Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-29T22:57:53.687Z Has data issue: false hasContentIssue false
  • English
  • Français

the Deleterious Effect of Cognitive Impairment, Negative Symptoms and Functional Disability on Quality of Life in Chronic Schizophrenia

Published online by Cambridge University Press:  16 April 2020

E. Elizagárate ,
P. Sánchez ,
A.B. Yoller ,
J. Peña ,
N. Ojeda ,
J. Larumbe ,
M. Gutiérrez  and
J. Ezcurra
E. Elizagárate
Affiliation:
Treatment-resistant Psychosis Unit, Hospital Psiquiátrico de Álava-Osakidetza, Vitoria, Spain Department of Neurosciencies, Faculty of Medicine, University of the Basque Country, Vitoria, Spain
P. Sánchez
Affiliation:
Treatment-resistant Psychosis Unit, Hospital Psiquiátrico de Álava-Osakidetza, Vitoria, Spain
A.B. Yoller
Affiliation:
Treatment-resistant Psychosis Unit, Hospital Psiquiátrico de Álava-Osakidetza, Vitoria, Spain
J. Peña
Affiliation:
Department of Psychology, University of Deusto, Bilbao, Spain
N. Ojeda
Affiliation:
Department of Psychology, University of Deusto, Bilbao, Spain
J. Larumbe
Affiliation:
Treatment-resistant Psychosis Unit, Hospital Psiquiátrico de Álava-Osakidetza, Vitoria, Spain
M. Gutiérrez
Affiliation:
Department of Neurosciencies, Faculty of Medicine, University of the Basque Country, Vitoria, Spain Department of Psychiatry, Hospital Santiago Apóstol - Osakidetza, Vitoria, Spain CIBERSAM, Spanish Ministry of Health, Instituto de Salud Carlos III, Madrid, Spain
J. Ezcurra
Affiliation:
Treatment-resistant Psychosis Unit, Hospital Psiquiátrico de Álava-Osakidetza, Vitoria, Spain

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Aims:

To examine the relative contributions of psychiatric symptoms, functional disability, neuropsychological functioning and sociodemographic variables to quality of life (QOL) in patients with chronic schizophrenia.

Method:

We examined 165 hospitalised patients with long term schizophrenia (DSM-IV). Measures of psychiatric symptoms included depression (Calgary depression Scale), insight (David Insight Scale), symptom severity (BPRS) and PANSS (Positive and Negative Symptom Scale). Neuropsychological battery included tests for verbal memory, executive functioning, verbal fluency, working memory, motor speed and processing speed. Functional disability was assessed with the Disability Assessment Schedule (DAS-WHO) and Quality of life was assessed with the Quality of Life Scale.

Results:

Age, years of evolution, negative symptoms, insight and neuropsychological variables (except motor speed) all were significantly related to level of quality of life. in a multiple regression analysis, entering the neuropsychological functioning, functional disability and negative symptoms generated a model which accounted for a 74.9% of the variance in QOL. Functional disability, as expected, accounted for 56% of the variance, whereas Processing Speed explained an additional 6.2%. Symptom Severity and Verbal Fluency predicted 3.7% and 3.5% of the variance, respectively. Negative symptoms, Verbal Memory and Vocabulary, were also significant predictors in the model, but had less predictive value. However, Positive Symptoms and Sociodemographic Variables did not significantly contribute to predict quality of life.

Conclusion:

Our findings support the predictive value of neuropsychological functioning, functional disability and severity of negative symptoms in long term quality of life in schizophrenia.

Type
P03-193
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E1192
Copyright
Copyright © European Psychiatric Association 2009
Submit a response

Comments

No Comments have been published for this article.