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Combined Effect of TLR2 Gene Polymorphism and Early Life Stress On the Age at Onset of Bipolar Disorders

Published online by Cambridge University Press:  15 April 2020

J. Oliveira ,
B. Etain ,
M. Lajnef ,
N. Hamdani ,
M. Bennabi ,
F. Bellivier ,
J.P. Kahn ,
D. Charron ,
R. Krishnamoorthy  and
M. Leboyer
...Show all authors
J. Oliveira
Affiliation:
Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France
B. Etain
Affiliation:
Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France
M. Lajnef
Affiliation:
Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France
N. Hamdani
Affiliation:
Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France
M. Bennabi
Affiliation:
Institut Universitaire d'Hématologie, INSERM U1160, Paris, France
F. Bellivier
Affiliation:
Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France
J.P. Kahn
Affiliation:
Centre Hospitalier Universitaire de Nancy, Service de Psychiatrie et Psychologie Clinique, Vandoeuvre Les Nancy, France
D. Charron
Affiliation:
Institut Universitaire d'Hématologie, INSERM U1160, Paris, France
R. Krishnamoorthy
Affiliation:
Institut Universitaire d'Hématologie, INSERM U1160, Paris, France
M. Leboyer
Affiliation:
Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France
R. Tamouza
Affiliation:
Institut Universitaire d'Hématologie, INSERM U1160, Paris, France

Abstract

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Immune dysfunction is thought to be animportant pathway underlying the association of childhood traumatic events withearly-onset of bipolar disorder (BD). The study of gene-environmentinteractions are important to better understand the genetics of resilience orsusceptibility to this severe subform of BD. We thus explored the potentialinteraction of genetic variants of TLR2 and TLR4, major triggers of inflammatoryresponses in presence of pathogens, and the presence of childhood trauma on theage at onset of BD.

TLR2 and TLR4 risk genotype carrier state and history of childhood emotional, physical and sexual abuses were analyzed in relation to age at onset of BD in531 BD patients genotyped for TLR2 rs4696480and rs3804099 and TLR4 rs1927914 and rs11536891, 329 of which completed the Childhood TraumaQuestionnaire.

We report a combined effect of TLR2 rs3804099TT genotype and reported sexual abuse on determining an earlier age at onset of BD by means of a Kaplan-Meier survival curve (p= 0.02). Regression analysis was non-significant for the TLR2-CTQ sexual abuse interaction term.

The pathological effect of childhood adversity may be of greater importance in patients with an immuno-genetic susceptibility background. Further exploration of clinical characteristics of severity and immune phenotypes in BD may allow the development of innovative therapeutic interventions.

Type
Article: 0445
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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