Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-20T03:32:05.546Z Has data issue: false hasContentIssue false
  • English
  • Français

Development of alcohol-associated cues and cue-induced brain activation in alcoholics

Published online by Cambridge University Press:  16 April 2020

J. Wrase ,
S.M. Grüsser ,
S. Klein ,
C. Diener ,
D. Hermann ,
H. Flor ,
K. Mann ,
D.F. Braus  and
A. Heinz
J. Wrase*
Affiliation:
Department of Psychiatry of the Charité, Humboldt-University of Berlin, Schumannstr. 20/21, 10117 Berlin, Germany
S.M. Grüsser
Affiliation:
Department of Psychology, Clinical Psychology and Behavioral Neuroscience Unit, Humboldt-University Berlin, Germany
S. Klein
Affiliation:
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany Department of NMR-Research, Central Institute of Mental Health, Mannheim, Germany
C. Diener
Affiliation:
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
D. Hermann
Affiliation:
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
H. Flor
Affiliation:
Department of Neuropsychology, Central Institute of Mental Health, Mannheim, Germany
K. Mann
Affiliation:
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
D.F. Braus
Affiliation:
Department of NMR-Research, Central Institute of Mental Health, Mannheim, Germany
A. Heinz
Affiliation:
Department of Psychiatry of the Charité, Humboldt-University of Berlin, Schumannstr. 20/21, 10117 Berlin, Germany
*
*Corresponding author. E-mail address:[email protected] (J. Wrase).
Get access

Summary

The objective of this study was to develop new standardized alcohol-associated cues and assess their effects on brain activation with functional magnetic resonance imaging (fMRI). Pictures of alcoholic and neutral beverages and affectively neutral pictures were presented to 44 abstinent alcoholics and 37 age-matched healthy control subjects. We assessed the skin conductance response, and the elicited arousal and valence. Alcoholics and control subjects did not differ in arousal, valence or skin conductance response evoked by alcohol-associated and affectively neutral stimuli, while nonalcoholic beverages were rated as more unpleasant and arousing by alcoholics compared with control subjects. In the fMRI pilot study, alcohol and abstract pictures were presented to six abstinent alcoholics and induced a significant activation of brain areas associated with visual emotional processes such as the fusiform gyrus, parts of the brain reward system (basal ganglia and orbitofrontal gyrus) and further brain regions in the frontal and parietal cortices associated with the attention network. These observations suggest that standardized pictures of alcoholic beverages can be used to assess brain circuits involved in the processing and evaluation of alcohol cues.

Keywords

Cue reactivityStandardized alcohol cuesSAMEDAfMRI
Type
Short communication
Information
European Psychiatry , Volume 17 , Issue 5 , September 2002 , pp. 287 - 291
Copyright
Copyright © European Psychiatric Association 2002

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Böning, J. Evidence for the existence of an “addiction memory” – clinical empiricism and neurobiological arguments. Sucht 1994;40:244–52.Google Scholar
Bradley, JDLang, P. Measuring emotion: the self-assessment manikin and the semantic differential. J Behav Ther Exp Psychiatry 1994;25:49–59.CrossRefGoogle ScholarPubMed
Braus, DFWrase, JGrüsser, SMHermann, DRuf, MFlor, HMann, KHeinz, A. Alcohol-associated stimuli activate the ventral striatum in abstinent alcoholics. J Neural Transm 2001;108:887–94.Google ScholarPubMed
Bush, GVogt, BAHolmes, JDale, AMGreve, DJenike, MARosen, BR. Dorsal anterior cingulate cortex: a role in reward-based decision making. Proc Natl Acad Sci USA 2002;99:523–8.Google ScholarPubMed
Di Chiara, G. The role of dopamine in drug abuse viewed from the perspective of its role in motivation. Drug Alc Dependence 1995;38:95–137.CrossRefGoogle ScholarPubMed
Drevets, WCGautier, CHPrice, JCKupfer, DJKinahan, PEGrace, AA. PET measures of amphetamine-induced dopamine release in human ventral striatum correlate with euphoria. Soc Neurosci Abs 2000;26:1073.Google Scholar
Fähndrich, EStieglitz, RD. Das AMPD System. Manual zur Dokumentation psychiatrischer Befunde. 6. Edition. Hogrefe: Göttingen, Bern, Toronto, Seattle; 1997.Google Scholar
Friston, KJHolmes, APPoline, JBGrasby, PJWilliams, SCFrackowiak, RSTurner, R. Analysis of fMRI time-series revisited. Neuroimage 1995;2:45–53.CrossRefGoogle ScholarPubMed
Garavan, HPankiewicz, JBloom, ACho, JKSperry, LRoss, TJSalmeron, BJRisinger, RKelley, DStein, EA. Cueinduced cocaine craving: neuroanatomical specificity for drug users and drug stimuli. Am J Psychiatry 2000;57:1789–98.CrossRefGoogle Scholar
Heinz, ADufeu, PKuhn, SDettling, MGraef, KJKuerten, IRommelspacher, HSchmidt, LG. Psychopathological and behavioral correlates of dopaminergic sensitivity in alcohol-dependent patients. Arch Gen Psychiatry 1996;53:1123–8.CrossRefGoogle ScholarPubMed
Lang, PJÖhman, AVaitl, D. The International Affective Picture System (photographic slides). Gainsville: Center for Research in Psychophysiology, University of Florida 1988.Google Scholar
Lang, PJBradely, MMFitzsimmons, JRCuthbert, BNScott, JDMoulder, BNangia, V. Emotional arousal and activation of the visual cortex: an fMRI analysis. Psychophysiology 1998;35:199–210.CrossRefGoogle ScholarPubMed
Maas, LCLukas, SEKaufman, MJWeiss, RDDaniels, SLRogers, VWKukes, TJRenshaw, PF. Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving. Am J Psychiatry 1998;155:124–6.CrossRefGoogle ScholarPubMed
Robinson, TEBerridge, KC. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Rev 1993;18:247–91.CrossRefGoogle Scholar
Sass, HSoyka, MMann, KZieglgänsberger, W. Relapse prevention by acamprosate: results from a placebo-controlled study on alcohol dependence. Arch Genl Psychiatry 1996;53:673–80.CrossRefGoogle Scholar
Schultz, WTremblay, LHollerman, . Reward prediction in primate basal ganglia and frontal cortex. Neuropharmacology 1998;37:421–9.CrossRefGoogle ScholarPubMed
Siegel, SAllen, LG. Learning and homeostasis: drug addiction and the McCullogh effect. Psychol Bull 1998;124:230–9.Google Scholar
Stewart, JdeWit, HEickelboom, R. The role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants. Psychol Rev 1984;91:251–68.CrossRefGoogle ScholarPubMed
Tzschenke, TM. Pharmacology and behavioral pharmacology of the mesocortical dopamine system. Prog Neurobiol 2001;63:241–320.CrossRefGoogle Scholar
Volkow, NDWang, GJFischman, MWFoltin, RWFowler, JSAbumrad, NNVitkun, SLogan, JGatley, SJPappas, NHitzeman, RShea, CE. Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature 1997;386:827–30.CrossRefGoogle ScholarPubMed
Volpicelli, JRWatson, NTKing, ACSherman, CEO’Brien, CP. Effect of naltrexone on alcohol “high” in alcoholics. Am J Psychiatry 1995;152:613–5.Google Scholar
Wexler, BEGottschalk, CHFulbright, RKProhovnik, ILacadie, CMRounsaville, BJGore, JC. Functional magnetic resonance imaging of cocaine craving. Am J Psychiatry 2001;158:86–95.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.