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Diffusion tensor imaging in schizophrenia

Published online by Cambridge University Press:  16 April 2020

Marinos Kyriakopoulos ,
Theodoros Bargiotas ,
Gareth J. Barker  and
Sophia Frangou
Marinos Kyriakopoulos*
Affiliation:
Section of Neurobiology of Psychosis Institute of Psychiatry, King's College London, London, UK
Theodoros Bargiotas
Affiliation:
Section of Neurobiology of Psychosis Institute of Psychiatry, King's College London, London, UK
Gareth J. Barker
Affiliation:
Department of Clinical Neuroscience, Centre for Neuroimaging Sciences, Institute of Psychiatry, King's College London, London, UK
Sophia Frangou
Affiliation:
Section of Neurobiology of Psychosis Institute of Psychiatry, King's College London, London, UK
*
∗Corresponding author. Tel.: +44 20 78480425. E-mail address: [email protected] (M. Kyriakopoulos).
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Abstract

Diffusion tensor imaging (DTI) is a magnetic resonance imaging technique that is increasingly being used for the non-invasive evaluation of brain white matter abnormalities. In this review, we discuss the basic principles of DTI, its roots and the contribution of European centres in its development, and we review the findings from DTI studies in schizophrenia. We searched EMBASE, PubMed, PsychInfo, and Medline from February 1998 to December 2006 using as keywords ‘schizophrenia’, ‘diffusion’, ‘tensor’, and ‘DTI’. Forty studies fulfilling the inclusion criteria of this review were included and systematically reviewed. White matter abnormalities in many diverse brain regions were identified in schizophrenia. Although the findings are not completely consistent, frontal and temporal white matter seems to be more commonly affected. Limitations and future directions of this method are discussed.

Keywords

SchizophreniaDiffusion tensor imagingWhite matterAnisotropyTractography
Type
Original article
Information
European Psychiatry , Volume 23 , Issue 4 , June 2008 , pp. 255 - 273
Copyright
Copyright © European Psychiatric Association 2008

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References

Agartz, I.Andersson, J.L.Skare, S.Abnormal brain white matter in schizophrenia: a diffusion tensor imaging study. Neuroreport 2001;12:2251–2254.CrossRefGoogle ScholarPubMed
Alexander, D.C.Barker, G.J.Optimal imaging parameters for fibre orientation estimation in diffusion MRI. Neuroimage 2005;27:357–367.CrossRefGoogle Scholar
Alexander, D.C.Barker, G.J.Arridge, S.R.Detection and modelling of non-gaussian apparent diffusion coefficient profiles in clinical human brain data. Magn Reson Med 2002;48:331–340.CrossRefGoogle Scholar
Andreasen, N.C.Paradiso, S.O'Leary, D.S.“Cognitive dysmetria” as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry?. Schizophr Bull 1998;24:203–218.CrossRefGoogle ScholarPubMed
Ardekani, B.A.Nierenberg, J.Hoptman, M.J.Javitt, D.C.Lim, K.O.MRI study of white matter diffusion anisotropy in schizophrenia. Neuroreport 2003;14:2025–2029.CrossRefGoogle Scholar
Barnea-Goraly, N.Kwon, H.Menon, V.Eliez, S.Lotspeich, L.Reiss, A.L.White matter structure in autism: preliminary evidence from diffusion tensor imaging. Biol Psychiatry 2004;55:323–326.CrossRefGoogle ScholarPubMed
Basser, P.J.Mattiello, J.LeBihan, D.MR diffusion tensor spectroscopy and imaging. Biophys J 1994;66:259–267.CrossRefGoogle ScholarPubMed
Basser, P.J.Mattiello, J.LeBihan, D.Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B 1994;103:247–254.CrossRefGoogle ScholarPubMed
Basser, P.J.Pierpaoli, C.Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 1996;111:209–219.CrossRefGoogle ScholarPubMed
Beaulieu, C.The basis of anisotropic water diffusion in the nervous system – a technical review. NMR Biomed 2002;15:435–455.CrossRefGoogle ScholarPubMed
Begré, S.Federspiel, A.Kiefer, C.Schroth, G.Dierks, T.Strik, W.K.Reduced hippocampal anisotropy related to anteriorization of alpha EEG in schizophrenia. Neuroreport 2003;14:739–742.CrossRefGoogle Scholar
Behrens, T.E.Woolrich, M.W.Jenkinson, M.Johansen-Berg, H.Nunes, R.G.Clare, S.et al.Characterization and propagation of uncertainty in diffusion-weighted MR imaging. Magn Reson Med 2003;50:1077–1088.CrossRefGoogle ScholarPubMed
Benes, F.M.Emerging principles of altered neural circuitry in schizophrenia. Brain Res Brain Res Rev 2000;31:251–269.CrossRefGoogle Scholar
Blain, C.R.Barker, G.J.Jarosz, J.M.Coyle, N.A.Landau, S.Brown, R.G.et al.Measuring brain stem and cerebellar damage in parkinsonian syndromes using diffusion tensor MRI. Neurology 2006;67:2199–2205.CrossRefGoogle ScholarPubMed
Bonekamp, D.Nagae, L.M.Degaonkar, M.Matson, M.Abdalla, W.M.Barker, P.B.et al.Diffusion tensor imaging in children and adolescents: reproducibility, hemispheric, and age-related differences. Neuroimage 2007;34:733–742.CrossRefGoogle ScholarPubMed
Buchsbaum, M.S.Friedman, J.Buchsbaum, B.R.Chu, K.W.Hazlett, E.A.Newmark, R.et al.Diffusion tensor imaging in schizophrenia. Biol Psychiatry 2006;60:1181–1187.CrossRefGoogle Scholar
Buchsbaum, M.S.Schoenknecht, P.Torosjan, Y.Newmark, R.Chu, K.W.Mitelman, S.et al.Diffusion tensor imaging of frontal lobe white matter tracts in schizophrenia. Ann Gen Psychiatry 2006;5:19.CrossRefGoogle Scholar
Buchsbaum, M.S.Tang, C.Y.Peled, S.Gudbjartsson, H.Lu, D.Hazlett, E.A.et al.MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia. Neuroreport 1998;9:425–430.CrossRefGoogle Scholar
Burns, J.Job, D.Bastin, M.E.Whalley, H.Macgillivray, T.Johnstone, E.C.et al.Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study. Br J Psychiatry 2003;182:439–443.CrossRefGoogle ScholarPubMed
Butler, P.D.Hoptman, M.J.Nierenberg, J.Foxe, J.J.Javitt, D.C.Lim, K.O.Visual white matter integrity in schizophrenia. Am J Psychiatry 2006;163:2011–2013.CrossRefGoogle Scholar
Caan, M.W.Vermeer, K.A.van Vliet, L.J.Majoie, C.B.Peters, B.D.den Heeten, G.J.et al.Shaving diffusion tensor images in discriminant analysis: a study into schizophrenia. Med Image Anal 2006;10:841–849.CrossRefGoogle ScholarPubMed
Catani, M.Howard, R.J.Pajevic, S.Jones, D.K.Virtual in vivo interactive dissection of white matter fasciculi in the human brain. Neuroimage 2002;17:77–94.CrossRefGoogle ScholarPubMed
Catani, M.Jones, D.K.ffytche, D.H.Perisylvian language networks of the human brain. Ann Neurol 2005;57:8–16.CrossRefGoogle ScholarPubMed
Chabert, S.Molko, N.Cointepas, Y.Le Roux, P.Le Bihan, D.Diffusion tensor imaging of the human optic nerve using a non-CPMG fast spin echo sequence. J Magn Reson Imaging 2005;22:307–310.CrossRefGoogle ScholarPubMed
Christensen, J.Holcomb, J.Garver, D.L.State-related changes in cerebral white matter may underlie psychosis exacerbation. Psychiatry Res 2004;130:71–78.CrossRefGoogle ScholarPubMed
Clark, C.A.Barker, G.J.Tofts, P.S.Magnetic resonance diffusion imaging of the human cervical spinal cord in vivo. Magn Reson Med 1999;41:1269–1273.3.0.CO;2-2>CrossRefGoogle ScholarPubMed
Dolan, R.J.Fletcher, P.C.McKenna, P.Friston, K.J.Frith, C.D.Abnormal neural integration related to cognition in schizophrenia. Acta Psychiatr Scand Suppl 1999;395:58–67.CrossRefGoogle ScholarPubMed
Dubois, J.Poupon, C.Lethimonnier, F.Le Bihan, D.Optimized diffusion gradient orientation schemes for corrupted clinical DTI data sets. MAGMA 2006;19:134–143.CrossRefGoogle ScholarPubMed
Federspiel, A.Begre, S.Kiefer, C.Schroth, G.Strik, W.K.Dierks, T.Alterations of white matter connectivity in first episode schizophrenia. Neurobiol Dis 2006;22:702–709.CrossRefGoogle ScholarPubMed
Filidoro, L.Dietrich, O.Weber, J.Rauch, E.Oerther, T.Wick, M.et al.High-resolution diffusion tensor imaging of human patellar cartilage: feasibility and preliminary findings. Magn Reson Med 2005;53:993–998.CrossRefGoogle ScholarPubMed
Foong, J.Maier, M.Clark, C.A.Barker, G.J.Miller, D.H.Ron, M.A.Neuropathological abnormalities of the corpus callosum in schizophrenia: a diffusion tensor imaging study. J Neurol Neurosurg Psychiatr 2000;68:242–244.CrossRefGoogle ScholarPubMed
Foong, J.Symms, M.R.Barker, G.J.Maier, M.Miller, D.H.Ron, M.A.Investigating regional white matter in schizophrenia using diffusion tensor imaging. Neuroreport 2002;13:333–336.CrossRefGoogle ScholarPubMed
Frith, C.The neural basis of hallucinations and delusions. C R Biol 2005;328:169–175.CrossRefGoogle ScholarPubMed
Frith, C.D.Blakemore, S.Wolpert, D.M.Explaining the symptoms of schizophrenia: abnormalities in the awareness of action. Brain Res Brain Res Rev 2000;31:357–363.CrossRefGoogle ScholarPubMed
Hakak, Y.Walker, J.R.Li, C.Wong, W.H.Davis, K.L.Buxbaum, J.D.et al.Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci U S A 2001;98:4746–4751.CrossRefGoogle ScholarPubMed
Hao, Y.Liu, Z.Jiang, T.Gong, G.Liu, H.Tan, L.et al.White matter integrity of the whole brain is disrupted in first-episode schizophrenia. Neuroreport 2006;17:23–26.CrossRefGoogle ScholarPubMed
Harrison, P.J.The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 1999;122:593–624.CrossRefGoogle ScholarPubMed
Heaton, K.K.Wisconsin card sorting test manual. Odessa, FL: Psychological Assessment Resources; 1981.Google Scholar
Hof, P.R.Haroutunian, V.Friedrich, V.L. Jr.Byne, W.Buitron, C.Perl, D.P.et al.Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia. Biol Psychiatry 2003;53:1075–1085.CrossRefGoogle Scholar
Hoptman, M.J.Ardekani, B.A.Butler, P.D.Nierenberg, J.Javitt, D.C.Lim, K.O.DTI and impulsivity in schizophrenia: a first voxelwise correlational analysis. Neuroreport 2004;15:2467–2470.CrossRefGoogle ScholarPubMed
Hoptman, M.J.Volavka, J.Johnson, G.Weiss, E.Bilder, R.M.Lim, K.O.Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: a preliminary study. Biol Psychiatry 2002;52:9–14.CrossRefGoogle ScholarPubMed
Horsfield, M.A.Jones, D.K.Applications of diffusion-weighted and diffusion tensor MRI to white matter diseases – a review. NMR Biomed 2002;15:570–577.CrossRefGoogle ScholarPubMed
Hubl, D.Koenig, T.Strik, W.Federspiel, A.Kreis, R.Boesch, C.et al.Pathways that make voices: white matter changes in auditory hallucinations. Arch Gen Psychiatry 2004;61:658–668.CrossRefGoogle ScholarPubMed
Jones, D.K.Catani, M.Pierpaoli, C.Reeves, S.J.Shergill, S.S.O'Sullivan, M.et al.Age effects on diffusion tensor magnetic resonance imaging tractography measures of frontal cortex connections in schizophrenia. Hum Brain Mapp 2006;27:230–238.CrossRefGoogle Scholar
Jones, D.K.Catani, M.Pierpaoli, C.Reeves, S.J.Shergill, S.S.O'Sullivan, M.et al.A diffusion tensor magnetic resonance imaging study of frontal cortex connections in very-late-onset schizophrenia-like psychosis. Am J Geriatr Psychiatry 2005;13:1092–1099.CrossRefGoogle ScholarPubMed
Jones, D.K.Griffin, L.D.Alexander, D.C.Catani, M.Horsfield, M.A.Howard, R.et al.Spatial normalization and averaging of diffusion tensor MRI data sets. Neuroimage 2002;17:592–617.CrossRefGoogle ScholarPubMed
Jones, D.K.Horsfield, M.A.Simmons, A.Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging. Magn Reson Med 1999;42:515–525.3.0.CO;2-Q>CrossRefGoogle ScholarPubMed
Jones, D.K.Williams, S.C.Gasston, D.Horsfield, M.A.Simmons, A.Howard, R.Isotropic resolution diffusion tensor imaging with whole brain acquisition in a clinically acceptable time. Hum Brain Mapp 2002;15:216–230.CrossRefGoogle Scholar
Kalus, P.Buri, C.Slotboom, J.Gralla, J.Remonda, L.Dierks, T.et al.Volumetry and diffusion tensor imaging of hippocampal subregions in schizophrenia. Neuroreport 2004;15:867–871.CrossRefGoogle Scholar
Kalus, P.Slotboom, J.Gallinat, J.Federspiel, A.Gralla, J.Remonda, L.et al.New evidence for involvement of the entorhinal region in schizophrenia: a combined MRI volumetric and DTI study. Neuroimage 2005;24:1122–1129.CrossRefGoogle ScholarPubMed
Kalus, P.Slotboom, J.Gallinat, J.Mahlberg, R.Cattapan-Ludewig, K.Wiest, R.et al.Examining the gateway to the limbic system with diffusion tensor imaging: the perforant pathway in dementia. Neuroimage 2006;30:713–720.CrossRefGoogle ScholarPubMed
Kalus, P.Slotboom, J.Gallinat, J.Wiest, R.Ozdoba, C.Federspiel, A.et al.The amygdala in schizophrenia: a trimodal magnetic resonance imaging study. Neurosci Lett 2005;375:151–156.CrossRefGoogle ScholarPubMed
Kanaan, R.A.Kim, J.S.Kaufmann, W.E.Pearlson, G.D.Barker, G.J.McGuire, P.K.Diffusion tensor imaging in schizophrenia. Biol Psychiatry 2005;58:921–929.CrossRefGoogle Scholar
Kanaan, R.A.Shergill, S.S.Barker, G.J.Catani, M.Ng, V.W.Howard, R.et al.Tract-specific anisotropy measurements in diffusion tensor imaging. Psychiatry Res 2006;146:73–82.CrossRefGoogle ScholarPubMed
Kitamura, H.Matsuzawa, H.Shioiri, T.Someya, T.Kwee, I.L.Nakada, T.Diffusion tensor analysis in chronic schizophrenia. A preliminary study on a high-field (3.0 T) system. Eur Arch Psychiatry Clin Neurosci 2005;255:313–318.CrossRefGoogle Scholar
Kubicki, M.McCarley, R.Westin, C.F.Park, H.J.Maier, S.Kikinis, R.et al.A review of diffusion tensor imaging studies in schizophrenia. J Psychiatr Res 2007;41:15–30.CrossRefGoogle Scholar
Kubicki, M.Park, H.Westin, C.F.Nestor, P.G.Mulkern, R.V.Maier, S.E.et al.DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity. Neuroimage 2005;26:1109–1118.CrossRefGoogle ScholarPubMed
Kubicki, M.Westin, C.F.Maier, S.E.Frumin, M.Nestor, P.G.Salisbury, D.F.et al.Uncinate fasciculus findings in schizophrenia: a magnetic resonance diffusion tensor imaging study. Am J Psychiatry 2002;159:813–820.CrossRefGoogle ScholarPubMed
Kubicki, M.Westin, C.F.Maier, S.E.Mamata, H.Frumin, M.Ersner-Hershfield, H.et al.Diffusion tensor imaging and its application to neuropsychiatric disorders. Harv Rev Psychiatry 2002;10:324–336.CrossRefGoogle ScholarPubMed
Kubicki, M.Westin, C.F.McCarley, R.W.Shenton, M.E.The application of DTI to investigate white matter abnormalities in schizophrenia. Ann N Y Acad Sci 2005;1064:134–148.CrossRefGoogle Scholar
Kubicki, M.Westin, C.F.Nestor, P.G.Wible, C.G.Frumin, M.Maier, S.E.et al.Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study. Biol Psychiatry 2003;54:1171–1180.CrossRefGoogle ScholarPubMed
Kumra, S.Ashtari, M.Cervellione, K.Henderson, I.Kester, H.Roofeh, D.et al.White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study. J Am Acad Child Adolesc Psychiatry 2005;44:937–941.CrossRefGoogle ScholarPubMed
Kumra, S.Ashtari, M.McMeniman, M.Vodel, J.Augustin, R.Becker, D.E.et al.Reduced frontal white matter integrity in early-onset schizophrenia: a preliminary study. Biol Psychiatry 2004;55:1138–1145.CrossRefGoogle ScholarPubMed
Kuroki, N.Kubicki, M.Nestor, P.G.Salisbury, D.F.Park, H.J.Levitt, J.J.et al.Fornix integrity and hippocampal volume in male schizophrenic patients. Biol Psychiatry 2006;60:22–31.CrossRefGoogle ScholarPubMed
Lawrie, S.M.Abukmeil, S.S.Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies. Br J Psychiatry 1998;172:110–120.CrossRefGoogle ScholarPubMed
Le Bihan, D.Breton, E.Lallemand, D.Grenier, P.Cabanis, E.Laval-Jeantet, M.MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 1986;161:401–407.CrossRefGoogle ScholarPubMed
Le Bihan, D.Mangin, J.F.Poupon, C.Clark, C.A.Pappata, S.Molko, N.et al.Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging 2001;13:534–546.CrossRefGoogle ScholarPubMed
Le Bihan, D.Poupon, C.Amadon, A.Lethimonnier, F.Artifacts and pitfalls in diffusion MRI. J Magn Reson Imaging 2006;24:478–488.CrossRefGoogle ScholarPubMed
Lezak, M.Neuropsychological assessment. New York: Oxford University Press; 1983.Google Scholar
Lim, K.O.Ardekani, B.A.Nierenberg, J.Butler, P.D.Javitt, D.C.Hoptman, M.J.Voxelwise correlational analyses of white matter integrity in multiple cognitive domains in schizophrenia. Am J Psychiatry 2006;163:2008–2010.CrossRefGoogle Scholar
Lim, K.O.Hedehus, M.Moseley, M.de Crespigny, A.Sullivan, E.V.Pfefferbaum, A.Compromised white matter tract integrity in schizophrenia inferred from diffusion tensor imaging. Arch Gen Psychiatry 1999;56:367–374.CrossRefGoogle ScholarPubMed
Lim, K.O.Helpern, J.A.Neuropsychiatric applications of DTI – a review. NMR Biomed 2002;15:587–593.CrossRefGoogle ScholarPubMed
Lori, N.F.Akbudak, E.Shimony, J.S.Cull, T.S.Snyder, A.Z.Guillory, R.K.et al.Diffusion tensor fiber tracking of human brain connectivity: aquisition methods, reliability analysis and biological results. NMR Biomed 2002;15:494–515.CrossRefGoogle ScholarPubMed
Mabbott, D.J.Noseworthy, M.Bouffet, E.Laughlin, S.Rockel, C.White matter growth as a mechanism of cognitive development in children. Neuroimage 2006;33:936–946.CrossRefGoogle ScholarPubMed
Minami, T.Nobuhara, K.Okugawa, G.Takase, K.Yoshida, T.Sawada, S.et al.Diffusion tensor magnetic resonance imaging of disruption of regional white matter in schizophrenia. Neuropsychobiology 2003;47:141–145.CrossRefGoogle Scholar
Mitelman, S.A.Newmark, R.E.Torosjan, Y.Chu, K.W.Brickman, A.M.Haznedar, M.M.et al.White matter fractional anisotropy and outcome in schizophrenia. Schizophr Res 2006;87:138–159.CrossRefGoogle Scholar
Mori, S.Wanaka, S.Nagae-Poetscher, L.M.van Zijl, P.C.M.MRI atlas of human white matter. Amsterdam: Elsevier Science; 2005.Google Scholar
Nagy, Z.Westerberg, H.Skare, S.Andersson, J.L.Lilja, A.Flodmark, O.et al.Preterm children have disturbances of white matter at 11 years of age as shown by diffusion tensor imaging. Pediatr Res 2003;54:672–679.CrossRefGoogle ScholarPubMed
Nestor, P.G.Kubicki, M.Gurrera, R.J.Niznikiewicz, M.Frumin, M.McCarley, R.W.et al.Neuropsychological correlates of diffusion tensor imaging in schizophrenia. Neuropsychology 2004;18:629–637.CrossRefGoogle Scholar
Nestor, P.G.Kubicki, M.Spencer, K.M.Niznikiewicz, M.McCarley, R.W.Shenton, M.E.Attentional networks and cingulum bundle in chronic schizophrenia. Schizophr Res 2007;90:308–315.CrossRefGoogle ScholarPubMed
Okugawa, G.Nobuhara, K.Minami, T.Takase, K.Sugimoto, T.Saito, Y.et al.Neural disorganization in the superior cerebellar peduncle and cognitive abnormality in patients with schizophrenia: a diffusion tensor imaging study. Prog Neuropsychopharmacol Biol Psychiatry 2006;30:1408–1412.CrossRefGoogle ScholarPubMed
Okugawa, G.Nobuhara, K.Minami, T.Tamagaki, C.Takase, K.Sugimoto, T.et al.Subtle disruption of the middle cerebellar peduncles in patients with schizophrenia. Neuropsychobiology 2004;50:119–123.CrossRefGoogle ScholarPubMed
Okugawa, G.Nobuhara, K.Sugimoto, T.Kinoshita, T.Diffusion tensor imaging study of the middle cerebellar peduncles in patients with schizophrenia. Cerebellum 2005;4:123–127.CrossRefGoogle ScholarPubMed
Park, H.J.Westin, C.F.Kubicki, M.Maier, S.E.Niznikiewicz, M.Baer, A.et al.White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study. Neuroimage 2004;23:213–223.CrossRefGoogle ScholarPubMed
Parker, G.J.Alexander, D.C.Probabilistic Monte Carlo based mapping of cerebral connections utilising whole-brain crossing fibre information. Inf Proc Med Imaging 2003;18:684–695.Google ScholarPubMed
Parker, G.J.Haroon, H.A.Wheeler-Kingshott, C.A.A framework for a streamline-based probabilistic index of connectivity (PICo) using a structural interpretation of MRI diffusion measurements. J Magn Reson Imaging 2003;18:242–254.CrossRefGoogle ScholarPubMed
Pfefferbaum, A.Sullivan, E.V.Hedehus, M.Adalsteinsson, E.Lim, K.O.Moseley, M.In vivo detection and functional correlates of white matter microstructural disruption in chronic alcoholism. Alcohol Clin Exp Res 2000;24:1214–1221.CrossRefGoogle ScholarPubMed
Pfefferbaum, A.Sullivan, E.V.Hedehus, M.Lim, K.O.Adalsteinsson, E.Moseley, M.Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging. Magn Reson Med 2000;44:259–268.3.0.CO;2-6>CrossRefGoogle ScholarPubMed
Pierpaoli, C.Barnett, A.Pajevic, S.Chen, R.Penix, L.R.Virta, A.et al.Water diffusion changes in Wallerian degeneration and their dependence on white matter architecture. Neuroimage 2001;13:1174–1185.CrossRefGoogle ScholarPubMed
Pierpaoli, C.Jezzard, P.Basser, P.J.Barnett, A.Di Chiro, G.Diffusion tensor MR imaging of the human brain. Radiology 1996;201:637–648.CrossRefGoogle ScholarPubMed
Plessen, K.J.Gruner, R.Lundervold, A.Hirsch, J.G.Xu, D.Bansal, R.et al.Reduced white matter connectivity in the corpus callosum of children with Tourette syndrome. J Child Psychol Psychiatry 2006;47:1013–1022.CrossRefGoogle ScholarPubMed
Price, G.Bagary, M.S.Cercignani, M.Altmann, D.R.Ron, M.A.The corpus callosum in first episode schizophrenia: a diffusion tensor imaging study. J Neurol Neurosurg Psychiatr 2005;76:585–587.CrossRefGoogle ScholarPubMed
Ries, M.Jones, R.A.Basseau, F.Moonen, C.T.Grenier, N.Diffusion tensor MRI of the human kidney. J Magn Reson Imaging 2001;14:42–49.CrossRefGoogle ScholarPubMed
Rose, S.E.Chalk, J.B.Janke, A.L.Strudwick, M.W.Windus, L.C.Hannah, D.E.et al.Evidence of altered prefrontal-thalamic circuitry in schizophrenia: an optimized diffusion MRI study. Neuroimage 2006;32:16–22.CrossRefGoogle ScholarPubMed
Schlosser, R.G.Nenadic, I.Wagner, G.Gullmar, D.von Consbruch, K.Kohler, S.et al.White matter abnormalities and brain activation in schizophrenia: A combined DTI and fMRI study. Schizophr Res 2007;89:1–11.CrossRefGoogle ScholarPubMed
Schmid, P.Jaermann, T.Boesiger, P.Niederer, P.F.Lunkenheimer, P.P.Cryer, C.W.et al.Ventricular myocardial architecture as visualised in postmortem swine hearts using magnetic resonance diffusion tensor imaging. Eur J Cardiothorac Surg 2005;27:468–472.CrossRefGoogle ScholarPubMed
Schmithorst, V.J.Wilke, M.Dardzinski, B.J.Holland, S.K.Correlation of white matter diffusivity and anisotropy with age during childhood and adolescence: a cross-sectional diffusion-tensor MR imaging study. Radiology 2002;222:212–218.CrossRefGoogle ScholarPubMed
Schneider, J.F.Il'yasov, K.A.Boltshauser, E.Hennig, J.Martin, E.Diffusion tensor imaging in cases of adrenoleukodystrophy: preliminary experience as a marker for early demyelination?. Am J Neuroradiol 2003;24:819–824.Google ScholarPubMed
Shenton, M.E.Dickey, C.C.Frumin, M.McCarley, R.W.A review of MRI findings in schizophrenia. Schizophr Res 2001;49:1–52.CrossRefGoogle Scholar
Shin, Y.W.Kwon, J.S.Ha, T.H.Park, H.J.Kim, D.J.Hong, S.B.et al.Increased water diffusivity in the frontal and temporal cortices of schizophrenic patients. Neuroimage 2006;30:1285–1291.CrossRefGoogle ScholarPubMed
Smith, S.M.Jenkinson, M.Johansen-Berg, H.Rueckert, D.Nichols, T.E.Mackay, C.E.et al.Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 2006;31:1487–1505.CrossRefGoogle ScholarPubMed
Steel, R.M.Bastin, M.E.McConnell, S.Marshall, I.Cunningham-Owens, D.G.Lawrie, S.M.et al.Diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (1H MRS) in schizophrenic subjects and normal controls. Psychiatry Res 2001;106:161–170.CrossRefGoogle ScholarPubMed
Sullivan, E.V.Pfefferbaum, A.Diffusion tensor imaging in normal aging and neuropsychiatric disorders. Eur J Radiol 2003;45:244–255.CrossRefGoogle ScholarPubMed
Sun, Z.Wang, F.Cui, L.Breeze, J.Du, X.Wang, X.et al.Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study. Neuroreport 2003;14:1833–1836.CrossRefGoogle ScholarPubMed
Szeszko, P.R.Ardekani, B.A.Ashtari, M.Kumra, S.Robinson, D.G.Sevy, S.et al.White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging study. Am J Psychiatry 2005;162:602–605.CrossRefGoogle ScholarPubMed
Thivard, L.Adam, C.Hasboun, D.Clemenceau, S.Dezamis, E.Lehericy, S.et al.Interictal diffusion MRI in partial epilepsies explored with intracerebral electrodes. Brain 2006;129:375–385.CrossRefGoogle ScholarPubMed
Tournier, J.D.Calamante, F.Gadian, D.G.Connelly, A.Direct estimation of the fiber orientation density function from diffusion-weighted MRI data using spherical deconvolution. Neuroimage 2004;23:1176–1185.CrossRefGoogle ScholarPubMed
Wang, F.Sun, Z.Cui, L.Du, X.Wang, X.Zhang, H.et al.Anterior cingulum abnormalities in male patients with schizophrenia determined through diffusion tensor imaging. Am J Psychiatry 2004;161:573–575.CrossRefGoogle ScholarPubMed
Wang, F.Sun, Z.Du, X.Wang, X.Cong, Z.Zhang, H.et al.A diffusion tensor imaging study of middle and superior cerebellar peduncle in male patients with schizophrenia. Neurosci Lett 2003;348:135–138.CrossRefGoogle ScholarPubMed
Wechsler, D.The Wechsler memory scale. 3rd ed.San Antonio: Tex: Psychological Corp (Harcourt); 1997.Google Scholar
Wechsler, D.Wechsler adult intelligence scale. 3rd ed.San Antonio: Tex: Psychological Corp (Harcourt); 1997.Google Scholar
Wheeler-Kingshott, C.A.M.Hickman, S.J.Parker, G.J.M.Ciccarelli, O.Symms, M.R.Miller, D.H.et al.Investigating cervical spinal cord structure using axial diffusion tensor imaging. NeuroImage 2002;16:93–102.CrossRefGoogle ScholarPubMed
Wheeler-Kingshott, C.A.M.Parker, G.J.M.Symms, M.R.Hickman, S.J.Tofts, P.S.Miller, D.H.et al.ADC mapping of the human optic nerve: increased resolution, coverage and reliability with CSF-suppressed ZOOM-EPI. Magn Reson Med 2002;47:24–31.CrossRefGoogle ScholarPubMed
White, T.Kendi, A.T.Lehericy, S.Kendi, M.Karatekin, C.Guimaraes, A.et al.Disruption of hippocampal connectivity in children and adolescents with schizophrenia – a voxel-based diffusion tensor imaging study. Schizophr Res 2007;90:302–307.CrossRefGoogle ScholarPubMed
Wolkin, A.Choi, S.J.Szilagyi, S.Sanfilipo, M.Rotrosen, J.P.Lim, K.O.Inferior frontal white matter anisotropy and negative symptoms of schizophrenia: a diffusion tensor imaging study. Am J Psychiatry 2003;160:572–574.CrossRefGoogle ScholarPubMed
Wright, I.C.Rabe-Hesketh, S.Woodruff, P.W.David, A.S.Murray, R.M.Bullmore, E.T.Meta-analysis of regional brain volumes in schizophrenia. Am J Psychiatry 2000;157:16–25.CrossRefGoogle Scholar
Taylor, W.D.Hsu, E.Krishnan, K.R.MacFall, J.R.Diffusion tensor imaging: background, potential, and utility in psychiatric research. Biol Psychiatry 2004;55:201–207.CrossRefGoogle ScholarPubMed
Davis, K.L.Stewart, D.G.Friedman, J.I.Buchsbaum, M.Harvey, P.D.Hof, P.R.et al.White matter changes in schizophrenia: evidence for myelin-related dysfunction. Arch Gen Psychiatry 2003;60:443–456.CrossRefGoogle ScholarPubMed
Spitzer, R.L.Endicott, J.Robins, E.Research diagnostic criteria: rationale and reliability. Arch Gen Psychiatry 1978;35:773–782.CrossRefGoogle ScholarPubMed
Mendelsohn, A.Strous, R.D.Bleich, M.Assaf, Y.Hendler, T.Regional axonal abnormalities in first episode schizophrenia: preliminary evidence based on high b-value diffusion-weighted imaging. Psychiatry Res 2006;146:223–229.CrossRefGoogle ScholarPubMed
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