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Crohn disease and schizophrenia: fortuitous association or etiopathogenic link?

Published online by Cambridge University Press:  19 July 2023

B. Zineb ,
T. Aicha ,
K. Imane ,
L. Fouad  and
O. Abderrazak
B. Zineb*
Affiliation:
Ar-razi Psychiatric hospital, Faculty of Medecine and Pharmacy, Rabat, Morocco
T. Aicha
Affiliation:
Ar-razi Psychiatric hospital, Faculty of Medecine and Pharmacy, Rabat, Morocco
K. Imane
Affiliation:
Ar-razi Psychiatric hospital, Faculty of Medecine and Pharmacy, Rabat, Morocco
L. Fouad
Affiliation:
Ar-razi Psychiatric hospital, Faculty of Medecine and Pharmacy, Rabat, Morocco
O. Abderrazak
Affiliation:
Ar-razi Psychiatric hospital, Faculty of Medecine and Pharmacy, Rabat, Morocco
*
*Corresponding author.

Abstract

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Introduction

Crohn’s disease is a chronic inflammatory bowel disease of multifactorial etiology. Its association with psychiatric disorders has frequently been reported, mainly with depressive or anxiety disorders.However, its association with schizophrenia remains exceptional.

Objectives

we will try to discuss this association.

Methods

In this regard, we report the case of a young patient, aged 24, diagnosed 5 years ago with Crohn’s disease, evolving by remission flares, currently treated with Azathioprine, after failure of corticosteroid bolus.

Results

The patient was admitted to psychiatry for aggression towards his parents.In view of the history of the disorders as reported by the family and the psychiatric interview, the diagnosis of schizophrenia was retained and the patient was put on amisulpride.

Conclusions

Schizophrenia and Crohn’s disease are relatively frequent diseases, generally occurring at a young age, whose etiopathogenesis, multifactorial, involves in both cases genetic, environmental and immunological factors.Their association does not seem fortuitous and arouses both etiopathogenic and therapeutic interest, but studies involving a large number of patients would make it possible to elucidate the link between these two diseases.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S754
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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