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Changes in sleep with transcranial magnetic stimulation in adults with treatment resistant depression: Preliminary results from a naturalistic study

Published online by Cambridge University Press:  13 August 2021

A.I. Sonmez ,
R. Kay ,
S. Schmids ,
C. Peterson ,
A. Herman ,
A. Widge ,
Z. Nahas  and
C.S. Albott
A.I. Sonmez*
Affiliation:
Psychiatry And Behavioral Sciences, University of Minnesota, Minneapolis, United States of America
R. Kay
Affiliation:
Psychiatry And Behavioral Sciences, University of Minnesota, Minneapolis, United States of America
S. Schmids
Affiliation:
Psychiatry And Behavioral Sciences, University of Minnesota, Minneapolis, United States of America
C. Peterson
Affiliation:
Psychiatry And Behavioral Sciences, University of Minnesota, Minneapolis, United States of America
A. Herman
Affiliation:
Psychiatry And Behavioral Sciences, University of Minnesota, Minneapolis, United States of America
A. Widge
Affiliation:
Psychiatry And Behavioral Sciences, University of Minnesota, Minneapolis, United States of America
Z. Nahas
Affiliation:
Psychiatry And Behavioral Sciences, University of Minnesota, Minneapolis, United States of America
C.S. Albott
Affiliation:
Psychiatry And Behavioral Sciences, University of Minnesota, Minneapolis, United States of America
*
*Corresponding author.

Abstract

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Introduction

Sleep disturbance specifically insomnia, non-restorative sleep, and hypersomnia are common symptoms of major depressive disorder (MDD). As it alleviates major depressive disorder, transcranial magnetic stimulation (TMS) may improve associated sleep disturbances, and may also have inherent sedating or activating properties.

Objectives

To examine the impact of TMS on sleep disturbances in adults with treatment resistant depression in a clinical setting, we retrospectively reviewed de-identified data from naturalistically-treated MDD patients undergoing an initial acute course of TMS therapy at St.Louis Park MinCEP Clinic.

Methods

Adults with treatment-resistant depression received daily TMS treatments. 9-item Patient Health Questionnaire (PHQ-9) total scores were used to calculate % change at endpoint (relative to pretreatment baseline); response on both measures was defined as 50% reduction in scores, with remission defined as a final total score 4 on the PHQ-9. Insomnia was measured with a 3-item subscale of the Inventory of Depressive Symptomatology Self Report (IDS-SR). Hypersomnia was measured with a single IDS-SR item. Pairwise comparisons were performed using Student’s T-test. Categorical variables were compared using Fisher’s Exact test. Continuous outcome measures were tested with an analysis of covariance, using baseline PHQ-9 score as a fixed effect covariate.

Results

TMS appears to have differential modulatory effects on insomnia and hypersomnia in adults with treatment resistant depression.

Conclusions

These results may provide the basis for further investigation into therapeutic applications of TMS in addressing sleep disturbances in treatment-resistant depression. Measures that separate hypersomnia and insomnia should be implemented in future work addressing effects of TMS in treatment-resistant depression.

Disclosure

No significant relationships.

Keywords

repetitive transcranial magnetic stimulationtreatment-resistant depressionhypersomniaInsomnia
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S153
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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