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D2 dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence

Published online by Cambridge University Press:  16 April 2020

J.P. Connor ,
R.McD. Young ,
B.R. Lawford ,
T.L. Ritchie  and
E.P. Noble
J.P. Connor
Affiliation:
Department of Psychiatry, University of Queensland, Australia
R.McD. Young
Affiliation:
Department of Psychiatry, University of Queensland, Australia
B.R. Lawford
Affiliation:
Department of Psychiatry, University of Queensland, Australia Hospital Alcohol and Drugs Service, Royal Brisbane Hospital, Brisbane, Queensland, Australia
T.L. Ritchie
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
E.P. Noble*
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
*
*Correspondence and reprints: UCLA Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024-1759, USA. E-mail address: [email protected] (E.P. Noble).
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Summary

The A1 allele of the D2 dopamine receptor (DRD2) gene has been associated with alcohol dependence. However, the expression of this allele risk on the severity of drinking behavior in patients with alcohol dependence has not been systematically explored. The present study examines the association between DRD2 A1+(A1/A1 and A1/A2 genotypes) and A1– (A2/A2 genotype) allele status and key drinking parameters in alcohol-dependent patients. A sample of Caucasian adults was recruited from an alcohol detoxification unit. A clinical interview and the Alcohol Dependence Scale (ADS) questionnaire provided data on consumption, dependence, chronology of drinking and prior detoxification. A1+ allele compared to A1– allele patients consumed higher quantities of alcohol, commenced problem drinking at an earlier age, experienced a shorter latency between first introduction to alcohol to the onset of problem drinking and had higher ADS scores. Moreover, A1+ allele patients had more detoxification attempts than their A1– allele counterparts. In sum, alcohol-dependent patients with the DRD2 A1 allele compared to patients without this allele are characterized by greater severity of their disorder across a range of problem drinking indices. The implications of these findings are discussed.

Keywords

alcohol dependenceD2 dopamine receptor (DRD2) genedrinking severitypolymorphismtreatment utilization
Type
Original article
Information
European Psychiatry , Volume 17 , Issue 1 , March 2002 , pp. 17 - 23
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS. 2002

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References

Arinami, TItokawa, MKomiyama, TMitsushio, HMori, HMifune, Het al. Association between severity of alcoholism and the A1 allele of the dopamine D2 receptor gene TaqI A RFLP in Japanese. Biol Psychiatry 1993; 33; 108–14.CrossRefGoogle Scholar
Babor, TFHofmann, MDel Boca, FKHesselbrock, VMeyer, REDolinsky, ZSet al. Types of alcoholics: I. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry 1992; 49; 599–608.CrossRefGoogle ScholarPubMed
Berman, SMNoble, EPD2 dopamine receptor (DRD2) gene and family stress; interactive effects on cognitive functioning. Behav Genet 1997; 27; 33–43.CrossRefGoogle Scholar
Blum, KNoble, EPSheridan, PJFinley, OMontgomery, ARitchie, Tet al. Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism. Alcohol 1991; 8; 409–16.CrossRefGoogle ScholarPubMed
Blum, KNoble, EPSheridan, PJMontgomery, ARitchie, TJagadeeswaran, Pet al. Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 1990; 263; 2055–60.CrossRefGoogle ScholarPubMed
Blum, KSheridan, PJWood, RCBraverman, ERChen, TJCull, JGet al. The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. J R Soc M 1996; 89; 396–400.CrossRefGoogle ScholarPubMed
Bolos, AMDean, MLucase-Derse, SRamsburg, MBrown, GLGoldman, Det al. Population and pedigree studies reveal a lack of association between the dopamine D2 receptor gene and alcoholism. JAMA 1990; 264; 3156–60.CrossRefGoogle ScholarPubMed
Cloninger, CRNeurogenetic adaptive mechanisms in alcoholism. Science 1987; 236; 410–6.CrossRefGoogle ScholarPubMed
Connor, JPWilliams, RJRicciardelli, LAGender differences in drinking restraint. J Stud Alcohol 1999; 60; 643–6.CrossRefGoogle ScholarPubMed
Connor, JPYoung, RMcDLawford, BRRitchie, TNoble, EPThe relative contribution of the A1 allele of the D2 dopamine receptor and cognitive drinking models in the prediction of problem drinking. Alcoholism 2000 ; 24 (Suppl) : 26A.Google Scholar
Connor, JPYoung, RMcDWilliams, RJRicciardelli, LADrinking restraint versus alcohol expectancies: which is the better indicator of alcohol dependence?. J Stud Alcohol 2000; 61; 352–9.CrossRefGoogle Scholar
Cook, BLWang, ZWCrowe, RRHauser, RFreimer, MAlcoholism and the D2 receptor gene. Alcohol Clin Exp Res 1992; 16; 806–9.CrossRefGoogle ScholarPubMed
Geijer, TNeiman, JRydberg, UGyllander, AJöhnson, ESedvall, Get al. Dopamine D2 receptor gene polymorphisms in Scandinavian chronic alcoholics. Eur Arch Psychiatry Clin Neurosci 1994; 244; 26–32.CrossRefGoogle ScholarPubMed
Gelernter, JGoldman, DRish, NThe A1 allele of the D2 dopamine receptor gene and alcoholism. JAMA 1993; 269; 1673–7.CrossRefGoogle ScholarPubMed
Gelernter, JO'Malley, SRisch, NKranzler, HRKrystal, JMerikangas, Ket al. No association between an allele of the D2 dopamine receptor gene (DRD2) and alcoholism. JAMA 1991; 266; 1801–7.CrossRefGoogle ScholarPubMed
Goodwin, DWSchulsinger, FHermansen, LGuze, SBWinokur, GAlcohol problems in adoptees raised apart from alcoholic biological parents. Arch Gen Psychiatry 1973; 28; 238–43.CrossRefGoogle ScholarPubMed
Gorwood, PBatel, PGouya, LCourtois, FFeingold, JAdes, JReappraisal of the association between the DRD2 gene, alcoholism and addiction. Eur Psychiatry 2000; 15; 90–6.CrossRefGoogle ScholarPubMed
Grandy, DKZhang, YCivelli, OPCR detection of the TaqA RFLP at the DRD2 locus. Hum Mol Genet 1993 ; 2 : 2197.CrossRefGoogle ScholarPubMed
Gurling, HMDCook, CCHThe genetic predisposition to alcohol dependence. Curr Opin Psychiatry 1999; 12; 269–75.CrossRefGoogle Scholar
Heather, NRobertson, IProblem drinking, 3rd ed. New York: Oxford University Press; 1997.Google Scholar
Hietala, JPohajalainen, THeikkila-Kallio, UWest, CSalaspuro, MSyvälahti, EAllelic association between D2 but not D1 dopamine receptor gene and alcoholism in Finland. Psychiatr Genet 1997; 7; 19–25.CrossRefGoogle Scholar
Jönsson, EGNöthen, MMGrünhage, FFarde, LNakashima, YPropping, Pet al. Polymorphisms in the dopamine D2 receptor gene and their relationship to striatal dopamine receptor density of healthy volunteers. Mol Psychiatry 1999; 4; 290–6.CrossRefGoogle ScholarPubMed
Kono, YYoneda, HSakai, TNonomura, YInayama, YKoh, Jet al. Association between early-onset alcoholism and the dopamine D2 receptor gene. Am J Med Genet 1997; 74; 179–82.3.0.CO;2-F>CrossRefGoogle ScholarPubMed
Lawford, BRYoung, RMcDRowell, JAQualichefski, JFletcher, BHSyndulko, Ket al. Bromocriptine in the treatment of alcoholics with the D2 dopamine receptor A1 allele. Nat M 1995; 1; 337–41.CrossRefGoogle ScholarPubMed
Lawford, BRYoung, RMcDRowell, JAGibson, JNFeeney, GFXRitchie, TLet al. Association of the D2 dopamine receptor A1 allele with alcoholism: medical severity of alcoholism and type of controls. Biol Psychiatry 1997; 41; 386–93.CrossRefGoogle ScholarPubMed
Lawford, BRYoung, RMcDNoble, EPSargent, JRowell, JShadforth, Set al. The D2 dopamine receptor A1 allele and opioid dependence: association with heroin use and response to methadone treatment. Am J Med Genet 2000; 96; 592–61.3.0.CO;2-Y>CrossRefGoogle Scholar
Noble, EPThe gene that rewards alcoholism. Sci Am Sci M 1996; 3; 52–61.Google Scholar
Noble, EPAddiction and its reward process through polymorphisms of the D2 dopamine receptor gene: A review. Eur Psychiatry 2000; 15; 79–89.CrossRefGoogle ScholarPubMed
Noble, EPBlum, KAlcoholism and the D2 receptor gene 〚letter〛. JAMA 1993 ; 270 : 1547.CrossRefGoogle Scholar
Noble, EPBlum, KRitchie, TMontgomery, ASheridan, PJAllelic association of the D2 dopamine receptor gene with receptor binding characteristics in alcoholism. Arch Gen Psychiatry 1991; 48; 648–54.CrossRefGoogle ScholarPubMed
Noble, EPSyndulko, KFitch, RJRitchie, TBohlman, MCGuth, Pet al. D2 dopamine receptor TaqI A alleles in medically ill alcoholic and nonalcoholic patients. Alcohol Alcohol 1994; 29; 729–44.Google Scholar
Parsian, ATodd, RDDevor, EJO’Malley, KLSuarez, BKReich, Tet al. Alcoholism and alleles of the human D2 dopamine receptor locus. Arch Gen Psychiatry 1991; 48; 655–63.CrossRefGoogle ScholarPubMed
Pickens, RWSvikis, DSMcGue, MLykken, DTHeston, LLClayton, PJHeterogeneity in the inheritance of alcoholism. Arch Gen Psychiatry 1991; 48; 19–28.CrossRefGoogle ScholarPubMed
Plomin, RDeFries, JCLoehlin, JCGenotype-environmental interaction and correlation in the analysis of human behavior. Psych Bull 1977; 84; 309–22.CrossRefGoogle Scholar
Plomin, ROwen, RMcGuffin, PThe genetic basis of complex behaviors. Science 1994; 264; 1733–9.CrossRefGoogle Scholar
Pohjalainen, TRinne, JONågren, KLehikoinen, PAnttila, KSyvalahti, EKGet al. The A1 allele of the human D2 dopamine receptor gene predicts low D2 dopamine receptor availability in healthy volunteers. Mol Psychiatry 1998; 3; 256–60.CrossRefGoogle ScholarPubMed
Prescott, CAAggen, SHKendler, KSSex differences in the sources of genetic liability to alcohol abuse and dependence in a population-based sample of U.S. twins. Alcohol Clin Exp Res 1999; 23; 1136–44.CrossRefGoogle Scholar
Rehm, JMeasuring quantity, frequency and volume of drinking. Alcohol Clin Exp Res 1998 ; 22 (Suppl) : 4–14.CrossRefGoogle Scholar
Ricciardelli, LAConnor, JPWilliams, RJYoung, RMcDGender stereotypes and drinking cognitions as indicators of moderate and high risk drinking among young women and men. Drug Alcohol Depend 2001; 61; 129–36.CrossRefGoogle ScholarPubMed
Skinner, HAAllen, BAAlcohol dependence syndrome: measurement and validation. J Abnorm Psychol 1982; 91; 199–209.CrossRefGoogle Scholar
Skinner, HAHorn, JLAlcohol Dependence Scale (ADS): users guide. Toronto, Ontario, Canada: Addiction Research Institute; 1984.Google Scholar
Thompson, JThomas, NSingleton, APiggott, MLloyd, SPerry, EKet al. D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics 1997; 7; 479–84.CrossRefGoogle ScholarPubMed
Turner, EEwing, JShilling, PSmith, TLIrwin, MSchuckit, Met al. Lack of association between an RFLP near the D2 dopamine receptor gene and severe alcoholism. Biol Psychiatry 1992; 31; 285–90.CrossRefGoogle ScholarPubMed
Vaillant, GEThe natural history of alcoholism. London: Harvard University Press; 1983.Google ScholarPubMed
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