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Cognitive impairment associated with drug use in old age people

Published online by Cambridge University Press:  23 March 2020

E. Ros-Cucurull ,
C. Cardona-Rubira ,
E. García-Raboso ,
R.F. Palma-Álvarez ,
L. Grau-López ,
C. Daigre ,
L. Rodríguez-Cintas ,
M. Sorribes-Puertas ,
R. Martínez-Arias  and
A. Cuautle
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E. Ros-Cucurull
Affiliation:
Vall Hebron University Hospital, Addiction and Dual Diagnosis Unit, Barcelona, Spain Autonomous University of Barcelona, Psychiatry Department, Barcelona, Spain Vall Hebron University Hospital CIBERSAM, Psychiatry Service, Barcelona, Spain
C. Cardona-Rubira
Affiliation:
Vall Hebron University Hospital CIBERSAM, Psychiatry Service, Barcelona, Spain Vall Hebron University Hospital CIBERSAM, Neuropsychology Service, Barcelona, Spain
E. García-Raboso
Affiliation:
Vall Hebron University Hospital CIBERSAM, Psychiatry Service, Barcelona, Spain Vall Hebron University Hospital CIBERSAM, Neuropsychology Service, Barcelona, Spain
R.F. Palma-Álvarez
Affiliation:
Vall Hebron University Hospital, Addiction and Dual Diagnosis Unit, Barcelona, Spain Vall Hebron University Hospital CIBERSAM, Psychiatry Service, Barcelona, Spain
L. Grau-López
Affiliation:
Vall Hebron University Hospital, Addiction and Dual Diagnosis Unit, Barcelona, Spain Autonomous University of Barcelona, Psychiatry Department, Barcelona, Spain Vall Hebron University Hospital CIBERSAM, Psychiatry Service, Barcelona, Spain
C. Daigre
Affiliation:
Vall Hebron University Hospital, Addiction and Dual Diagnosis Unit, Barcelona, Spain Autonomous University of Barcelona, Psychiatry Department, Barcelona, Spain Vall Hebron University Hospital CIBERSAM, Psychiatry Service, Barcelona, Spain
L. Rodríguez-Cintas
Affiliation:
Vall Hebron University Hospital, Addiction and Dual Diagnosis Unit, Barcelona, Spain Autonomous University of Barcelona, Psychiatry Department, Barcelona, Spain Vall Hebron University Hospital CIBERSAM, Psychiatry Service, Barcelona, Spain
M. Sorribes-Puertas
Affiliation:
Vall Hebron University Hospital, Addiction and Dual Diagnosis Unit, Barcelona, Spain Vall Hebron University Hospital CIBERSAM, Psychiatry Service, Barcelona, Spain
R. Martínez-Arias
Affiliation:
Adult Psychiatry Outpatient Unit IAS, Psychiatry Service, Gerona, Spain
A. Cuautle
Affiliation:
Hospital de la Merced, Department of Old Age Psychiatry, Barcelona, Spain
M.B. Ortiz-Medina
Affiliation:
Hospital de la Merced, Department of Old Age Psychiatry, Barcelona, Spain
C. Fadeuilhe
Affiliation:
Vall Hebron University Hospital CIBERSAM, Psychiatry Service, Barcelona, Spain
C. Jacas
Affiliation:
Vall Hebron University Hospital CIBERSAM, Psychiatry Service, Barcelona, Spain Vall Hebron University Hospital CIBERSAM, Neuropsychology Service, Barcelona, Spain
M. Casas
Affiliation:
Autonomous University of Barcelona, Psychiatry Department, Barcelona, Spain Vall Hebron University Hospital CIBERSAM, Psychiatry Service, Barcelona, Spain
C. Roncero
Affiliation:
Vall Hebron University Hospital, Addiction and Dual Diagnosis Unit, Barcelona, Spain Autonomous University of Barcelona, Psychiatry Department, Barcelona, Spain Vall Hebron University Hospital CIBERSAM, Psychiatry Service, Barcelona, Spain

Abstract

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Introduction

Substance use disorder is a growing phenomenon among old adults. It is usually significantly undervalued, misidentified, under diagnosed and poorly treated. It has been related to cognitive impairment but there are few studies focused on the elderly.

Aim

To evaluate the relationship between drug use and cognitive impairment in old adults.

Methods

We conducted a prospective study (basal and 6 month follow up) in 67 patients over 65 years old seeking for treatment for drug misuse (alcohol and prescription drugs, mainly benzodiacepines) in addiction and dual diagnosis unit in Barcelona. A specific protocol was performed to evaluate attention, executive function, working memory, learning capacity, fonetic and visual fluency, decision-making, visual construction and cognitive flexibility (FCT, CPT-II, N-BACK, COWAT FAS, TAP, SDMT, IGT, CVLT, TOL, RFFT, STROOP). Patients were compared with a control group (healthy non drug users) with same characteristics (gender, age range and education status). The protocol consisted in two separated sessions of 90 minutes each one performed by a neuropsychologist.

Results

Results obtained suggested that patients under drug misuse had worse scores in fluency, visual construction, memory and attention compared with controls. After 6 month treatment and achieving abstinence patients improve in cognitive skills as verbal learning, short-term memory and free recall of verbal information. Cognitive impairment profile changes depending on the substance abused (alcohol or benzodiacepines).

Conclusions

Drug use can produce deleterious effects in old adults. However, those who achieve abstinence may improve some cognitive functioning as verbal learning, short-term memory and free recall of verbal information.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster viewing: Substance related and addictive disorders
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. s876
Copyright
Copyright © European Psychiatric Association 2017
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