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Decrease in brain complexity with methylphenidate treatment in boys diagnosed with attention deficit hyperactivity disorder: An entropy-based qeeg analysis

Published online by Cambridge University Press:  13 August 2021

F.H. Çetin ,
M.B. Usta ,
S. Aydın  and
A.S. Güven
F.H. Çetin*
Affiliation:
Child And Adolescent Psychiatry, Selçuk University, Faculty of Medicine, Konya, Turkey
M.B. Usta
Affiliation:
Child And Adolescent Psychiatry, Ondokuz Mayıs University, Faculty of Medicine, Samsun, Turkey
S. Aydın
Affiliation:
Biophysics Department, Hacettepe University Medical Faculty, Ankara, Turkey
A.S. Güven
Affiliation:
Pediatric Neurology, Necmettin Erbakan Univesity, Meram Faculty of Medicine, Konya, Turkey
*
*Corresponding author.

Abstract

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Introduction

Attention deficit hyperactivity (ADHD) disorder is a common childhood neurodevelopmental disorder, and Methylphenidate (MPH) is a first-line therapeutic option for treating ADHD.However, how brain complexity and entropy changes with methylphenidate treatment the clinical implications of possible changes in entropy and the clinical implications of possible changes in entropy have yet to be studied.

Objectives

This study aimed to reveal how the MPH treatment affects the complexity in the brain of children with ADHD by entropy-based qEEG analysis. In addition, the presence of the relationship between possible neurophysiological changes to be detected with clinical variables and how they are two other important questions of this study to be answered.

Methods

During eyes-open resting, EEG signals were recorded from 25 boys with ADHD-combined type before MPH administration and at the end of the 1st month of the treatment. Approximate entropy (ApEn), sample entropy (SampEn), permutation entropy (PermEn) were used to analyse.

Results

A statistically significant decrease in entropy level was found with MPH treatment in the F4 channel according to approximate entropy (ApEn) and sample entropy (SampEn) analysis (p<0.05). In addition, according to permutation entropy (PermEn) analysis, the decrease in entropy with MPH treatment in the regions indicated by F3, F4, P4, T3, T6, and O2 channels was found to be statistically significant (p <0.05).

Conclusions

This is the first study to investigate how MPH treatment affects the complexity in the brain of children with ADHD. Entropy-based qEEG analysis may be a new method that can be used in diagnostic, clinical and prognostic predictions in ADHD.

Disclosure

No significant relationships.

Keywords

ADHDmethylphenidateentropycomplexity
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S633 - S634
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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