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Effect of psychotherapy on peripheral BDNF concentration levels in patients with bipolar disorder. A systematic review

Published online by Cambridge University Press:  19 July 2023

M. Valtueña García ,
L. Rubio Rodríguez ,
L. Sánchez-Pastor ,
I. Martínez-Gras  and
R. Rodríguez-Jiménez
M. Valtueña García*
Affiliation:
Psiquiatria, Instituto de Investigación Sanitaria Hospital Universitario 12 de Octubre (imas12), Madrid
L. Rubio Rodríguez
Affiliation:
Psiquiatria, (3) Unidad de Hospitalización psiquiátrica. Fundación Hospital de Jove. Gijón, Spain
L. Sánchez-Pastor
Affiliation:
Psiquiatria, Instituto de Investigación Sanitaria Hospital Universitario 12 de Octubre (imas12), Madrid
I. Martínez-Gras
Affiliation:
Psiquiatria, Instituto de Investigación Sanitaria Hospital Universitario 12 de Octubre (imas12), Madrid
R. Rodríguez-Jiménez
Affiliation:
Psiquiatria, Instituto de Investigación Sanitaria Hospital Universitario 12 de Octubre (imas12), Madrid
*
*Corresponding author.

Abstract

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Introduction

Psychotherapy is a treatment of proven efficacy in bipolar disorder (BD), but little is known about the molecular and cellular mechanisms that it produces in the brain. Brain-derived neurotrophic factor (BDNF) is thought to be important in neuroplasticity and could be increased by psychopharmaceuticals and psychotherapy in BD patients, but evidence in the literature is limited.

Objectives

To analyze the scientific studies that relate psychotherapies with the increase in BNDF levels in patients with BD.

Methods

Systematic review with PRISMA recommendations in PUBMED and Web of Science in July 2022. The search was performed using the combination of keywords “bipolar disorder” AND (“BDNF” OR “Brain Derived Neurotrophic Factor”) AND “psychotherapy”.

Results

With the initial search, 839 studies were obtained, finally 8 articles were analyzed. The available literature supports the role of psychotherapy in increasing BNDF in patients with BD.

Conclusions

BDNF could be a biomarker of therapeutic efficacy in BD. Psychotherapy increases BDNF levels. No differences were found between the different types of psychotherapies. More studies are needed to determine the mechanisms by which psychotherapies produce molecular changes in the brain.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S706
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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