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Characteristic brain hypoperfusion by 99mTc-ECD single photon emission computed tomography (SPECT) in patients with the first-episode schizophrenia

Published online by Cambridge University Press:  16 April 2020

R. Wake ,
T. Miyaoka ,
K. Kawakami ,
K. Tsuchie ,
T. Inagaki ,
J. Horiguchi ,
Y. Yamamoto ,
T. Hayashi  and
H. Kitagaki
R. Wake*
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1, Enyacho, Izumo693-8501, Japan
T. Miyaoka
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1, Enyacho, Izumo693-8501, Japan
K. Kawakami
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1, Enyacho, Izumo693-8501, Japan
K. Tsuchie
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1, Enyacho, Izumo693-8501, Japan
T. Inagaki
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1, Enyacho, Izumo693-8501, Japan
J. Horiguchi
Affiliation:
Department of Psychiatry, Shimane University School of Medicine, 89-1, Enyacho, Izumo693-8501, Japan
Y. Yamamoto
Affiliation:
Department of Radiology, Shimane University School of Medicine Hospital, 89-1, Enyacho, Izumo693-8501, Japan
T. Hayashi
Affiliation:
Department of Radiology, Shimane University School of Medicine Hospital, 89-1, Enyacho, Izumo693-8501, Japan
H. Kitagaki
Affiliation:
Department of Radiology, Shimane University School of Medicine Hospital, 89-1, Enyacho, Izumo693-8501, Japan
*
*Corresponding author. Tel.: +81 853 20 2263; fax: +81 853 20 2260. E-mail address: [email protected] (R. Wake).
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Abstract

Objective

In this study, we evaluated brain perfusion in patients with first-episode medicated schizophrenia using the new analytical method, statistical parametric mapping (SPM) applied to single photon emission computed tomography (SPECT).

Method

We performed SPECT with 99-Tc-ethyl cysteinate dimer (99mTc-ECD) of the brain and magnetic resonance imaging (MRI) in patients with schizophrenia (n = 30) and control subjects matched for age and gender (n = 37). A voxel-by-voxel group analysis was performed using SPM2 (Z > 3.0, P < 0.001, uncorrected for multiple comparisons).

Result

In comparison with control subjects, the volumes of the bilateral frontal areas were found to be decreased on MRI. Blood flow was found to be reduced in the bilateral temporal areas in the patients with schizophrenia on SPECT.

Conclusion

In this study, patients with first-episode schizophrenia appeared to have significant bilateral temporal hypoperfusion, although temporal volumes were not significantly decreased in comparison with control subjects. Abnormality of temporal lobe blood flow in schizophrenia may show that functional changes occur earlier than structural changes, and may assist in the diagnosis of schizophrenia.

Keywords

SchizophreniaNeuroimagingSPECT
Type
Brain Anatomy and Imaging
Information
European Psychiatry , Volume 25 , Issue 6 , October 2010 , pp. 361 - 365
Copyright
Copyright © Elsevier Masson SAS 2010

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References

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Press; 1994. 273–315.Google Scholar
Andreasen, NCNeural mechanisms of negative symptoms. Br J Psychiatry 1989;155(Suppl. 7):93–98.CrossRefGoogle Scholar
Andreasen, NC, Razai, K, Alliger, R, Swayze, VW, Flaum, M, Kirchner, Pet al.Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia. Assessment with xenon 133 single photon emission computed tomography and the Tower of London. Arch Gen Psychiatry 1992;49:943–958.CrossRefGoogle ScholarPubMed
Andreasen, NC, Flashman, L, Flaum, M, Arndt, S, Swayze, V2 O’Leary, DSet al.Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. JAMA 1994;272:1763–1769.CrossRefGoogle ScholarPubMed
Benes, FM, McSparren, J, Bird, ED, San Giovanni, JP, Vicent, SLDeficits in small interneurons in prefrontal and cingulated cortices of schizophrenic and schizoaffective patients. Arch Gen Psychiatry 1991;48:996–1001.CrossRefGoogle Scholar
Catafau, AM, Parellada, E, Lomena, FJ, Bernardo, M, Pavia, J, Ros, Det al.Prefrontal and temporal blood flow in schizophrenia: resting and activation technetium-99m-HMPAO SPECT patterns in young neuroleptic-naive patients with acute disease. J Nucl Med 1994;35:935–941.Google ScholarPubMed
Ebert, D, Feistel, H, Kaschka, WLeft temporal hypoperfusion in catatonic syndromes: a SPECT study. Psychiatry Res Neuroimaging 1992;45:239–241.CrossRefGoogle ScholarPubMed
Flor-Henry, PLateralized temporal-limbic dysfunction and psychopathology. Ann N Y Acad Sci 1976;280:777–797.CrossRefGoogle ScholarPubMed
Gonul, AS, Kula, M, Esel, E, Tutus, A, Sofuoglu, SA Tc-99m HMPAO SPECT study of regional cerebral blood flow in drug-free schizophrenic patients with deficit and non-deficit syndrome. Psychiatry Res Neuroimaging 2003;123:199–205.CrossRefGoogle ScholarPubMed
Guedj, E, Taieb, D, Cammilleri, S, Lussato, D, Laforte, C, Nioyet, Jet al.99mTc-ECD brain perfusion SPECT in hyperalgestic fibromyalgia. Eur J Nucl Med Mol Imaging 2007;34:130–134.CrossRefGoogle ScholarPubMed
Heckers, S, Goff, D, Schacter, DL, Savage, CR, Fischman, AJ, Alpert, NMet al.Functional imaging memory retrieval in deficit vs. nondeficit schizophrenia. Arch Gen Psychiatry 1999;56:1117–1123.CrossRefGoogle ScholarPubMed
Honey, GD, Sharma, T, Suckling, J, Giampietro, V, Soni, W, Williams, SCet al.The functional neuroanatomy of schizophrenic subsyndromes. Psychol Med 2003;33:1007–1018.CrossRefGoogle ScholarPubMed
Hyun, Y, Lee, JS, Rha, JH, Lee, IK, Ha, CK, Lee, DSDifferent uptake of 99mTc ECD and 99mTc-HMPAO in the same brains: analysis by statistical parametric mapping. Eur J Nucl Med 2001;28:191–197.CrossRefGoogle ScholarPubMed
Ingvar, DH, Franzen, GAbnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr Scand 1974;50:425–462.CrossRefGoogle ScholarPubMed
Ingvar, DH, Franzen, GDistribution of cerebral activity in chronic schizophrenia. Lancet 1974;2:1484–1486.CrossRefGoogle ScholarPubMed
Kay, SR, Fiszbein, A, Opler, LAThe positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13:261–276.CrossRefGoogle Scholar
Kohno, T, Shiga, T, Kageyama, H, Kaji, T, Katoh, C, Tamaki, NLeft temporal perfusion is positively correlated with suspiciousness score in schizophrenia. Psychiatry Res Neuroimaging 2006;147:163–171.CrossRefGoogle Scholar
Kraepelin, EDementia Praecox and Paraphrenia. Huntington, NY: R.E. Krieger Publishing Co.; 1971.Google Scholar
Miller, DD, Andreasen, NC, O’Leary, DS, Watkins, GL, Ponto, LLB, Hichwa, RDComparison of the effects of risperidone and haloperidol on regional cerebral blood flow in schizophrenia. Biol Psychiatry 2001;49:704–715.CrossRefGoogle Scholar
Min, SK, An, SK, Jon, DI, Lee, JDPositive and negative symptoms and regional cerebral perfusion in antipsychotic-naive schizophrenic patients: a high-resolution SPECT study. Psychiatry Res Neuroimaging 1999;90:159–168.CrossRefGoogle ScholarPubMed
Minoshima, S, Koeppe, RA, Frey, KA, Kuhl, DEAnatomical standardization: Linear scaling and non linear warping pgi functional brain images. J Nucl Med 1994;35:1528–1537.Google Scholar
Minoshima, S, Frey, KA, Koeppe, RA, Foster, NL, Kuhl, DEA diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorin-18-FDG PET. J Nucl Med 1995;36:1238–1248.Google ScholarPubMed
Minoshima, S, Giordni, B, Berent, S, Foster, NL, Kuhl, DEMetabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol 1997;42:85–94.CrossRefGoogle ScholarPubMed
Mizumura, S, Kumita, SStereotactic statistical imaging analysis of the brain using the easy Z-score imaging system for sharing a normal database. Radiat Med 2006;24:545–552.CrossRefGoogle ScholarPubMed
Molina, V, Gispert, JD, Reig, S, Pascau, J, Martinez, R, Sanz, Jet al.Olanzapine-induced cerebral metabolic changes related to symptom improvement in schizophrenia. Int Clin Psychopharmacol 2005;20:13–18.CrossRefGoogle Scholar
Molina, V, Gispert, JD, Reig, S, Sanz, J, Pascau, J, Santos, Aet al.Cerebral metabolic changes induced by clozapine in schizophrenia and related to clinical improvement. Psychopharmacology 2005;178:17–26.CrossRefGoogle ScholarPubMed
Musalek, M, Podreka, I, Walter, HRegional brain function in hallucinations: a study of regional cerebral blood flow with 99mTc-HMPAO-SPECT in patients with auditory hallucinations, tactile hallucinations and normal controls. Compr Psychiatry 1989;30:99–108.CrossRefGoogle Scholar
Nester, PG, Shenton, ME, McCarly, RWNeuropsychological correlates of MRI temporal lobe abnormalities in schizophrenia. Am J Psychiatry 1993;150:1849–1855.Google Scholar
Oldfield, RCThe assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971;9:97–113.CrossRefGoogle ScholarPubMed
Overall, JE, Gorham, DEThe brief psychiatric rating scale. Psychol Rep 1962;10:799–812.CrossRefGoogle Scholar
Parellada, E, Catafau, AM, Bernardo, M, Lomena, F, Catarineu, S, Gonzalez-Monclus, EThe resting and activation issue of hypofrontality: a single photon emission computed tomography study in neuroleptic-naive and neuroleptic-free schizophrenic female patients. Biol Psychiatry 1998;44:787–790.CrossRefGoogle ScholarPubMed
Puri, BK, Lekh, SK, Nijran, KS, Bagary, MS, Richardson, AJSPECT neuroimaging in schizophrenia with religious delusions. Int J Psychophysiol 2001;40:143–148.CrossRefGoogle ScholarPubMed
Rajkowska, G, Selemon, LD, Goldman- Rakic, PSNeuronal and glial somal size in prefrontal cortex. A post mortem morphometric study of schizophrenia and Huntington disease. Arch Gen Psychiatry 1998;55:215–224.CrossRefGoogle Scholar
Shenton, ME, Dickey, CC, Frumin, M, Mc Carley, RWA review of MRI findings in schizophrenia. Schizophr Res 2001;49:1–52.CrossRefGoogle Scholar
Suzuki, M, Nohara, S, Hagino, H, Kurokawa, K, Yotsutsuji, T, Kawasaki, Yet al.Regional changes in brain gray and white matter in patients with schizophrenia demonstrated with voxel-based analysis of MRI. Schizophr Res 2002;55:41–54.CrossRefGoogle ScholarPubMed
Tamminga, CA, Thaker, OK, Buchanan, R, Kirkpatrick, B, Alphs, LD, Chase, TNet al.Limbic system abnormalities identified in schizophrenis using positron emission tomography with fluorodeoxyglucose and neocortical alteration with deficit syndrome. Arch Gen Psychiatry 1992;49:522–530.CrossRefGoogle Scholar
Vita, A, Bressi, S, Perani, DHigh-resolution SPECT study of regional cerebral blood flow in drug-free and drug-naive schizophrenic patients. Am J Psychiatry 1995;152:876–882.Google ScholarPubMed
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