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Delusional ideation, manic symptomatology and working memory in a cohort at clinical high-risk for psychosis: A longitudinal study

Published online by Cambridge University Press:  15 April 2020

M.R. Broome ,
F. Day ,
I. Valli ,
L. Valmaggia ,
L.C. Johns ,
O. Howes ,
P. Garety  and
P.K. McGuire
M.R. Broome*
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, United Kingdom Health Sciences Research Institute, Warwick Medical School, University of Warwick, Gibbet Hill, Coventry, CV4 7AL, United Kingdom
F. Day
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, United Kingdom
I. Valli
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, United Kingdom
L. Valmaggia
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, United Kingdom
L.C. Johns
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, United Kingdom Department of Psychology, Institute of Psychiatry, King's College London, De Crespigny Park, SE5 8AF, London, United Kingdom
O. Howes
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, United Kingdom
P. Garety
Affiliation:
Department of Psychology, Institute of Psychiatry, King's College London, De Crespigny Park, SE5 8AF, London, United Kingdom
P.K. McGuire
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, United Kingdom
*
*Corresponding author. E-mail address: [email protected] (M.R. Broome).
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Abstract

We followed up a cohort (n = 35) of clients with an “At Risk Mental State” (ARMS) for almost 2 years (mean 21.3 months). At baseline, these clients had taken part in research looking at the relationship between reasoning biases, memory, personality styles and delusional ideation. During the follow-up period, clients underwent a package of intervention from a specialist early detection team. Eighty percent (n = 28) of these clients were successfully re-interviewed. There was improvement across the cohort as a whole, however five participants (17.9%) had made the transition to psychosis at follow-up. Those who had become psychotic had lower levels of manic symptomatology at baseline than those who did not enter the first episode. Further, across the cohort, impaired working memory and delusional ideation at baseline combined to predict 45% of the delusional ideation at follow-up. These preliminary findings suggest that working memory impairments may be linked to the persistence of delusional ideation and that manic symptoms in someone with an ARMS may suggest that such an individual is less likely to develop a frank psychotic episode.

Keywords

DelusionsProdromalMemoryManiaPsychosisHigh-risk
Type
Original articles
Information
European Psychiatry , Volume 27 , Issue 4 , May 2012 , pp. 258 - 263
Copyright
Copyright © Elsevier Masson SAS 2012

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