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Differentiation of adoptees at high versus low genetic risk for schizophrenia by adjusted MMPI indices

Published online by Cambridge University Press:  16 April 2020

Virva Siira ,
Karl-Erik Wahlberg ,
Jouko Miettunen ,
Pekka Tienari  and
Kristian Làksy
Virva Siira*
Affiliation:
Department of Psychiatry, University of Oulu, Box 5000, 90014Oulu, Finland
Karl-Erik Wahlberg
Affiliation:
Department of Psychiatry, University of Oulu, Box 5000, 90014Oulu, Finland
Jouko Miettunen
Affiliation:
Department of Psychiatry, University of Oulu, Box 5000, 90014Oulu, Finland
Pekka Tienari
Affiliation:
Department of Psychiatry, University of Oulu, Box 5000, 90014Oulu, Finland
Kristian Làksy
Affiliation:
Department of Psychiatry, University of Oulu, Box 5000, 90014Oulu, Finland
*
*Corresponding author. E-mail address: [email protected] (V. Siira).
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Abstract

The aim of this study was to find potential signs of genetic vulnerability to schizophrenia. The differences between adoptees at high genetic risk for schizophrenia (their biological mother had a schizophrenia spectrum disorder) and control adoptees of non-schizophrenia spectrum biological mothers were assessed. The comparisons between these groups were based on the Minnesota Multiphasic Personality Inventory (MMPI) test's subscale scores adjusted by gender, age at MMPI assessment, age at placement into the adoptive family and social class. The subjects were a subsamples of a total of 182 tested adoptees and 136 mentally healthy adoptees in the Finnish Adoptive Family Study. The high-risk group was found to be distinguishable from the low-risk group based on deviant scores on the Hostility, Hypomania and Lie scales. These scales may measure genetic vulnerability and also possibly be indicative of psychometric deviance predicting future onset of schizophrenia.

Keywords

SchizophreniaMMPIDemographic variablesAdoption studyHigh-risk study
Type
Original articles
Information
European Psychiatry , Volume 21 , Issue 4 , June 2006 , pp. 245 - 250
Copyright
Copyright © European Psychiatric Association 2006

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