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Could Soluble Intercellular Adhesion Molecule-1 be Associated with State Affective Symptomatology in Healthy Adults?

Published online by Cambridge University Press:  23 March 2020

M. Pantovic ,
B. Dunjic Kostic ,
N. Petronijevic ,
M. Velimirovic ,
T. Nikolic ,
V. Jurisic ,
M. Lackovic ,
S. Totic ,
A. Jovanovic  and
A. Damjanovic
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M. Pantovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia
B. Dunjic Kostic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia
N. Petronijevic
Affiliation:
School of Medicine, Institute of Medical Biochemistry, Belgrade, Serbia
M. Velimirovic
Affiliation:
School of Medicine, Institute of Medical Biochemistry, Belgrade, Serbia
T. Nikolic
Affiliation:
School of Medicine, Institute of Medical Biochemistry, Belgrade, Serbia
V. Jurisic
Affiliation:
School of Medicine, Department of Pathophysiology, Kragujevac, Serbia
M. Lackovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia
S. Totic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia
A. Jovanovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia
A. Damjanovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia
M. Ivkovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia

Abstract

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Introduction

Immune parameters are frequently associated with mood disorders and affective temperaments. In our study, we investigate the role of soluble intercellular adhesion molecule-1 (sICAM-1) in affective temperaments and mood symptoms in healthy adults.

Methods

Healthy adults were screened for psychiatric disorders using the non-patient version of the Structured Clinical Interview for DSM-IV-I and II. Affective temperaments were evaluated with Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire (TEMPS-A). State mood symptoms were assessed using the Young Mania Rating Scale (YMRS) and Montgomery-Åsberg Depression Rating Scale (MADRS). Serum sICAM-1 levels were measured using enzyme-linked immunosorbent assay.

Results

We identified no association between sICAM-1 levels and affective temperament scores. We identified correlation between sICAM-1 levels and manic symptoms measured by YMRS. Furthermore, sICAM-1 was a significant predictor of manic symptoms in a linear regression model with age, gender, BMI and smoking habits as confounding variables.

Conclusions

Our findings suggest that sICAM-1 could be a relevant immune factor for severity of state affective symptoms and could contribute to better understanding of complexity of affective disorders.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-poster walk: Bipolar disorders – Part 2
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S208
Copyright
Copyright © European Psychiatric Association 2017
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