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Dysthymia and depressive disorders: dopamine hypothesis

Published online by Cambridge University Press:  16 April 2020

GL Gessa
GL Gessa*
Affiliation:
Department of Neuroscience, “Bernard B Brodie”, University of Cagliari, via Porcell 4, 09124Milan. Italy
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Summary

This paper reviews the recent literature supporting the hypothesis that reduced neurotransmission in the mesolimbic dopamine (DA) system may sustain some of the symptoms of depressive conditions including dysthymia. Experimental evidences indicate that mesolimbic DA plays a crucial role in controlling incentive, motivation and reward. Additionally, in different models of depression, a reduced DA activity in the limbic system, reversed by chronic antidepressant treatment, is observed. Finally, different antidepressants, irrespective of their acute action on the uptake of norepinephrine or serotonin, have the common property when given chronically to potentiate behavioural responses to DA agonists. The DA hypothesis of depression offers an explanation for the antidepressive effect of drugs such as sulpiride and amisulpride given at low doses, that preferentially block DA autoreceptors and thereby increase DA output.

Keywords

dopaminedysthymiadepressionanimal modelsantidepressants
Type
Research Article
Information
European Psychiatry , Volume 11 , Issue S3 , 1996 , pp. 123s - 127s
Copyright
Copyright © Elsevier paris 1996

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References

Acquas, ECarboni, EDi Chiara, GProfound depression of mesolimbic dopamine release after morphine withdrawal in dependent rats. Eur J Pharmacol 1991; 193:133–410.1016/0014-2999(91)90214-BCrossRefGoogle ScholarPubMed
Acquas, EDi Chiara, GDepression of mesolimbic dopamine transmission and sensitization to morphine during opiate abstinence. J Neurochem 1992; 58:1620–4CrossRefGoogle ScholarPubMed
Agmo, AFernandez, HDopamine and sexual behavior in the male rat: a revaluation. J Neural Transm 1989; 77:21–37CrossRefGoogle Scholar
Agmo, ABerenfeld, RReinforcing properties of ejaculation in the male rat: role of opioids and dopamine. Behav Neurosci 1990; 104:177–8210.1037/0735-7044.104.1.177CrossRefGoogle ScholarPubMed
Blackburn, JRPfaus, JGPhillips, AGDopamine functions in appettitive and defensive behaviours. Prog Neurobiol 1992; 39:247–79CrossRefGoogle ScholarPubMed
Bocchetta, ABemardi, FBurrai, CPedditzi, MDel Zompo, MAdoubleblind study of L-sulpiride versus amitriptyline in lithium-maintained bipolar depressives. Acta Psychiatr Scand 1993; 88:434–910.1111/j.1600-0447.1993.tb03487.xCrossRefGoogle Scholar
Costa e Silva, JATraitement des dysthymies par de faibles doses d’amisulpride. Ann Psychiatry 1990; 5:242–9Google Scholar
Damsma, GPfaus, JGWenkstern, DPhillips, AGFibiger, HCSexual behavior increases dopamine transmission in the nucleus accumbens and striatum of male rats: comparison with novelty and locomotion. Behav Neurosci 1992; 106:181–91CrossRefGoogle ScholarPubMed
Del Zompo, MBocchetta, ABernardi, FBurral, CCorsini, GUClinical evidence for a role of dopaminergic system in depressive syndromes. Adv Biosci 1990; 77:177–84Google Scholar
Di Chiara, GImperato, ADrugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 1988; 85:5274–810.1073/pnas.85.14.5274CrossRefGoogle ScholarPubMed
Fibiger, HCPhillips, AGZis, APDeficits in instrumental responding after 6-hydroxydopamine lesion of the nigro-neostriatal dopaminergic projection. Pharmacol Biochem Behav 1974; 2:87–96CrossRefGoogle Scholar
Fibiger, HCPhillips, AGRole of catecholamine transmitters in reward systems: implications for the neurobiology of affect. In: Oreland, LBrain Reward Systems and Abuse. New York: Press, 1987; 61–74Google Scholar
Fiorino, DFCoury, AFibiger, HCPhillips, AGElectrical stimulation reward sites in the ventral tegmental area increases dopamine transmission in the nucleus accumbens of the rat. Behav Brain Res 1993; 55:131–41CrossRefGoogle ScholarPubMed
Fouriezos, GHansson, PWise, RANeuroleptic-induced attenuation of brain stimulation reward. J comp phisiol Psychol. 1978; 92:659–69Google ScholarPubMed
Frank, RAManderscheid, PZPanicker, SWilliams, EPKokoris, DCocaine euphoria, dysphoria, and tolerance assessed using druginduced changes in brain-stimulation reward. Pharmacol Biochem Behav 1992; 42:771–910.1016/0091-3057(92)90028-ECrossRefGoogle Scholar
Gambarana, CGhiglieri, OTaddei, ITagliamonte, ADe Montis, MGImipramine and fluoxetine prevent the learned helplessness behavior acquisition in rats through a distinct mechanim of action. Behav Pharmacol 1995; 5:66–73Google Scholar
Gawin, FHKleber, HDAbstinence symptomatology and psychiatric diagnosis in chronic cocaine abusers. Arch Gen Psychiatry 1986; 43:108–16CrossRefGoogle Scholar
Hemby, SEMartin, TJCo, CDworkin, SISmith, JEThe effects of intravenous heroin administration on extracellular nucleus accumbens dopamine concentrations as determined by in vivo microdialysis. J Pharmacol Exp Ther 1995; 273:592–8Google ScholarPubMed
Hernandez, LHoebel, BGFood reward and cocaine increase extracellular dopamine in the nucleus accumbens as measures by microdialysis. Life Sci 1988; 42:1705–1210.1016/0024-3205(88)90036-7CrossRefGoogle Scholar
Koob, GFLe, HTCreese, IThe D1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rats. NeurosciLett 1987; 79:315–20Google Scholar
Lyness, WHFriedle, NMMoore, KEDestruction of dopaminergic nerve terminals in the nucleus accumbens: effect on d-amphetamine self-administration. Pharmacol Biochem Behav 1979; 11:553–610.1016/0091-3057(79)90040-6CrossRefGoogle Scholar
Maier, WBenkert, OTreatment of chronic depression with sulpiride: evidence of efficacy in placebo-controlled single case studies. Psychopharmacology 1994; 115:495–50110.1007/BF02245573CrossRefGoogle ScholarPubMed
Markou, AKoob, GFPost cocaine anhedonia: an animal model of cocaine withdrawal. Neuropsychopharmacology 1991; 4:17–26Google Scholar
McCullough, LDSalamone, JDInvolvement of nucleus accumbens dopamine in the motor activity induced by periodic food presentation: a microdialysis and behavioral study. Brain Res 1992; 592:29–36CrossRefGoogle ScholarPubMed
Melis, MRArgiolas, ADopamine and sexual behavior. Neurosci Biobehav Rev 1995; 19:19–38CrossRefGoogle ScholarPubMed
Mucha, RFIs the motivational effect of opiate withdrawal reflected by common somatic indices of precipitated withdrawal? A place conditioning study in the rat. Brain Res 1987; 418:214–20CrossRefGoogle ScholarPubMed
Nomikos, GGDamsma, GWenkstem, DFibiger, HCChronic desipramine enhances amphetamine-induced increases in interstitial concentrations of dopamine in the nucleus accumbens. Eur J Pharmacol 1991; 195:63–73CrossRefGoogle ScholarPubMed
Pettit, HOJustice, JB JrDopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis. Pharmacol Biochem Behav 1989; 34:899–904CrossRefGoogle ScholarPubMed
Pettit, HOJustice, JB JrEffect of dose on cocaine self-administration behavior and dopamine levels in the nucleus accumbens. Brain Res 1991; 539:94–102CrossRefGoogle ScholarPubMed
Pfaus, JGDamsma, GNomikos, GG et al. Sexual behavior enhances central dopamine transmission in the male rat. Brain Res 1990; 530:345–810.1016/0006-8993(90)91309-5CrossRefGoogle ScholarPubMed
Pfaus, JGPhillips, AGRole of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat. I. Effects of systemic administration of dopamine antagonists. Behav Neurosci 1991; 105:727–43CrossRefGoogle Scholar
Pilcher, CWTStolemar, IPConditioned flavor aversion for assessing precipitated morphine abstinence in rats. Pharmacol Biochem Behav 1976; 4:327–34CrossRefGoogle ScholarPubMed
Pleim, ETMatochik, JABarfield, RJAuerbach, SBCorrelation of dopamine release in the nucleus accumbens with masculine sexual behavior in rats. Brain Res 1990; 524:160–3CrossRefGoogle ScholarPubMed
Porsolt, RDBehavioral despair. In: Enna, SJAntidepressant: Neurochemical, Behavioral and Clinical Perspectives. New York: Raven Press, 1981:121–39Google Scholar
Roberts, DCSKoob, GFKlonoff, PFibiger, HCExtinction and recoveri of cocaine self-administration following 6-hydroxydo-pamine lesions of the nucleus accumbens. Pharmacol Biochem Behav 1980; 12:781–7CrossRefGoogle ScholarPubMed
Roberts, DCSKoob, GFDisruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats. Pharmacol Biochem Behav 1982; 17:901–410.1016/0091-3057(82)90469-5CrossRefGoogle ScholarPubMed
Roberts, DCSVickers, GAtypical neuroleptics incease self-administration of cocaine: ann evaluation of a behavioral screen for anti-psychotic activity. Psycopharmacology 1984; 82:135–9CrossRefGoogle Scholar
Robertson, MWLeslie, CABennett, JP JrApparent synaptic dopamine deficiency induced by withdrawal from chronic cocaine treatment. Brain Res 1991; 538:337–9CrossRefGoogle ScholarPubMed
Rossetti, ZLD’Aquila, PSHmaidan, YGessa, GLSerra, GRepeated treatment with Imipramine potentiates cocaine-induced dopamine release and motor stimulation. Eur J Pharmacol 1991; 201:243–510.1016/0014-2999(91)90353-RCrossRefGoogle ScholarPubMed
Rossetti, ZIHmaidan, YGessa, GLMarked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats. Eur J Pharmacol 1992; 221:227–34CrossRefGoogle ScholarPubMed
Rossetti, ZLLai, MHmaidan, YGessa, GLDepletion of mesolimbic dopamine during behavioral despair: partial reversal by chronic imipramine. Eur J Pharmacol 1993; 242:313–5CrossRefGoogle ScholarPubMed
Schildkraut, JJWatson, RKDraskoczy, PR et al. Amphetamine withdrawal: depression and MHPG excretion. Lancet 1971; 2:485–6CrossRefGoogle Scholar
Shaham, YStewart, JExposure to mild stress enhances the reinforcing efficacy of intravenous heroin self-administration in rats. Psychopharmacology 1994; 114:523–7CrossRefGoogle ScholarPubMed
Serra, GCollu, MD’Aquila, PSDe Montis, GMGessa, GLPossible role of dopamine D1 receptor in the behavioral supersensitivity to dopamine agonists induced by chronic treatment with antidepressants. Brain Res 1990; 527:234–4310.1016/0006-8993(90)91142-4CrossRefGoogle ScholarPubMed
Serra, GCollu, MD’Aquila, PSGessa, GLRole of the mesolimbic dopamine system in the mechanism of action of antidepressants. In: Proceedings of XVIIIth CINP Congress Satellite Symposium The Biology and Pharmacology of Manic-Depressive Disordes: From Molecular Theories to Clinical Practice. Copenhagen. Pharmacol Toxicol 1992; 71:72–85Google ScholarPubMed
Watson, RAmphetamine withdrawal: Affective state, sleep patterns and MHGP excretion. Am J Psychiatry 1972; 129:263–910.1176/ajp.129.3.263CrossRefGoogle Scholar
Watson, RBakos, LCompton, PGawin, FCocaine use and withdrawal: the effect on sleep and mood. Am J Drug Alcohol Abuse 1992; 18:21–28CrossRefGoogle Scholar
Weddington, WWHaertzen, CA et al. Changes in mood, craving, and sleep during short-term abstinence reported by male cocaine addicts. A controlled, residential study. Arch Gen Psychiatry 1990; 47:861–8CrossRefGoogle ScholarPubMed
Weiss, FLorang, MTBloom, FEKoob, GFOral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmacol Exp Ther 1993; 267:250–8Google ScholarPubMed
Willner, PDopamine and depression: a review of recent evidence. Brain Res Rev 1983; 13:181–6Google Scholar
Willner, PAnimal models of depression: validity and application. In: Gessa, GLNeurobiology Treatment. New York: Raven Press, 1995:19–41Google Scholar
Wise, RAThe brain and reward. Liebman, JCooper, SJThe neuropharmacological basis of reward. Oxford: Oxford University Press, 1989:377–424Google Scholar
Yokel, RAWise, RAIncreased lever pressing for amphetamine after pimozide in rats: implications for a dopamine theory of reward. Science 1975; 187:547–910.1126/science.1114313CrossRefGoogle Scholar
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