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Decreased frontal activation in schizophrenics during stimulation with the Continuous Performance Test - a functional magnetic resonance imaging study

Published online by Cambridge University Press:  16 April 2020

H.-P. Volz ,
C. Gaser ,
F. Häger ,
R. Rzanny ,
J. Pönisch ,
H.-J. Mentzel ,
W.A. Kaiser  and
H. Sauer
H.-P. Volz
Affiliation:
Department of Psychiatry
C. Gaser
Affiliation:
Department of Psychiatry
F. Häger
Affiliation:
Department of Psychiatry
R. Rzanny
Affiliation:
Institute of Diagnostical and Interventional Radiology (IDIR), Friedrich-Schiller-University Jena, Germany
J. Pönisch
Affiliation:
Department of Psychiatry
H.-J. Mentzel
Affiliation:
Institute of Diagnostical and Interventional Radiology (IDIR), Friedrich-Schiller-University Jena, Germany
W.A. Kaiser
Affiliation:
Institute of Diagnostical and Interventional Radiology (IDIR), Friedrich-Schiller-University Jena, Germany
H. Sauer
Affiliation:
Department of Psychiatry
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Summary

The Continuous Performance Test (CPT) has become an essential constituent of the neuropsychological investigation of schizophrenia. Also, a vast number of brain imaging studies, mostly PET investigations, have employed the CPT as a cognitive challenge and established a relative hypofrontality in schizophrenics compared to controls. The aim of the present investigation was to clarify whether this predescribed hypofrontality could also be verified using functional magnetic resonance imaging (fMRI). 20 healthy volunteers and 14 schizophrenics on stable neuroleptic medication were included. Imaging was performed using the CPT-double-T-version and a clinical 1.5 T MRI-scanner with a single slice technique and a T2*-weighted gradient-echo-sequence. The schizophrenics exhibited a decreased activation in the right mesial prefrontal cortex, the right cingulate and the left thalamus compared to controls. These results obtained by fMRI are discussed in relation to published findings using PET.

Keywords

functional magnetic resonance imagingschizophreniaattentionhypofrontality
Type
Research Article
Information
European Psychiatry , Volume 14 , Issue 1 , March 1999 , pp. 17 - 24
Copyright
Copyright © Elsevier, Paris 1999

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References

American Psychiatric, Association. Diagnostic and statistical manual of mental disorders. Third Edition, revised. Washington: American Psychiatric Press; 1987.Google Scholar
Andreasen, N. The scale for the assessment of negative symptoms (SANS). Iowa: The University of Iowa; 1983.Google Scholar
Andreasen, N. The scale for the assessment of positive symptoms (SAPS). Iowa: The University of Iowa; 1984.Google Scholar
Andreasen, NCRezai, KSwayze, VWIi Flau, MKirchne, PCohen, G. et alHypofrontality in neuroleptic naive patients and in patients with chronic schizophrenia. Assessment with xenon single-photon emission computed tomography and the Tower of London Arch Gen Psychiatry 1992; 49 : 943–958.CrossRefGoogle ScholarPubMed
Barch, DMBraver, TSNystom, LCarter, CSNoll, DCCohen, J. Activation of prefrontal cortex by context processing Biol Psychiatry 1997; 41 : 85S–85S.Google Scholar
Barnes, TR. Tardive dyskinesia: Risk factors, pathophysiology and treatment. In: Granville—Grossman, k, Ed. Recent advances in clinical psychiatry, number six. London: Churchill Livingstone 1988 195–205.Google Scholar
Berman, KIllowsky, BWeinberger, D. Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. IV. Further evidence for regional and behavioral specifity. Arch Gen Psychiatry 1988; 45 : 616–622.CrossRefGoogle Scholar
Berman, KZec, RWeinberger, D. Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. II: Role of neuroleptic treatment, attention and mental effort Arch Gen Psychiatry 1986; 43 : 125–135.CrossRefGoogle Scholar
Braver, TCohen, JNystrom, LJonides, JSmith, ENoll, D. A parametric study of prefrontal cortex involvement in human working memory Neuroimage 1997; 5 : 49–62.CrossRefGoogle ScholarPubMed
Buchsbaum, M. The frontal lobes, basal ganglia, and temporal lobes as sites for schizophrenia Schizophr Bull 1990; 16 : 379–389.CrossRefGoogle Scholar
Buchsbaum, MSHaier, RPotkin, SNuechterlein, KBracha, HSKatz, M. Frontostriatal disorder of cerebral metabolism in never-medicated schizophrenics Arch Gen Psychiatry 1992a; 49 : 935–942.CrossRefGoogle Scholar
Buchsbaum, MSNuechterlein, KNHaier, RJWu, JSicotte, NHazlett, E. Glucose metabolic rate in normals and schizophrenics during the Continuous Performance Test assessed by positron emission tomography Brit J Psychiatry 1990; 156 : 216–227.CrossRefGoogle ScholarPubMed
Buchsbaum, MSPotkin, SGSiegel, BV JrLohr, JKatz, MGottschalk, LA. Striatal metabolic rate and clinical response to neuroleptics in schizophrenia Arch Gen Psychiatry 1992b; 49 : 966–974.CrossRefGoogle Scholar
Buchsbaum, MSSomeya, TTeng, CYAbel, LChin, SNajafi, A. PET and MRI of the thalamus in never medicated patients with schizophrenia Am J Psychiatry 1996; 153 : 191–199.Google ScholarPubMed
Cleghorn, JMGarnett, ESNahmias, CFirman, GBrown, GMKaplan, RD. Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia Psychiatry Res 1989; 28 : 119–133.CrossRefGoogle ScholarPubMed
Cohen, JDForman, SDBraver, TSCasey, BJServan-Schreiber, DNoll, DC. Activation of the prefrontal cortex in a nonspatial working memory task with functional MRI Human Brain Mapping 1994; 1 : 293–304.CrossRefGoogle Scholar
Cohen, RMNordahl, TESemple, WEAndreason, PLitman, REPickar, D. The brain metabolic patterns of clozapine- and fluphenazine-treated patients with schizophrenia during a continuous performance task Arch Gen Psychiatry 1997; 54 : 481–486.CrossRefGoogle ScholarPubMed
Cohen, RMSemple, WEGross, MNordahl, TEDelisi, LEHolcomb, HH. Dysfunction in a prefrontal substrate of sustained attention in schizophrenia Life Sciences 1987; 40 : 2031–2039.CrossRefGoogle Scholar
Cohen, RMSemple, WEGross, MNordahl, TEHolcomb, HHDowling, M.S. The effect of neuroleptics on dysfunction in a prefrontal substrate of sustained attention in schizophrenia Life Sciences 1988; 43 : 1141–1150.CrossRefGoogle Scholar
Egan, JP. New York: Academic Press; 1980.Google Scholar
Friston, KJAshburner, JFrith, CDPoline, JPHeather, JBFrackowiak, RSJ. Spatial registration and normalization of images Human Brain Mapping 1995a; 2 : 165–189.CrossRefGoogle Scholar
Friston, KJHolmes, APWorsley, KJPoline, JPFrith, CDFrackowiak, RSJ. Statistical parametric maps in functional imaging: A general linear approach Human Brain Mapping 1995b; 2 : 189–210.CrossRefGoogle Scholar
Friston, KJWorsley, KJFrackowiak, RSJMaziotta, JCEvans, AC. Assessing the significance of focal activations using their spatial extent Human Brain Mapping 1994; 1 : 214–220.CrossRefGoogle ScholarPubMed
Grier, JB. Non parametric indices for sensitivity and bias: computing formulas Psychol Bull 1971; 75 : 424–429.CrossRefGoogle Scholar
Häger, FVolz, HPGaser, CMentzel, HJKaiser, WASauer, H. Challenging the anterior attentional system with a continuous performance task - a functional magnetic resonance imaging approach Eur Arch Neurol Psychiatry in press 1998;Google ScholarPubMed
Himke, RMHu, XStillman, AEKim, SEMerkle, HSalmi, R. Functional magnetic resonance imaging of Brocás area during internal speech NeuroReport 1993; 4 : 675–678.CrossRefGoogle Scholar
Ingvar, DHFranzen, G. Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia Acta Psychiatr Scand 1974; 50 : 425–462.CrossRefGoogle ScholarPubMed
Jones, PMurray, RM. The genetics of schizophrenia is the genetics of neurodevelopment Brit J Psychiatry 1991; 158 : 615–623.CrossRefGoogle ScholarPubMed
Katz, MBuchsbaum, MSSiegel, BVWu, JHaier, RJBunney, WE. Correlational patterns of central glucose metabolism in never medicated schizophrenics Neuropsychobiol 1996; 33 : 1–11.CrossRefGoogle Scholar
Marenco, SCoppola, RDaniel, DGZigun, JRWeinberger, DR. Regional cerebral blood flow during the Wisconsin Card Sorting Test in normal subjects studied by Xenon-133 dynamic SPECT: Comparison of absolute values, percent distribution values, and covariance analysis Psychiatry Res Neuroimag 1993; 50 : 177–192.CrossRefGoogle ScholarPubMed
Mesulam, MM. A cortical network for directed attention and unilateral neglect Ann Neurol 1981; 10 : 309–325.CrossRefGoogle ScholarPubMed
National Institutes Of Mental Health 112 - CGI. Clinical Global ImpressionsIn: Guy, WBonato, RR, Eds. Manual for the ECSEU Assessment Battery Chevy Chase: NIH; 1979, pp. 12–16.Google Scholar
Neurosoft, INCEgan, JP. New York: Academic Press; 1990Google Scholar
Nuechterlein, KH. Vigilance in schizophrenia and related disordersIn: Steinhauer, SGruzelier, JHZubin, J, Eds. Handbook of schizophrenia Amsterdam: Elsevier 1991 397–433.Google Scholar
Nuechterlein, KHDawson, ME. Information processing and attentional functioning in the developmental course of schizophrenic disorders Schizophr Bull 1984; 10 : 160–203.CrossRefGoogle ScholarPubMed
Oldfield, RC. The assessment and analysis of handedness: The Edinburgh Inventory Neuropsychologia 1971; 9 : 97–113.CrossRefGoogle ScholarPubMed
Overall, JEGorham, DR. The Brief Psychiatric Rating Scale Psychol Rep 1962; 10 : 799–812.CrossRefGoogle Scholar
Pantalis, CBarnes, TRENelson, HE. A pilot study of subcortical dementia in schizophrenia [Abstract] Schizophr Res 1989; 2 : 69.CrossRefGoogle Scholar
Pantalis, CBarnes, TRENelson, HE. Is the concept of frontal-subcortical dementia relevant to schizophrenia? Brit J Psychiatry 1992; 160 : 442–460.CrossRefGoogle Scholar
Pantalis, CNelson, HE. Cognitive functioning and symptomatology in schizophrenia: The role of frontal-subcortical systemsIn: David, ASCutting, JCThe neuropsychology of schizophrenia Hove: Lawrence Earlbaum; 1994. p. 215–229.Google Scholar
Raven JCAdvances progressive Matrices, sets I, and II. Plan and use of the scale with a report of experimental work. London: Lewis HK, 1965.Google Scholar
Rosvold, HEMirsky, AFSarason, IBransome, ED JrBeck, LH. A continuous performance test of brain damage J Consult Clin Psychol 1956; 20 : 343–350.CrossRefGoogle Scholar
Schröder, JBuchsbaum, MSSiegel, BVGeider, FJHaier, RJLohr, J. Patterns of cortical activity in schizophrenia Psychol Med 1994; 24 : 947–955.CrossRefGoogle Scholar
Schröder, JBuchsbaum, MSSiegel, BVGeider, FJLohr, JTang, C. Cerebral metabolic activity correlates of subsyndromes in chronic schizophrenia Schizophrenia Res 1996; 19 : 41–53.CrossRefGoogle ScholarPubMed
Siegel, BJ JrBuchsbaum, MSBunney, W.EGottschalk, L.AHaier, RJLohr, JB. Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients Am J Psychiatry 1993; 150 : 1325–1336.Google ScholarPubMed
Siegel, BV JrNuechterlein, KHAbel, LWu, JCBuchsbaum, MS. Glucose metabolic correlates of continuous performance test performance in adults with a history of infantile autism, schizophrenics and controls Schizophr Res 1995; 17 : 85–94.CrossRefGoogle ScholarPubMed
Talairach, JTournoux, P. Co-planar stereotaxic atlas of the human brain Stuttgart: Thieme; 1988.Google Scholar
van den Bosch, RJ. Context and cognition in schizophreniaIn: Van Den Boer, JAWestenberg, HGMVan Praag, HM Eds. Advances in the neurobiology of schizophrenia Chichester: Wiley; 1995. p. 343–366.Google Scholar
Volz, HPGaser, CHäger, FRzanny, RMentzel, HJKreitschmann-Andermahr, I. Brain activation during cognitive stimulation with the Wisconsin Card Sorting Test - a functional MRI study on healthy volunteers and schizophrenics Psychiatry Res Neuroimag 1997; 75 : 145–157.CrossRefGoogle Scholar
Weinberger, DR. Implications of normal brain development for the pathogenesis of schizophrenia Arch Gen Psychiatry 1987; 44 : 660–669.CrossRefGoogle ScholarPubMed
Woods, SW. Regional cerebral blood flow imaging with SPECT in psychiatric disease: Focus on schizophrenia, anxiety disorders, and substance abuse J Clin Psychiatry 1992; 53 suppl : 20–25.Google ScholarPubMed
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