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Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder

Published online by Cambridge University Press:  16 April 2020

Marijn Lijffijt ,
J. Leon Kenemans ,
Annemiek ter Wal ,
Elise H. Quik ,
C. Kemner ,
Herman Westenberg ,
Marinus N. Verbaten  and
Herman van Engeland
Marijn Lijffijt*
Affiliation:
Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584CAUtrecht, The Netherlands
J. Leon Kenemans
Affiliation:
Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584CAUtrecht, The Netherlands Department of Psychonomics, Utrecht University, Utrecht, The Netherlands
Annemiek ter Wal
Affiliation:
Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584CAUtrecht, The Netherlands Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
Elise H. Quik
Affiliation:
Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584CAUtrecht, The Netherlands
C. Kemner
Affiliation:
Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
Herman Westenberg
Affiliation:
Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
Marinus N. Verbaten
Affiliation:
Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584CAUtrecht, The Netherlands
Herman van Engeland
Affiliation:
Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
*
*Corresponding author. Present address: Department of Psychiatry and Behavioral Sciences, The university of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555-0189, USA. Tel.: +1 409 747 9682; fax: +1 409 747 8351. E-mail address: [email protected] (M. Lijffijt).
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Abstract

Purpose

The effect of methylphenidate (MPH) on inhibitory control as assessed by the stop task in children with attention-deficit/hyperactivity disorder (ADHD) could be influenced by task difficulty and may be mediated by attention.

Subjects and methods

Fifteen children with ADHD performed the stop and the change task after placebo, 0.5 and 1.0 mg/kg MPH in a within-subject design.

Results

Linear-trend analysis showed a similar effect of MPH in both tasks and a stronger effect for inhibitory control than for attention. Furthermore, a correlation was found between blood serum metabolites of norepinephrine and dopamine for attentional measures and inhibitory control measures, respectively.

Discussion and conclusion

In children with ADHD MPH could act primarily on inhibitory control, and is not influenced by task difficulty. Also, attention and inhibitory control could have differential pharmacological profiles.

Keywords

Attention-deficit/hyperactivity disorderMethylphenidateStop-signal paradigmInhibitory controlAttentionBlood serum
Type
Short communication
Information
European Psychiatry , Volume 21 , Issue 8 , December 2006 , pp. 544 - 547
Copyright
Copyright © Elsevier Masson SAS 2006

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