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The effectiveness of electroconvulsive therapy in substance use disorder at pharmacological treatment failure major depression

Published online by Cambridge University Press:  19 July 2023

P. Dannon
P. Dannon*
Affiliation:
psychiarty, Hebrew university, jerusalem, Israel

Abstract

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Introduction

Treatment resistant depression (TRD) is common with substance use disorder (SUD) and few studies demonstrated the effectiveness of medication-psychotherapy treatments in this population

Objectives

To compare the effeictiveness of ECT in the treatment resistant depression patients vs TRD with SUD patients.

Methods

14 TRD patients with 14 TRD-SUD patients compared in terms of ECT treatment response rates at baseline, thhree months and six months of the follow up periond. Pateints completed Hamilton anxiety, Hamilton depression-21 items, Barrat 11 impulsivity and visual analog scales each follow up visit.

Results

Both groups completed ECT treatment between 2011-2018 with follow up of 12.3+4.1 months following the ECT procedure. Patients received average 11.7+2.6 bilateral ECT treatments per series. Both groups responded well to ECT treatment in terms of response rates and side effects however there were higher rates of relapse at intermediate to long term follow up period at TRD-SUD group.

Conclusions

ECT seems to be an effective treatment for patiens of TRD-SUD. Moreover the response rates are equal to treatment reisstant depression cases without substance use disorder.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S566 - S567
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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