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Effects of long-term therapy with quetiapine and olanzapine on parameters of immunity and cytokine levels in patients with schizophrenia

Published online by Cambridge University Press:  13 August 2021

O. Lobacheva ,
V. Nikitina ,
E. Kornetova ,
S. Vladimirova  and
A. Semke
O. Lobacheva*
Affiliation:
Laboratory Of Clinical Psychoneuroimmunology And Neurobiology, Tomsk National Research Medical Center, Tomsk, Russian Federation
V. Nikitina
Affiliation:
Laboratory Of Clinical Psychoneuroimmunology And Neurobiology, Tomsk National Research Medical Center, Tomsk, Russian Federation
E. Kornetova
Affiliation:
Department Of Endogenous Disorders, Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation
S. Vladimirova
Affiliation:
Department Of Coordination Of Research, Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation
A. Semke
Affiliation:
Department Of Endogenous Disorders, Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

The study of effects of long-term antipsychotic therapy in patients with schizophrenia is relevant.

Objectives

To study effects of long-term antipsychotic therapy on parameters of immunity and cytokine levels in patients with schizophrenia.

Methods

We examined 20 schizophrenic patients, who received quetiapine (group 1) and 17 - olanzapine (group 2) for more than 6 months before admission in the hospital as the main anti-recurrence therapy. Persons aged 20-63 years with length of the follow-up of the disease ≥1 year were included. The investigations included: phenotyping of immunocompetent cells into CD differentiation clusters by flow cytometry; mitogen-induced, spontaneous production of cytokines (IL2, IFN-γ, IL-4, TNF-α) were identified with use of kits for enzyme-linked immunosorbent assay (ELISA).

Results

It was shown that patients of group 1 in comparison with group 2 were characterized by lower values of СD3- lymphocytes (p=0.049), higher values of the spontaneous production of IFN-γ (p=0.01), mitogen-induced production of IL-2 (p=0.043) and IL-4 (p=0.059). In all examined low level of mitogen-induced of IFN-γ (p=0.0001) and TNFα (p=0.002; p=0.0001), high level of spontaneous production of TNFα (p=0.001) were revealed in relation to control.

Conclusions

It was found that the acute period of schizophrenia after prolonged treatment with atypical antipsychotics is accompanied by immunological imbalance and dysregulation of the cytokine system. More severe immune disorders when hospitalized during the exacerbation period were revealed in patients who had been receiving antipsychotic therapy with the atypical antipsychotic quetiapine for a long time. This can be associated with the features of the mechanism of action of atypical antipsychotics.

Disclosure

No significant relationships.

Keywords

PsychoneuroimmunologyschizophréniaAntipsychotics
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S765
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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