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Circadian clock gene Per3 variants influence the postpartum onset of bipolar disorder

Published online by Cambridge University Press:  16 April 2020

S. Dallaspezia ,
C. Lorenzi ,
A. Pirovano ,
C. Colombo ,
E. Smeraldi  and
F. Benedetti
S. Dallaspezia*
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
C. Lorenzi
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
A. Pirovano
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
C. Colombo
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
E. Smeraldi
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
F. Benedetti
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
*
*Corresponding author. Istituto Scientifico Ospedale San Raffaele, Department of Clinical Neurosciences, San Raffaele Turro, Via Stamira d'Ancona 20, Milano, Italy. Tel.: +39 02 26433156; fax: +39 02 26433265. E-mail address: [email protected] (S. Dallaspezia).
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Abstract

Postpartum depression can mark the onset of bipolar disorder. The coding region of Per3 gene contains a variable-number tandem-repeat polymorphism, which has been shown to influence bipolar disorder onset and to affect breast cancer risk. We showed a relationship between Per3 polymorphism and postpartum depressive onset in bipolar disorder.

Keywords

Postpartum depressionBipolar disorderClock genesPer3 gene VNTR polymorphism
Type
Short communication
Information
European Psychiatry , Volume 26 , Issue 3 , April 2011 , pp. 138 - 140
Copyright
Copyright © Elsevier Masson SAS 2011

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