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Dysregulation of the hypothalamic-pituitary-adrenal system in Tuvan alcoholics is associated with a high level of stress in comparison with ethnic Russian patients

Published online by Cambridge University Press:  01 September 2022

T. Shushpanova ,
N. Bokhan ,
A. Mandel  and
T. Novozheeva
T. Shushpanova*
Affiliation:
Mental Health Research Institute of Tomsk National Investigation MedicalCenter of Russian Academy of Sciences, Clinical Psychoneuroimmunology And Neurobiology, Tomsk, Russian Federation
N. Bokhan
Affiliation:
Siberian State Medical University, Department Of Psychiatry, Narcology And Psychotherapy,, Tomsk, Russian Federation Mental Health Research Institute Tomsk National Research Medical Center Russia Academy of Science, , Department Of Addictive States, Tomsk, Russian Federation
A. Mandel
Affiliation:
Mental Health Research Institute Tomsk National Research Medical Center Russia Academy of Science, , Department Of Addictive States, Tomsk, Russian Federation
T. Novozheeva
Affiliation:
Mental Health Research Institute of Tomsk National Investigation MedicalCenter of Russian Academy of Sciences, Clinical Psychoneuroimmunology And Neurobiology, Tomsk, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Alcoholization is considered as prolonged auto-aggression, low frustration tolerance, filling of the existential vacuum. In all cases, the use of a psychoactive substance that alters the state of consciousness is regarded as a way of escape from real life.

Objectives

The study of clinically significant markers in alcoholism associated with the constitutional characteristics of craving for alcohol in people of different ethnicity is importance for the formation of new approaches to prevention and treatment.

Methods

68 Russian alcoholics and 67 Tuvans alcoholics only men and 20 healthy male were monitored. Clinical assessment of the condition of patients was carried out with the traditional clinical description. Enzyme-linked immunosorbent assay kits were used to determine serum hormone levels in patients and volunteers.

Results

Deeper shifts in the increase in ACTH and Cortisol levels were found in alcoholic Tuvinians compared with Russian patients, which is associated with a high risk of alcohol dependence and a highly progressive course of the disease. The index of the ratio Cortisol/ACTH (IR) in the blood of alcoholic patients of the Russian (IR - 10,36) and Tuvan (IR - 10,62) nationalities does not differ, but significantly (1.5 times) differs from the indicator in healthy individuals (IR - 15,12).

Conclusions

The background level of dysregulation of the hypothalamic-pituitary-adrenal axis in patients of Tuvan nationality is significantly more pronounced, however, the index of Cortisol/ACTH ratios (IR) in each ethnic group of patients is constant in this disease, which is characterized by a high level of stress.

Disclosure

No significant relationships.

Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S545
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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