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Depression in multiple sclerosis: RS-FMRI research

Published online by Cambridge University Press:  13 August 2021

A. Temniy ,
K. Markin ,
M. Poplyak ,
A. Trufanov ,
D. Tarumov  and
I. Litvinenko
A. Temniy*
Affiliation:
Psychiatry, S.M.Kirov Military Medical Academy, Saint-Petersburg, Russian Federation
K. Markin
Affiliation:
Psychiatry, S.M.Kirov Military Medical Academy, Saint-Petersburg, Russian Federation
M. Poplyak
Affiliation:
Neurology, S.M.Kirov Military Medical Academy, Saint-Petersburg, Russian Federation
A. Trufanov
Affiliation:
Neurology, S.M.Kirov Military Medical Academy, Saint-Petersburg, Russian Federation
D. Tarumov
Affiliation:
Psychiatry, S.M.Kirov Military Medical Academy, Saint-Petersburg, Russian Federation
I. Litvinenko
Affiliation:
Neurology, S.M.Kirov Military Medical Academy, Saint-Petersburg, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Multiple sclerosis (MS) is a demyelinating and neurodegenerative disorder of the CNS, which incapacitates people of working age. Due to progressive disability, the quality of life decreases, adding a number of other diseases to the main one. Several studies have reported high rates of depression in MS with a lifetime prevalence of approximately 50%.

Objectives

Therefore, we would like to pattern the functional activation of the brain of patients with different phenotypes of MS. This would objectify the patient’s condition and the effectiveness of therapy for these diseases.

Methods

68 patients with MS were examined: 40 with a relapsing-remitting type of course (RRMS) in remission and 28 with secondary - progressive MS (SPMS). Patients underwent MRI of the brain on a Siemens Tim Trio 3.0 T tomograph and processed the data using CONN 18b software. Clinical features were estimated by tests (BDI, HADS) results.

Results

91% of all MS patients in research have signs of depression. We noted that decreased FC in RRMS patients has a whole-brain type, but it is only decreasing, not losing the connections between brain clusters. Decreased FC and losing the connections between large-scale brain networks and brain clusters. Due to tests, more severe depression was observed in SPMS patients.

Conclusions

Our findings suggest that patients with SPMS have depression, cause of decreasing in FC between the main clusters of the brain, and patients with SPMS have more severe depression, which, as we assume, neurodegeneration has turned into atrophy and loosing all connections between clusters even in large-scale brain networks.

Disclosure

No significant relationships.

Keywords

Multiple sclerosisDepressionrs-fMRIcomorbidity
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S90
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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