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The DiSCoVeR trial – first look at patient training and their expectations regarding a new, innovative treatment

Published online by Cambridge University Press:  01 September 2022

L. Rubene ,
L. Konošonoka ,
M. Nahum ,
F. Padberg ,
D. Bavelier ,
F. Hummel ,
O. Bonne  and
E. Rancans
L. Rubene*
Affiliation:
Riga Stradins University, Department Of Psychiatry And Addiction Medicine, Riga, Latvia
L. Konošonoka
Affiliation:
Riga Stradins University, Department Of Psychiatry And Addiction Medicine, Riga, Latvia
M. Nahum
Affiliation:
The Hebrew University of Jerusalem, School Of Occupational Therapy, Faculty Of Medicine, Jerusalem, Israel
F. Padberg
Affiliation:
University Hospital, LMU Munich, Department Of Psychiatry And Psychotherapy, Munich, Germany
D. Bavelier
Affiliation:
University of Geneva, Faculty Of Psychology And Educational Sciences, Geneva, Switzerland
F. Hummel
Affiliation:
Swiss Federal Institute of Technology, Centre For Neuroprosthetics And Brain Mind Institute, Geneva, Switzerland
O. Bonne
Affiliation:
The Hebrew University of Jerusalem, Department Of Psychiatry, Hadassah Medical Center, Faculty Of Medicine, Jerusalem, Israel
E. Rancans
Affiliation:
Riga Stradins University, Department Of Psychiatry And Addiction Medicine, Riga, Latvia
*
*Corresponding author.

Abstract

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Introduction

The DiSCoVeR trial is a multi-site, double-blind, sham controlled, randomized controlled trial (RCT) investigating the feasibility and efficacy of an innovative, self-applied treatment approach for patients suffering from major depressive disorder (MDD). The treatment approach incorporates non-invasive brain stimulation, i.e. prefrontal transcranial direct current stimulation (tDCS), and a videogame designed to enhance emotional cognitive control. This treatment is aimed to be applied at home and monitored remotely.

Objectives

In this study we are looking at the first 10 single-site patients and comparing expected in person visits (according to the study protocol) versus actual in person visits as well as looking at the patients initial view of the therapy using the therapy evaluation form (CEQ) submitted after the 5th session.

Methods

Before continuing to self-administer the treatment at home patients undergo supervised training, during clinic visits, for up to 5 sessions. At the end of the 5th session, they are asked to fill out a therapy evaluation form (CEQ).

Results

Patients needed on average 2.3 in person training sessions before continuing the intervention remotely. Nine patients completed CEQ. Results show that on average patients thought that this course will be 4.78 (with probability 95% CI 4.74 to 4.82) points successful at raising their level of functioning and thought that their functioning will have increased on average by 37.8% (CI 37.2% to 38.4%) by the end of the study.

Conclusions

Patients needed less than half of planned in person training visits. Most patients felt like they will gain some improvement from this intervention.

Disclosure

No significant relationships.

Keywords

transcranial direct current stimulationmajor depressive disordercognitive control videogameexpectations
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S298
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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