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Did the effect of placebo increase in rcts of panic disorder across the years?

Published online by Cambridge University Press:  13 August 2021

F. Di Segni ,
T. Zoppi ,
F. Forcina ,
G. Anibaldi ,
P. Bargagna ,
C.L. Telesforo ,
F. Montebovi ,
G. Callovini ,
G. Giuseppin  and
D. Janiri
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F. Di Segni
Affiliation:
Nesmos Department (neurosciences, Mental Healt And Sensory Functions), Sant’andrea Hospital, “Sapienza” University of Rome, Rome, Italy
T. Zoppi
Affiliation:
Nesmos Department (neurosciences, Mental Healt And Sensory Functions), Sant’andrea Hospital, “Sapienza” University of Rome, Rome, Italy
F. Forcina
Affiliation:
Nesmos Department (neurosciences, Mental Healt And Sensory Functions), Sant’andrea Hospital, “Sapienza” University of Rome, Rome, Italy
G. Anibaldi
Affiliation:
Nesmos Department (neurosciences, Mental Healt And Sensory Functions), Sant’andrea Hospital, “Sapienza” University of Rome, Rome, Italy
P. Bargagna
Affiliation:
Nesmos Department (neurosciences, Mental Healt And Sensory Functions), Sant’andrea Hospital, “Sapienza” University of Rome, Rome, Italy
C.L. Telesforo
Affiliation:
Psychiatry, ASL Roma 1, Rome, Italy
F. Montebovi
Affiliation:
Psychiatry, ASL Latina, Latina, Italy
G. Callovini
Affiliation:
Psychiatry, ASL Rieti, Rieti, Italy
G. Giuseppin
Affiliation:
Ageing, Neurosciences, Head-neck And Orthopaedics Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
D. Janiri
Affiliation:
Psychiatry, Sapienza University, Rome, Italy
M. Molinaro
Affiliation:
Department Of Neuroscience, Section Of Psychiatry, Università Cattolica del Sacro Cuore, Rome, Italy
G. Sani
Affiliation:
Ageing, Neurosciences, Head-neck And Orthopaedics Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
G.D. Kotzalidis*
Affiliation:
Psychiatry, Sapienza University, Rome, Italy
*
*Corresponding author.

Abstract

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Introduction

The curious effect of an increase of the placebo effect across year of publication has been shown for depression, schizophrenia, obsessive-compulsive disorder, as well as for some medical conditions like hypertension and pain.

Objectives

We aimed to observe how randomised clinical trials with a placebo control behave at this respect in panic disorder trials.

Methods

We searched the PubMed database using the strategy: (panic disorder OR panic attack disorder) AND placebo, which on 3 November 2020 produced 779 records. Inclusion criteria were the above stated, excluded were all studies focusing on the same patients as others and those not providing intelligible data. In our selection we used the PRISMA statement and reached agreement with Delphi rounds.

Results

We identified through other sources further 3 studies. The finally eligible studies were 82, excluded were 700 studies, mainly consisting of reviews (176), challenge studies (173), not dealing with panic disorder (67), studies with unsuitable designs to detect placebo effect (53), studies using same populations as others (36), those with misfocused outcomes (57), those lumping diagnoses and not allowing to separate data for panic disorder (22), and those not using placebo at all (21). Mean response to placebo in included panic disorder studies was 36.01±19.812, ranging from 0 to 76.19%; the correlation with year of publication was positive and significant (Pearson’s r= 0.246; p=0.026).

Conclusions

The effect of placebo in randomised control trials has increased across the years, but this field of research appears to be idle in recent years.

Disclosure

No significant relationships.

Keywords

drugspanic attackpanic disorderPlacebo
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S611 - S612
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Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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