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Deficient Multisensory Integration with concomitant resting-state connectivity in adult ADHD

Published online by Cambridge University Press:  01 September 2022

M. Schulze ,
B. Aslan ,
S. Lux  and
A. Philipsen
M. Schulze*
Affiliation:
University Clinic Bonn, Dpeartment For Psychiatry And Psychotherapy, Bonn, Germany
B. Aslan
Affiliation:
University Clinic Bonn, Dpeartment For Psychiatry And Psychotherapy, Bonn, Germany
S. Lux
Affiliation:
University Clinic Bonn, Dpeartment For Psychiatry And Psychotherapy, Bonn, Germany
A. Philipsen
Affiliation:
University of Bonn, Psychiatry, Bonn, Germany
*
*Corresponding author.

Abstract

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Introduction

ADHD patients often report that they are being flooded by sensory impressions. Studies investigating sensory processing show hypersensitivity for sensory inputs across the senses. While studying unimodal signal-processing is relevant and well-suited in a controlled laboratory environment, our daily interaction with our environment does not occur merely unimodal. A complex interplay of the senses is necessary to form a unified percept. In order to achieve this, the unimodal sensory modalities are bound together in a process called multisensory integration (MI).

Objectives

In the current study we investigate MI in an adult ADHD sample accompanied by resting-state functional magnetic resonance imaging (RS-fMRI).

Methods

Twenty-five ADHD patients and twenty-four healthy controls were recruited. MI was examined using the McGurk effect, where - in case of successful MI - incongruent speech-like phonemes between visual and auditory modality are leading to a perception of a new phoneme. Mann-Whitney-U test was applied to assess statistical differences between groups. Resting-state functional MRI was acquired to realize a seed-to-voxel analysis

Results

Susceptibility to MCGurk was significantly lowered for ADHD patients (ADHDMdn:5.83%, ControlsMdn:44.2%, U= 160.5, p=0.022, r=-0.34). When ADHD patients integrated phonemes, reaction times were significantly longer (ADHDMdn:1260ms, ControlsMdn:582ms, U=41.0, p<.000, r= -0.56). Seeded medio temporal gyrus was negatively associated in functional connectivity to primary auditory cortex, inferior frontal gyrus, precentral gyrus, and fusiform gyrus.

Conclusions

MI seems to be deficient for ADHD patients for stimuli that need late attentional allocation. This finding is supported for higher functional connectivity from unimodal sensory areas to polymodal, MI convergence zones for complex stimuli.

Disclosure

No significant relationships.

Keywords

adult ADHDResting-state fMRTmultisensory Inegration
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S332
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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