Comparison of treatment response of typical and atypical antipsychotics in acute mania

Abstract

Introduction

The medical treatment of acute mania today mainly includes atypical and typical antipsychotics, lithium or valproat. Atypical antipsychotics are often used as first-line treatment, while typical antipsychotics come with the risk of severe long-term side effects and less used today. However, typical antipsychotics may lead to a faster reduction in the severity of mania or a faster remission of symptoms.

Objective

To investigate whether the acute effect of typical antipsychotics differs from atypical antipsychotics measured by a daily mania rating-scale (MAS-M) and duration of treatment in a real-life clinical setting.

Aim

To help determine if short-term treatment with typical antipsychotics may still be of benefit in the acute treatment of mania.

Methods

This is a retrospective case record study. Patients admitted to an acute hospital ward with acute mania between 2012 and 2015 were included (n = 100). The daily use of atypical and typical antipsychotics will be compared by daily change in Bech-Rafaelsen Modified Mania Scale (Mas-M) score and time to discharge. The change in mania over time is presented visually using graph curves.

Results

The data extraction and data handling will be executed in the winter 2015–2016.

Conclusions

Any preliminary findings will be presented at EPA 2016.