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The effects of antidepressant treatment on sleep disturbances in depression

Published online by Cambridge University Press:  16 April 2020

M Kerkhofs  and
J Mendlewicz
M Kerkhofs
Affiliation:
Sleep laboratory, Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Route de Lennik 808, 1070Brussels, Belgium
J Mendlewicz
Affiliation:
Sleep laboratory, Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Route de Lennik 808, 1070Brussels, Belgium
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Summary

Sleep problems are classical complaints in depressed patients. Polygraphie recordings performed in drug free depressed patients during an acute episode of the illness have allowed description of sleep continuity, architecture and REM sleep disturbances. While the specificity of these abnormalities is not fully established, these perturbations appear to be core symptoms of the depressive episode. Antidepressants drugs, whatever their pharmacological profile have been shown to suppress or at least to reduce REM sleep. However, the effects of these drugs on sleep continuity and architecture seem to be related to their specific pharmacological action.

Keywords

REM sleepnon-REM sleeptricyclicsMAOIsSSRIs
Type
Original article
Information
European Psychiatry , Volume 10 , Issue 8 , 1995 , pp. 391 - 396
Copyright
Copyright © Elsevier, Paris 1995

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