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Differential illness intrusiveness associated with sleep-promoting medications

Published online by Cambridge University Press:  16 April 2020

GM Devins ,
M Flanigan ,
JAE Fleming ,
R Morehouse ,
A Moscovitch ,
J Plamondon ,
L Reinish  and
CM Shapiro
GM Devins
Affiliation:
Culture, Community, and Health Studies, Clarke Institute of Psychiatry, 250 College Street, Toronto, OntarioM5T 1R8, Canada University of Toronto, Canada The Toronto Hospital, Canada
M Flanigan
Affiliation:
The Toronto Hospital, Canada
JAE Fleming
Affiliation:
University of British Columbia, Canada
R Morehouse
Affiliation:
Dalhousie University, Canada
A Moscovitch
Affiliation:
University of Calgary, Canada
J Plamondon
Affiliation:
Laval University, Canada
L Reinish
Affiliation:
The Toronto Hospital, Canada
CM Shapiro
Affiliation:
University of Toronto, Canada
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Summary

Differences in daytime sleepiness, lifestyle disruptions, and emotional distress were compared across nine groups taking sleep-promoting substances. Groups included individuals taking zopiclone (n = 274), amitriptyline (n = 107), lorazepam (n = 258), oxazepam (n= 141), diphenhydramine HCl (n = 99), triazolam(n = 137), long acting benzodiazepines (n = 120), temazepam (n = 176), and miscellaneous other medications (n = 286). Data were gathered by self-report, using standardized instruments in a mail-back questionnaire procedure. Respondents included the first 1,598 participants enrolled in a Canadian multicentre project, including six sites attached to academic psychiatric units. Results indicated that quality of life effects differed across groups in both daytime sleepiness and lifestyle disruptions (illness intrusiveness), but not in depressive symptoms. Daytime sleepiness was significantly higher among people taking diphenhydramine HCl as compared to temazepam, zopiclone, lorazepam, and oxazepam. Illness intrusiveness was significantly higher among patients taking amitriptyline as compared to those taking triazolam, oxazepam, long-acting benzodiazepines, and zopiclone. It may be useful to inform patients of differences in psychosocial outcomes when prescribing hypnotic medications.

Keywords

sleepquality of lifeillness intrusivenesspharmacotherapyhypnotic medications
Type
Research Article
Information
European Psychiatry , Volume 10 , Issue S3: Satellite Symposium to the AEP Congress , 1995 , pp. 153s - 159s
Copyright
Copyright © Elsevier, Paris 1995

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