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Does maternal age or related factors influence the appearance of psychopathology in children?

Published online by Cambridge University Press:  13 August 2021

J. Buesa Lorenzo ,
A. García-Blanco ,
A. Moreno-Giménez ,
L. Campos Berga ,
R. Sahuquillo-Leal ,
A. Nowak ,
D. Hervás ,
V. Diago  and
M. Vento
J. Buesa Lorenzo*
Affiliation:
Psychiatry, University and Polytechnic Hospital La Fe, Valencia, Spain
A. García-Blanco
Affiliation:
Neonatal Research Group, The Medical Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain
A. Moreno-Giménez
Affiliation:
Neonatal Research Group, The Medical Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain
L. Campos Berga
Affiliation:
Psychiatry, University and Polytechnic Hospital La Fe, Valencia, Spain
R. Sahuquillo-Leal
Affiliation:
Neonatal Research Group, The Medical Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain
A. Nowak
Affiliation:
Psychiatry, Adam Mickiewicz University, Poznań, Poland
D. Hervás
Affiliation:
Data Science Unit, Biostatistics, And Bioinformatics, The Medical Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain
V. Diago
Affiliation:
Gynaecology And Obstetrics, University and Polytechnic Hospital La Fe, Valencia, Spain
M. Vento
Affiliation:
Neonatal Research Group, The Medical Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain
*
*Corresponding author.

Abstract

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Introduction

Maternal age and related factors, such as social vulnerability, are associated with neurodevelopmental and behavioral disorders in offspring.

Objectives

To examine the influence of maternal age and its related factors on the appearance of autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), alterations in executive functions and behavioral syndromes of the offspring.

Methods

A prospective study was conducted, consisting of 131 healthy pregnant women aged 20 to 41 years, recruited at 38 weeks’ gestation. Their offspring were followed up to 2 years after birth, when psychopatology was assessed. Maternal age and possible related factors were considered predictors. Bayesian ordinal regression models were performed for each outcome variable.

Results

Symptoms of ASD in children were associated with an older maternal age (OR = 0.188; 95% CI[1.062, 1.401]) and a lower educational level of the parents (OR = -0.879; 95% CI[0.202, 0.832]), meanwhile poor social support predicted most ADHD symptoms OR = -0.086; 95% CI[0.838, 1]) and executive dysfunctions OR = -0.661; 95% CI[0.313, 0.845]. Lower parental education predicted both externalizing and internalizing behavior.

Conclusions

Maternal age-related factors were the main predictors of neurodevelopmental disorders in offspring, rather than maternal age. The performance of prenatal interventions in pregnant women with advanced age and anxious depressive symptoms or adverse social situation, is crucial to reduce the risk of neurodevelopmental disorders in the offspring. Likewise, being able to carry out an early detection of childhood psychopathology would allow the implementation of resources that improve their long-term prognosis.

Disclosure

No significant relationships.

Keywords

predictorPSYCHOPATOLOGYmaternal age
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S146
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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