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Effect of BMI on Resting-state Functional Architecture of the Brain in Healthy Individuals and Patients with Psychosis

Published online by Cambridge University Press:  23 March 2020

S. Frangou ,
N. Micali ,
R. Natalie ,
D. Gaelle  and
M. Bruce
S. Frangou
Affiliation:
New York, USA
N. Micali
Affiliation:
Icahn School of Medicine at Mount Sinai, Psychiatry, New York, USA
R. Natalie
Affiliation:
Stanford University, Psychiatry, Palo, Alto, USA
D. Gaelle
Affiliation:
Icahn School of Medicine at Mount Sinai, Psychiatry, New York, USA
M. Bruce
Affiliation:
Rockefeller University, Neuroscience, New York, USA

Abstract

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Elevated body mass index (BMI) is associated with increased multi-morbidity and mortality. The investigation of the relationship between BMI and brain organization has the potential to provide new insights relevant to clinical and policy strategies for weight control. Here, we quantified the effect of BMI on the functional connectivity of the Default-Mode (DMN), Central Executive (CEN), Sensorimotor (SMN) and Visual (VN) networks in 496 healthy individuals that were studied as part of the Human Connectome Project. We found that elevated BMI was associated with disrupted functional integration of sensory-guided (SMN, VN) with internally controlled (DMN, CEN) networks, implicating increased attention to sensory stimuli as a possible mechanism underpinning overeating and weight gain. Our results suggest that weight control strategies should expand to include wider societal policies that incorporate modifications to eating environments and to the visual presentation and branding of food products.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
Workshop: Allostasis insulin and the brain: Implications for the disease modeling and treatment in psychiatry
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S62
Copyright
Copyright © European Psychiatric Association 2017
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