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Does the degree of smoking effect the severity of tardive dyskinesia? A longitudinal clinical trial

Published online by Cambridge University Press:  16 April 2020

A. Diehl ,
I. Reinhard ,
A. Schmitt ,
K. Mann  and
W.F. Gattaz
A. Diehl*
Affiliation:
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Square J 5, 68159Mannheim, Germany
I. Reinhard
Affiliation:
Department of Biostatistics, Central Institute of Mental Health, University of Heidelberg, Square J 5, 68159Mannheim, Germany
A. Schmitt
Affiliation:
Department for Psychiatry and Psychotherapy, University of Goettingen, von-Siebold-Str. 5, 37075Goettingen, Germany
K. Mann
Affiliation:
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Square J 5, 68159Mannheim, Germany
W.F. Gattaz
Affiliation:
Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr. Ovidio Pires de Campos 785, 05403-010Sao Paulo, Brazil
*
*Corresponding author. Tel.: +49 621 1703 3542; fax: +49 621 1703 3545. E-mail address: [email protected] (A. Diehl) [email protected] (I. Reinhar), [email protected] (A. Schmitt), [email protected] (K. Mann), [email protected] (W. F. Gattaz).
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Abstract

Background

Tardive dyskinesia (TD) is a movement disorder observed after chronic neuroleptic treatment. Smoking is presumed to increase the prevalence of TD. The question of a cause-effect-relationship between smoking and TD, however, remains to be answered. Purpose of this study was to examine the correlation between the degree of smoking and the severity of TD with respect to differences caused by medication.

Method

We examined 60 patients suffering from schizophrenia and TD. We compared a clozapine-treated group with a group treated with typical neuroleptics. Movement disorders were assessed using the Abnormal-Involuntary-Movement-Scale and the technical device digital image processing, providing rater independent information on perioral movements.

Results

We found a strong correlation (.80 < r < .90, always p < .0001) between the degree of smoking and severity of TD. Repeated measurements revealed a positive correlation between changes in cigarette consumption and changes of the severity of TD (p < .0001). Analyses of covariance indicated a significant group-effect with a lower severity of TD in the clozapine-group compared to the typical-neuroleptics-group (p = .010). Interaction-analyses indicated a higher impact of smoking on the severity of TD in the typical-neuroleptics-group compared to the clozapine-group (p = .033).

Conclusion

Concerning a possible cause-effect-relationship between smoking and TD, smoking is more of a general health hazard than neuroleptic exposure in terms of TD.

Keywords

Tardive dyskinesiaMovement disorderSmokingNicotineSchizophreniaAntipsychotics
Type
Original article
Information
European Psychiatry , Volume 24 , Issue 1 , 2009 , pp. 33 - 40
Copyright
Copyright © Elsevier Masson SAS 2009

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References

American Psychiatric Association Practice guidelines for the treatment of patients with schizophrenia WashingtonAmerican Psychiatric Press 1997Google Scholar
Andersson, K., Fuxe, K., Agnati, L.F.Effects of single injections of nicotine on the ascending dopamine pathways in the rat. Evidence for increases of dopamine turnover in the mesostriatal and mesolimbic dopamine neurons. Acta Physiol Scand 1981;112(3):345–347CrossRefGoogle ScholarPubMed
Baca-Garcia, E., Stanilla, J.K., Buchel, C., Gattaz, W.F., de Leon, J.Diurnal variability of orofacial dyskinetic movements. Pharmacopsychiatry 1999;32(2):73–75CrossRefGoogle ScholarPubMed
Bartzokis, G., Wirshing, W.C., Hill, M.A., Cummings, J.L., Altshuler, L., May, P.R.Comparison of electromechanical measures and observer ratings of tardive dyskinesia. Psychiatry Res 1989;27(2):193–198CrossRefGoogle ScholarPubMed
Bergen, J., Kitchin, R., Berry, G.Predictors of the course of tardive dyskinesia in patients receiving neuroleptics. Biol Psychiatry 1992;32(7):580–594CrossRefGoogle ScholarPubMed
Binder, R.L., Kazamatsuri, H., Nishimura, T., McNiel, D.E.Smoking and tardive dyskinesia. Biol Psychiatry 1987;22(10):1280–1282CrossRefGoogle ScholarPubMed
Büchel, C., de Leon, J., Simpson, G.M., Gattaz, W.F.Oral tardive dyskinesia: validation of a measuring device using digital image processing. Psychopharmacology (Berl) 1995;117(2):162–165CrossRefGoogle ScholarPubMed
Cadet, J.L., Lohr, J.B., Jeste, D.V.Free radicals and tardive dyskinesia. Trends Neurosci 1986;9:107–108CrossRefGoogle Scholar
Casey, D.E.Tardive dyskinesiaMeltzer, H.Y.Psychopharmacology: the third generation of progress New YorkRaven Press 1987 1411–1419Google Scholar
Chong, S.A., Choo, H.L.Smoking among Chinese patients with schizophrenia. Aust N Z J Psychiatry 1996;30(3):350–353CrossRefGoogle ScholarPubMed
Chong, S.A., Sachdev, P., Mahendran, R., Chua, H.C.Neuroleptic and anticholinergic drug use in Chinese patients with schizophrenia resident in a state psychiatric hospital in Singapore. Aust N Z J Psychiatry 2000;34(6):988–991CrossRefGoogle Scholar
Chong, S.A., Tan, E.C., Tan, C.H.Mythily. Smoking and tardive dyskinesia: lack of involvement of the CYP1A2 gene. J Psychiatry Neurosci 2003;28(3):185–189Google ScholarPubMed
Church, D.F., Pryor, W.A.Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985;64:111–126CrossRefGoogle ScholarPubMed
Correll, C.U., Leucht, S., Kane, J.M.Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies. Am J Psychiatry 2004;161(3):414–425CrossRefGoogle ScholarPubMed
Davis, J.M.Comparative doses and costs of antipsychotic medication. Arch Gen Psychiatry 1976;33(7):858–861CrossRefGoogle ScholarPubMed
de Beaurepaire, R., Lukasiewicz, M., Beauverie, P., Castera, S., Dagorne, O., Espaze, R.et al.Comparison of self-reports and biological measures for alcohol, tobacco, and illicit drugs consumption in psychiatric inpatients. Eur Psychiatry 2007;22(8):540–548CrossRefGoogle ScholarPubMed
Dean, C.E., Kuskowski, M.A., Caligiuri, M.P.Predictors of neuroleptic-induced dyskinesia and parkinsonism: the influence of measurement methods and definitions. J Clin Psychopharmacol 2006;26(6):560–565CrossRefGoogle ScholarPubMed
Desai, H.D., Seabolt, J., Jann, M.W.Smoking in patients receiving psychotropic medications: a pharmacokinetic perspective. CNS Drugs 2001;15(6):469–494CrossRefGoogle ScholarPubMed
Diehl, A., Braus, D.F., Buchel, C., Krumm, B., Medori, R., Gattaz, W.F.[Tardive dyskinesia: pergolid, a possible therapeutic option]. Psychiatr Prax 2003;30(6):333–337Google Scholar
Dilsaver, S.C., Smeltzer, D.J.Smoking and tardive dyskinesia. Biol Psychiatry 1988;24(3):364CrossRefGoogle ScholarPubMed
Dixon, L., Weiden, P.J., Haas, G., Sweeney, J., Frances, A.J.Increased tardive dyskinesia in alcohol-abusing schizophrenic patients. Compr Psychiatry 1992;33(2):121–122CrossRefGoogle ScholarPubMed
Dolder, C.R., Jeste, D.V.Incidence of tardive dyskinesia with typical versus atypical antipsychotics in very high risk patients. Biol Psychiatry 2003;53(12):1142–1145CrossRefGoogle ScholarPubMed
Ellingrod, V.L., Schultz, S.K., Arndt, S.Abnormal movements and tardive dyskinesia in smokers and nonsmokers with schizophrenia genotyped for cytochrome P450 2D6. Pharmacotherapy 2002;22(11):1416–1419CrossRefGoogle ScholarPubMed
Ganzini, L., Heintz, R.T., Hoffman, W.F., Casey, D.E.The prevalence of tardive dyskinesia in neuroleptic-treated diabetics. A controlled study. Arch Gen Psychiatry 1991;48(3):259–263CrossRefGoogle ScholarPubMed
Gattaz, W.F., Buchel, C.Assessment of tardive dyskinesia by means of digital image processing. Psychopharmacology (Berl) 1993;111(3):278–284CrossRefGoogle ScholarPubMed
Glazer, W.M., Morgenstern, H., Niedzwiecki, D., Hughes, J.Heterogeneity of tardive dyskinesia. A multivariate analysis. Br J Psychiatry 1988;152:253–259CrossRefGoogle ScholarPubMed
Goff, D.C., Henderson, D.C., Amico, E.Cigarette smoking in schizophrenia: relationship to psychopathology and medication side effects. Am J Psychiatry 1992;149(9):1189–1194Google ScholarPubMed
Guy, W.Clinical Global ImpressionsECDEU assessment manual for psychopharmacology WashingtonUS Dapartment of Health, Education and Welfare 1976 p. 534–7Google Scholar
Harris, J.G., Kongs, S., Allensworth, D., Martin, L., Tregellas, J., Sullivan, B.et al.Effects of nicotine on cognitive deficits in schizophrenia. Neuropsychopharmacology 2004;29(7):1378–1385CrossRefGoogle Scholar
Hughes, J.R., Hatsukami, D.K., Mitchell, J.E., Dahlgren, L.A.Prevalence of smoking among psychiatric outpatients. Am J Psychiatry 1986;143(8):993–997Google ScholarPubMed
Iager, A.C., Kirch, D.G., Wyatt, R.J.A Negative Symptom Rating Scale. Psychiatry Res 1985;16(1):27–36CrossRefGoogle ScholarPubMed
Jacobsen, L.K., D’Souza, D.C., Mencl, W.E., Pugh, K.R., Skudlarski, P., Krystal, J.H.Nicotine effects on brain function and functional connectivity in schizophrenia. Biol Psychiatry 2004;55(8):850–858CrossRefGoogle Scholar
Jann, M.W., Saklad, S.R., Ereshefsky, L., Richards, A.L., Harrington, C.A., Davis, C.M.Effects of smoking on haloperidol and reduced haloperidol plasma concentrations and haloperidol clearance. Psychopharmacology (Berl) 1986;90(4):468–470CrossRefGoogle ScholarPubMed
Jeste, D.V., Wyatt, R.J.Therapeutic strategies against tardive dyskinesia. Two decades of experience. Arch Gen Psychiatry 1982;39(7):803–816CrossRefGoogle Scholar
Kane, J.M., Aguglia, E., Altamura, A.C., Ayuso Gutierrez, J.L., Brunello, N., Fleischhacker, W.W.et al.Guidelines for depot antipsychotic treatment in schizophrenia. European Neuropsychopharmacology Consensus Conference in Siena, Italy. Eur Neuropsychopharmacol 1998;8(1):55–66CrossRefGoogle ScholarPubMed
Kane, J.M., Smith, J.M.Tardive dyskinesia: prevalence and risk factors, 1959 to 1979. Arch Gen Psychiatry 1982;39(4):473–481CrossRefGoogle ScholarPubMed
Kane, J.M., Weinhold, P., Kinon, B., Wegner, J., Leader, M.Prevalence of abnormal involuntary movements (“spontaneous dyskinesias”) in the normal elderly. Psychopharmacology (Berl) 1982;77(2):105–108CrossRefGoogle ScholarPubMed
Kirch, D.G., Alho, A.M., Wyatt, R.J.Hypothesis: a nicotine-dopamine interaction linking smoking with Parkinson’s disease and tardive dyskinesia. Cell Mol Neurobiol 1988;8(3):285–291CrossRefGoogle ScholarPubMed
Leonard, S., Adler, L.E., Benhammou, K., Berger, R., Breese, C.R., Drebing, C.et al.Smoking and mental illness. Pharmacol Biochem Behav 2001;70(4):561–570CrossRefGoogle ScholarPubMed
Lohr, J.B., Cadet, J.L., Lohr, M.A., Larson, L., Wasli, E., Wade, L.et al.Vitamin E in the treatment of tardive dyskinesia: the possible involvement of free radical mechanisms. Schizophr Bull 1988;14(2):291–296CrossRefGoogle ScholarPubMed
Masterson, E., O’Shea, B.Smoking and malignancy in schizophrenia. Br J Psychiatry 1984;145:429–432CrossRefGoogle Scholar
May, P.R., Lee, M.A., Bacon, R.C.Quantitative assessment of neuroleptic-induced extrapyramidal symptoms: clinical and nonclinical approaches. Clin Neuropharmacol 1983;6(Suppl 1):S35–S51CrossRefGoogle ScholarPubMed
Menza, M.A., Grossman, N., Van Horn, M., Cody, R., Forman, N.Smoking and movement disorders in psychiatric patients. Biol Psychiatry 1991;30(2):109–115CrossRefGoogle ScholarPubMed
Meyer, J.M.Individual changes in clozapine levels after smoking cessation: results and a predictive model. J Clin Psychopharmacol 2001;21(6):569–574CrossRefGoogle ScholarPubMed
Mukherjee, S., Wisniewski, A., Bilder, R., Sackeim, H.A.Possible association between tardive dyskinesia and altered carbohydrate metabolism. Arch Gen Psychiatry 1985;42(2):205CrossRefGoogle ScholarPubMed
Naber, D., Leppig, M., Grohmann, R., Hippius, H.Efficacy and adverse effects of clozapine in the treatment of schizophrenia and tardive dyskinesia—a retrospective study of 387 patients. Psychopharmacology (Berl) 1989;99(Suppl):S73–S76CrossRefGoogle Scholar
Nilsson, A., Waller, L., Rosengren, A., Adlerberth, A., Wilhelmsen, L.Cigarette smoking is associated with abnormal involuntary movements in the general male population—a study of men born in 1933. Biol Psychiatry 1997;41(6):717–723CrossRefGoogle ScholarPubMed
Overall, J.E., Gorham, D.R.The Brief Psychiatric Rating Scale. Psychol Res 1962;10:799–812Google Scholar
Pall, H.S., Williams, A.C., Blake, D.R., Lunec, J.Evidence of enhanced lipid peroxidation in the cerebrospinal fluid of patients taking phenothiazines. Lancet 1987;2(8559):596–599CrossRefGoogle ScholarPubMed
Patterson, B.D., Swingler, D., Willows, S.Prevalence of and risk factors for tardive dyskinesia in a Xhosa population in the Eastern Cape of South Africa. Schizophr Res 2005;76(1):89–97CrossRefGoogle Scholar
Peacock, L., Solgaard, T., Lublin, H., Gerlach, J.Clozapine versus typical antipsychotics. A retro- and prospective study of extrapyramidal side effects. Psychopharmacology (Berl) 1996;124(1-2):188–196CrossRefGoogle ScholarPubMed
Richardson, M.A., Craig, T.J., Branchey, M.H.Intra-patient variability in the measurement of tardive dyskinesia. Psychopharmacology (Berl) 1982;76(3):269–272CrossRefGoogle ScholarPubMed
Rosengarten, H., Schweitzer, J.W., Friedhoff, A.J.Possible genetic factors underlying the pathophysiology of tardive dyskinesia. Pharmacol Biochem Behav 1994;49(3):663–667CrossRefGoogle ScholarPubMed
Rostami-Hodjegan, A., Amin, A.M., Spencer, E.P., Lennard, M.S., Tucker, G.T., Flanagan, R.J.Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine dose adjustment and to assess compliance in individual patients. J Clin Psychopharmacol 2004;24(1):70–78CrossRefGoogle ScholarPubMed
Salokangas, R.K., Honkonen, T., Stengard, E., Koivisto, A.M., Hietala, J.Cigarette smoking in long-term schizophrenia. Eur Psychiatry 2006;21(4):219–223CrossRefGoogle ScholarPubMed
Schooler, N.R., Kane, J.M.Research diagnoses for tardive dyskinesia. Arch Gen Psychiatry 1982;39(4):486–487Google ScholarPubMed
Shiffman, S.M., Gritz, E.R., Maltese, J., Lee, M.A., Schneider, N.G., Jarvik, M.E.Effects of cigarette smoking and oral nicotine on hand tremor. Clin Pharmacol Ther 1983;33(6):800–805CrossRefGoogle ScholarPubMed
Simpson, G.M.The treatment of tardive dyskinesia and tardive dystonia. J Clin Psychiatry 2000;61(Suppl 4):39–44Google ScholarPubMed
Smith, J.M., Baldessarini, R.J.Changes in prevalence, severity, and recovery in tardive dyskinesia with age. Arch Gen Psychiatry 1980;37(12):1368–1373CrossRefGoogle ScholarPubMed
Soares-Weiser, K., Fernandez, H.H.Tardive dyskinesia. Semin Neurol 2007;27(2):159–169CrossRefGoogle ScholarPubMed
Soares-Weiser, K., Rathbone, J. Neuroleptic reduction and/or cessation and neuroleptics as specific treatments for tardive dyskinesia. Cochrane Database Syst Rev 2006 (1): CD000459CrossRefGoogle Scholar
Stanilla, J.K., Buchel, C., Alarcon, J., de Leon, J., Simpson, G.M.Diurnal and weekly variation of tardive dyskinesia measured by digital image processing. Psychopharmacology (Berl) 1996;124(4):373–376CrossRefGoogle ScholarPubMed
Strand, J.E., Nyback, H.Tobacco use in schizophrenia: a study of cotinine concentrations in the saliva of patients and controls. Eur Psychiatry 2005;20(1):50–54CrossRefGoogle ScholarPubMed
Tiwari, A.K., Deshpande, S.N., Rao, A.R., Bhatia, T., Mukit, S.R., Shriharsh, V.et al.Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: I. Association of CYP1A2 gene polymorphism. Pharmacogenomics J 2005;5(1):60–69CrossRefGoogle ScholarPubMed
Vinarova, E., Vinar, O., Kalvach, Z.Smokers need higher doses of neuroleptic drugs. Biol Psychiatry 1984;19(8):1265–1268Google ScholarPubMed
Waddington, J.L.Schizophrenia, affective psychoses, and other disorders treated with neuroleptic drugs: the enigma of tardive dyskinesia, its neurobiological determinants, and the conflict of paradigms San DiegoAcademic Press 1989 p. 297-353Google ScholarPubMed
Yassa, R., Lal, S., Korpassy, A., Ally, J.Nicotine exposure and tardive dyskinesia. Biol Psychiatry 1987;22(1):67–72CrossRefGoogle ScholarPubMed
Yassa, R., Nair, V., Schwartz, G.Tardive dyskinesia and the primary psychiatric diagnosis. Psychosomatics 1984;25(2):135–138CrossRefGoogle ScholarPubMed
Zhang, X.Y., Tan, Y.L., Zhou, D.F., Cao, L.Y., Wu, G.Y., Haile, C.N.et al.Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenic patients with tardive dyskinesia. J Clin Psychiatry 2007;68(5):754–760CrossRefGoogle ScholarPubMed
Ziedonis, D.M., Kosten, T.R., Glazer, W.M., Frances, R.J.Nicotine dependence and schizophrenia. Hosp Community Psychiatry 1994;45(3):204–206Google Scholar
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