelenberg, AJ (1984) Effects of two antidepressants on memory performance in depressed outpatients: a double-blind study. Psychopharmacol 84, 254–261CrossRefGoogle ScholarPubMed
Liljequist, RLinnoila, MMattila, MJ (1974) Effects of two weeks treatment with chlomipramine and nortryptiline alone or in combination with alcohol on learning and memory. Psychopharmacol 39, 181–186CrossRefGoogle ScholarPubMed
Linnoila, MJohnson, JDubyoski, TRoss, RBuchsbaum, MPotter, WZWeingartner, H (1983) Effects of amitriptyline, desipramine and zimeldine alone and in combination with ethanol, in information processing and memory in healthy volunteers. Acta Psychiatr Scand 68 (suppl 308), 175–181CrossRefGoogle Scholar
Mattila, MJLiljequist, RSeppala, T (1978) Effects of amitriptytine and mianserin psychomotor skills on memory in man. Br J Clin Pharmacol 5, 535–555Google Scholar
Mocaër, ERettori, MCKamoun, A (1988) Pharmacological antidepressive effects and tianeptine induced 5-HT uptake increase. Clin Neuropharmacol 11 (suppl 2), S32–S42Google ScholarPubMed
Parrot, ACHindmarch, I (1978) Factor analysis of a sleep evaluation questionnaire. Psychiatr Med 8, 325–329Google Scholar
Peck, AWBye, CEClubley, MHenson, TRiddington, C (1979) A comparison of bupropion hydrochloride with dexamphetamine and amitriptyline in healthy subjects. Br J Clin Pharmacol 7, 469–478CrossRefGoogle ScholarPubMed
Poirier, JLVieillefond, ID (1986) Étude des effets du Clédial sur la performance psychomotrice. Psychol Med 2, 1925–1930Google Scholar
Smith, JMMisiak, H (1976) Critical Flicker Frequency (CFF) and psychotropic drugs in normal human subjets – a review. Psychopharmacol 47, 175–182CrossRefGoogle Scholar
Thompson, PJTrimble, MR (1982) Non MAOI antidepressant drugs and cognitive functions – a review. Psychol Med 12,539–548CrossRefGoogle ScholarPubMed
Von Frenckell, RAnsseau, MDulcire, CWaintraub, L (1990) Effects of tianeptine on vigilance and memory in young healthy volunteers. Psychiatr & Psychobiol 5, 375–380Google Scholar
Warot, DDanjou, PLacomblez, LDiquet, BPuech, AJ (1989) Effets de trois doses de maprotiline (25, 50 et 75 mg) sur la vigilance et la mémoire chez le volontaire sain. Thérapie 44, 257–256Google Scholar
Wolkowitz, OMTinklenberg, JRWeingartner, H (1985) A Psychopharmacological Perspective of Cognitive Functions. Part I Neuropsychobiology 14, 88–96. Part II Neuropsychobiology 14, 133–156CrossRefGoogle Scholar
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