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The Common Side Effects of Long Term Treatment with Clozapine and Their Impact: a Sri Lankan Experience

Published online by Cambridge University Press:  15 April 2020

S.W. Kotalawala ,
K.P.M. Dalpatadu ,
C.U. Suraweera ,
K.G.C.L. Kapugama ,
H.G.V.W. Wijesiri ,
V. De Silva  and
R. Hanwella
S.W. Kotalawala
Affiliation:
University Psychiatry Unit, Lady Ridgeway Hospital for Children, Colombo, Sri Lanka
K.P.M. Dalpatadu
Affiliation:
University Psychiatry Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka
C.U. Suraweera
Affiliation:
University Psychiatry Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka
K.G.C.L. Kapugama
Affiliation:
University Psychiatry Unit, Colombo North Teaching Hospital Ragama, Ragama, Sri Lanka
H.G.V.W. Wijesiri
Affiliation:
University Psychiatry Unit, Colombo South Teaching Hospital Kalubovila, Colombo, Sri Lanka
V. De Silva
Affiliation:
University Psychiatry Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka
R. Hanwella
Affiliation:
University Psychiatry Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka

Abstract

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Objectives

To analyse the side effects experienced by patients who are on clozapine for a period of more than one year and to analyse the impact of the side effects.

Methods

A descriptive cross sectional study carried out in University Psychiatry unit, National Hospital of Sri Lanka, Colombo. All patients attending the clozapine clinic within one month and who are on clozapine for a period of more than one year and who are in remission were selected. Interviewer administered questionnaire was used to assess the presence of side effects and their impact. Data was analyzed using SPSS software.

Results

Sample was 63. Mean age was 34.9 years (range 18-60). Mean duration of usage of clozapine is 7.0 years (range 1-20). Fifty seven (71.4%) had hyper-salivation and constipation and 12 (19.0%) had nocturnal enuresis. Majority of patients who had hyper-salivation (86.6%) and nocturnal enuresis (100%) were not receiving any medical intervention. Fifteen (23.8%) reported the side effects have caused distress for them and 19% (n=12) revealed they have affected their activities of daily living.

Conclusions

Most common long term side effects were hyper-salivation and constipation. Majority of patients with hyper-salivation were not receiving medical intervention. Majority of patients did not report that the side effects affect their activities of daily living or they cause personal distress.

Type
Article: 1586
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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