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Economic Aspects in the Treatment of Schizophrenia in Italy: Cost Consequences of an Early Long-acting Injectable Anti-Psychotics (lais) Approach

Published online by Cambridge University Press:  23 March 2020

A. Marcellusi ,
F.S. Mennini ,
R. Brugnoli ,
C. Rapinesi ,
G.D. Kotzalidis ,
S. De Filippis ,
D. Carrus ,
A. Ballerini ,
A. Francomano  and
G. Ducci
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A. Marcellusi
Affiliation:
Universita degli studi Tor Vergata, Ceis EEHTA, Roma, Italy Consiglio Nazionale delle Ricerche CNR, Istituto di Ricerche sulla Popolazione e le Politiche Sociali IRPPS, Roma, Italy
F.S. Mennini
Affiliation:
Universita degli studi Tor Vergata, Ceis EEHTA, Roma, Italy
R. Brugnoli
Affiliation:
Universita La Sapienza, NESMOS Department Neurosciences, Mental Health, and Sensory Organs, Roma, Italy
C. Rapinesi
Affiliation:
Universita La Sapienza, NESMOS Department Neurosciences, Mental Health, and Sensory Organs, Roma, Italy
G.D. Kotzalidis
Affiliation:
Universita La Sapienza, NESMOS Department Neurosciences, Mental Health, and Sensory Organs, Roma, Italy
S. De Filippis
Affiliation:
Universita La Sapienza, NESMOS Department Neurosciences, Mental Health, and Sensory Organs, Roma, Italy Clinic and Hospital, Villa von Siebenthal Neuropsychiatric, Roma, Italy
D. Carrus
Affiliation:
Universita La Sapienza, NESMOS Department Neurosciences, Mental Health, and Sensory Organs, Roma, Italy ASL, VT, Viterbo, Italy
A. Ballerini
Affiliation:
University of Florence, Department of Neuroscience, Psychology, Drug Research and Child Health, Firenze, Italy
A. Francomano
Affiliation:
University of Palermo, Department of Experimental Biomedicine and Clinical Neuroscience, Palermo, Italy
G. Ducci
Affiliation:
DSMASL, Roma1, Roma, Italy
A. Del Casale
Affiliation:
Fondazione P. Alberto Mileno Onlus, Department of Psychiatric Rehabilitation, Vasto, Italy
P. Girardi
Affiliation:
Universita La Sapienza, NESMOS Department Neurosciences, Mental Health, and Sensory Organs, Roma, Italy

Abstract

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Purpose

The aim of this analysis was to evaluate the economic consequences of a new treatment approach in the treatment of schizophrenia in the Italian setting. In terms of direct costs, in Italy was estimated that the main driver were represented by hospitalization and residential cost (71% of total direct cost per patient), followed by semi-residential services (13%), anti-psychotic and other drugs (8%) and ambulatory services (8).

Methods

A probabilistic cost consequence model was developed to estimate the potential cost reductions derived from an early treatment with atypical long-acting injectable anti-psychotics (aLAIs) drugs. A systematic literature review was carried out to identify direct and indirect costs associated to the management of schizophrenic patients in Italy. The model projects a scenario analysis in order to estimate potential cost reductions applying a new model management (MoMa) based on patient recovery and early aLAIs treatment.

Results

Overall, the total economic burden associated with schizophrenia was estimated at €2.7 billion per year. A total of 50.5% of the economic burden was related to indirect costs and 49.5% to direct costs. Drug costs correspond to 10% of the total expenditure in terms of direct costs, while hospitalization and residential costs accounts for 81%. Scenario analysis demonstrate a potential cost reduction between 200 million and 300 million based on the effects of MoMa over the reduction of hospitalization and residential costs.

Conclusions

This analysis was the first attempt to translate clinical management aspects in economic consequences and will be a useful instruments for decision maker.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Walk: Schizophrenia and other psychotic disorders - Part 3
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S272
Copyright
Copyright © European Psychiatric Association 2017
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