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Clinical high-risk criteria of psychosis in 8- to 17-year-old community subjects and inpatients not suspected to develop psychosis: not pluripotential or transdiagnostic

Published online by Cambridge University Press:  01 September 2022

F. Schultze-Lutter ,
C. Michel ,
M. Franscini ,
N. Traber-Walker ,
P. Walger  and
B. Schimmelmann
F. Schultze-Lutter*
Affiliation:
Heinrich-Heine University Düsseldorf, Department Of Psychiatry And Psychotherapy, Düsseldorf, Germany
C. Michel
Affiliation:
University of Bern, University Hospital Of Child And Adolescent Psychiatry And Psychotherapy, Bern, Switzerland
M. Franscini
Affiliation:
University of Zürich, Department Of Child And Adolescent Psychiatry And Psychotherapy, Zürich, Switzerland
N. Traber-Walker
Affiliation:
University of Zürich, Department Of Child And Adolescent Psychiatry And Psychotherapy, Zürich, Switzerland
P. Walger
Affiliation:
Heinrich-Heine University Düsseldorf, Department Of Psychiatry And Psychotherapy, Düsseldorf, Germany
B. Schimmelmann
Affiliation:
University of Bern, University Hospital Of Child And Adolescent Psychiatry And Psychotherapy, Bern, Switzerland
*
*Corresponding author.

Abstract

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Introduction

Based on high rates of non-converters to psychosis, especially in children and adolescents, it was suggested that CHR criteria were (1) pluripotential, (2) a transdiagnostic risk factor, or (3) simply a severity marker of mental disorders rather than specifically psychosis-predictive. If any of these three alternative explanatory models were true, their prevalence should differ between persons with and without mental disorders, and their severity should be associated with functional impairment as a measure of severity.

Objectives

To compare the prevalence and severity of CHR criteria/symptoms in children and adolescents of the community and inpatients.

Methods

We compared CHR criteria/symptoms in 8-17-year-olds of the community and of inpatients not clinically suspected to develop psychosis.

Results

The 7.3%-prevalence rate of CHR criteria in community subjects did not differ significantly from the 9.5%-rate in inpatients. Frequency/severity of CHR criteria never differed between the community and the four inpatient groups, while the frequency and severity of CHR symptoms differed only minimally. Group differences were found in only four CHR symptoms: suspiciousness/persecutory ideas of the SIPS, and thought pressure, derealization and visual perception disturbances of the SPI-CY. These were consistent with a transdiagnostic risk factor or dimension, i.e., displayed higher frequency and severity in inpatients. Low functioning, however, was at most weakly related to the severity of CHR criteria/symptoms, with the highest, yet still weak correlation yielded for suspiciousness/persecutory ideas.

Conclusions

The lack of systematic differences between inpatients and community subjects does not support suggestions that CHR criteria/symptoms are pluripotential or transdiagnostic syndromes, or merely markers of symptom severity

Disclosure

No significant relationships.

Keywords

pluripotent risk factortransdiagnostic risk indicatorchildren and adolescentsclinical high risk
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S681
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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