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Comparing the distribution of neuropsychiatric symptoms among individuals with depression and mild cognitive impairment

Published online by Cambridge University Press:  19 July 2023

A. Keng ,
D. Kapustin ,
C. Ma ,
K. Bingham ,
C. Fischer ,
L. Mah ,
D. Gallagher ,
M. A. Butters ,
C. R. Bowie  and
A. Voineskos
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A. Keng*
Affiliation:
1Psychiatry, University of Toronto 2Psychiatry, Baycrest Hospital
D. Kapustin
Affiliation:
1Psychiatry, University of Toronto
C. Ma
Affiliation:
3Centre for Addictions and Mental Health 4Dalla Lana School of Public Health, University of Toronto
K. Bingham
Affiliation:
1Psychiatry, University of Toronto 5Psychiatry, University Health Network
C. Fischer
Affiliation:
1Psychiatry, University of Toronto 6Psychiatry, Unity Health, Toronto
L. Mah
Affiliation:
1Psychiatry, University of Toronto 7Psychiatry, Baycrest Hospital
D. Gallagher
Affiliation:
1Psychiatry, University of Toronto 8Psychiatry, Sunnybrook Hospital, North York
M. A. Butters
Affiliation:
9Psychiatry, University of Pittsburgh, Pittsburgh
C. R. Bowie
Affiliation:
10Psychiatry, Queens University, Kingston
A. Voineskos
Affiliation:
1Psychiatry, University of Toronto 11Psychiatry, Centre for Addictions and Mental Health, Toronto, Canada
A. Graff
Affiliation:
1Psychiatry, University of Toronto 11Psychiatry, Centre for Addictions and Mental Health, Toronto, Canada
A. Flint
Affiliation:
1Psychiatry, University of Toronto 5Psychiatry, University Health Network
N. Herrmann
Affiliation:
1Psychiatry, University of Toronto 8Psychiatry, Sunnybrook Hospital, North York
B. Pollock
Affiliation:
1Psychiatry, University of Toronto 11Psychiatry, Centre for Addictions and Mental Health, Toronto, Canada
B. Mulsant
Affiliation:
1Psychiatry, University of Toronto 11Psychiatry, Centre for Addictions and Mental Health, Toronto, Canada
T. Rajji
Affiliation:
1Psychiatry, University of Toronto 11Psychiatry, Centre for Addictions and Mental Health, Toronto, Canada
S. Kumar
Affiliation:
1Psychiatry, University of Toronto 11Psychiatry, Centre for Addictions and Mental Health, Toronto, Canada
P.-M. Study Group
Affiliation:
11Psychiatry, Centre for Addictions and Mental Health, Toronto, Canada
*
*Corresponding author.

Abstract

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Introduction

Neuropsychiatric symptoms (NPS) are common during the course of neurocognitive disorders. NPS have been previously reported in early and late stages of Alzheimer’s Disease. However, our understanding of NPS in high-risk states for dementia such as mild cognitive impairment (MCI) and major depressive disorder (MDD) is poor.

Objectives

To compare the frequency and factor structure of neuropsychiatric symptoms among individuals with Mild Cognitive Impairment (MCI), Major Depressive Disorder (MDD) in remission, and comorbid MCI and MDD (in remission) (MCI-D).

Methods

We used baseline data from the Prevention of Alzheimer’s Dementia with Cognitive Remediation Plus Transcranial Direct Current Stimulation in Mild Cognitive Impairment and Depression (PACt-MD) study, a multicenter trial across five academic sites in Toronto, Canada (clinical trial No. NCT0238667). We used ANOVA or χ2-test to compare frequency of NPS across groups. We used factor analysis of Neuropsychiatric Inventory Questionnaire (NPI-Q) items in the three groups.

Results

We included 374 participants with a mean age of 72.0 years (SD = 6.3). In the overall sample, at least one NPS was present in 64.2% participants, and 36.1 % had at least moderate severity NPS (36.1%). Depression (54%, χ2 < 0.001) and apathy (28.7%, χ2=0.002) were more prevalent in the MCI-D group as compared to MCI and MDD groups. In factor analysis, NPS grouped differently in MCI, MDD, and MCI-D groups. A “psychotic” subgroup emerged among MCI and MCI-D, but not in MDD. Night-time behaviors and disinhibition grouped differently across all three groups.

Conclusions

Prevalence of NPS seems higher in persons with MCI-D as compared to those with only MCI or MDD. The factor structure of NPS differed between MCI, MDD, and MCI-D groups. Future studies should investigate the association of NPS factors with cognition, function, and illness biomarkers.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S173
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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